Preparation, characterization and investigation of antibacterial silver-zinc co-doped β-tricalcium phosphate by spray pyrolysis

Chou, Yu-Jen; Ningsih, Henni Setia; Shih, Shao‐Ju

doi:10.1016/j.ceramint.2020.03.245

Cited by 32 publications

(16 citation statements)

References 30 publications

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“…The bacterial activity was evaluated based on the plate count technique (ASTM International E3031-15) with quantitative bacteria colonies on a Petri dish, similar to the previous report. 20 The initial bacteria were inoculated overnight in Luria-Bertani medium at 37 C. The concentration of bacteria was diluted in phosphatebuffered saline solution and 1 mg of pristine and metal ions doped HAp samples were added to 0.5 mL diluted bacteria solution (10 3 colony-forming unit, CFU). Subsequently, the 0.5 mL bacteria solution was spread on agar medium on a Petri dish.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…18 Several metal doping ions had been used in the previous reports to enhance the antibacterial activity of HAp, such as silver (Ag + ), zinc (Zn 2+ ), magnesium (Mg 2+ ), and copper (Cu 2+ ) ions. [19][20][21] Among them, silver is the most widely explored due to its high antibacterial activity. 22 Based on the above considerations, hydroxyapatite synthesis and characterization by utilizing earth-abundant limestone resources are highly critical.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterizations of natural limestone-derived nano-hydroxyapatite (HAp): a comparison study of different metals doped HAps on antibacterial activity

et al. 2021

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Section: Antibacterial Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and characterizations of natural limestone-derived nano-hydroxyapatite (HAp): a comparison study of different metals doped HAps on antibacterial activity

et al. 2021

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“…Silver is one of the most used and studied antimicrobial agents due to its broad spectrum of action and low toxicity at low concentrations [15,16]. Compared to Silver, Zinc is a chemical element that is found naturally in bone tissue and is essential for biological processes such as: enzyme activity, DNA synthesis, mitosis, cell proliferation, etc.…”

Section: Of 15mentioning

confidence: 99%

Fabrication of Silver- and Zinc-Doped Hydroxyapatite Coatings for Enhancing Antimicrobial Effect

2020

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This study develops, for the first time, composite coatings based on silver and zinc doped hydroxyapatite in chitosan matrix (AgZnHApCs). The AgZnHApCs composite coatings were prepared by dip coating method. The hydroxyapatite (HAp), biocompatible material for regenerating and strengthening damaged bones were doped with silver and zinc ions and coated with chitosan in order to produce a uniform and homogenous coating with biocompatibility and antimicrobial properties. The stability of AgZnHApCs suspensions was evaluated by ultrasound measurements. The value of stability parameters of AgZnHApCs suspension is in good agreement with the value of bidistilled water used as reference fluid. Homogeneously dispersed solutions of AgZnHApCs were synthesized to endeavor to optimize the physico-chemical and biological characteristics of the coatings obtained at room temperature. The AgZnHApCs composite suspension and coatings were analyzed using various investigation techniques, such as X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenylte-2H-tetrazolium bromide) assay and antimicrobial studies. The optical spectroscopy, atomic force microscopy (AFM), metallographic examination and X-ray photoelectron spectroscopy (XPS) on AgZnHApCs composite coatings were also conducted. Cell culture and MTT assays demonstrate that AgZnHApCs composite suspension and coatings have no negative effect on the cell viability and proliferation. The cell morphology was not affected in presence of AgZnHApCs composite suspension and coatings. The antimicrobial assays conducted against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 90029 microbial strains revealed that both the AgZnHApCs composite suspension and coatings exhibited great antimicrobial properties.

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“…To avoid such issues, doping ceramics with metallic compounds with inherent antibacterial properties can replace the use of antibiotics. In this regard, metal ions, including copper, silver, iron, titanium, strontium, manganese, and zinc, have been doped successfully into bioceramic and hybrid scaffolds, enhancing their anti-infective properties [164][165][166][167][168][169][170][171][172][173][174].…”

Section: Bone Substitutesmentioning

confidence: 99%

Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

Bădilă

Rădulescu

Niculescu

et al. 2021

Cancers

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In the last decades, the treatment of primary and secondary bone tumors has faced a slow-down in its development, being mainly based on chemotherapy, radiotherapy, and surgical interventions. However, these conventional therapeutic strategies present a series of disadvantages (e.g., multidrug resistance, tumor recurrence, severe side effects, formation of large bone defects), which limit their application and efficacy. In recent years, these procedures were combined with several adjuvant therapies, with different degrees of success. To overcome the drawbacks of current therapies and improve treatment outcomes, other strategies started being investigated, like carrier-mediated drug delivery, bone substitutes for repairing bone defects, and multifunctional scaffolds with bone tissue regeneration and antitumor properties. Thus, this paper aims to present the types of bone tumors and their current treatment approaches, further focusing on the recent advances in new therapeutic alternatives.

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Preparation, characterization and investigation of antibacterial silver-zinc co-doped β-tricalcium phosphate by spray pyrolysis

Cited by 32 publications

References 30 publications

Synthesis and characterizations of natural limestone-derived nano-hydroxyapatite (HAp): a comparison study of different metals doped HAps on antibacterial activity

Synthesis and characterizations of natural limestone-derived nano-hydroxyapatite (HAp): a comparison study of different metals doped HAps on antibacterial activity

Fabrication of Silver- and Zinc-Doped Hydroxyapatite Coatings for Enhancing Antimicrobial Effect

Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

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