Preparation of electrospun silk fibroin nanofibers from solutions containing native silk fibrils

Li, Zhi; Zhang, Feng; Ming, Jinfa; Bie, Shiyu; Li, Junjuan; Zuo, Baoqi

doi:10.1002/app.41236

Cited by 46 publications

(49 citation statements)

References 37 publications

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“…Nanofiber based scaffolds are also highly porous structures with good interconnectivity. There is a variety of polymers used for nanofiber fabrication, including both natural, synthetic, and their blends (Bhattarai et al, ; He et al, ; Huang et al, ; Liu et al, ; Shafiee et al, ; Um et al, , Wright et al, ).…”

Section: Advanced Therapiesmentioning

confidence: 99%

Management of knee osteoarthritis. Current status and future trends

Ondrésik

Maia

Morais

et al. 2016

Biotech & Bioengineering

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Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717-739. © 2016 Wiley Periodicals, Inc.

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Section: Advanced Therapiesmentioning

confidence: 99%

Management of knee osteoarthritis. Current status and future trends

Ondrésik

Maia

Morais

et al. 2016

Biotech & Bioengineering

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“…Another way of producing silk mats and nanofibers is electrospinning. Activated, i.e., previously dissolved silk (typically stored in dry form) is re‐dissolved in FA or HFIP‐containing solutions and supplied to the electrospinning system . By changing starter solution (protein concentration content, helper chemicals, and other blended compounds of interest), different aspects of the finally produced materials are governed …”

Section: Formulated Products From Processed Rsfmentioning

confidence: 99%

On the Routines of Wild-Type Silk Fibroin Processing Toward Silk-Inspired Materials: A Review

Volkov

Ferreira

Cavaco-Paulo

2015

Macromol. Mater. Eng.

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For years, silk fibroin of a domestic silkworm, Bombyx mori, has been recognized as a valuable material and extensively used. In the last decades, new application fields are emerging for this versatile material. Those final, specific applications of silk dictate the way it has been processed in industry and research. This review focuses on the description of various approaches for silk downstream processing in a laboratory scale, that fall within several categories. The detailed description of workflow possibilities from the naturally found material to a finally formulated product is presented. Considerable attention is given to (bio‐) chemical approaches of silk fibroin transformation, particularly, to its enzyme‐driven modifications. The focus of the current literature survey is exclusively on the methods applied in research and not industry.

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“…35,38,39 Natural polymers include collagen, [40][41][42] gelatin, 43,44 chitosan, 45,46 and silk fibroin. 47,48 These fibers resemble the natural ECM, as they are thin continuous fibers with a high surface-to-volume ratio. 28,36 Two-dimensional (2D) nanofiber meshes can be used to guide orientation of CNS neurites, not only to aid direct nerve tissue reconnection but also to permit the study of degeneration of the CNS neuron circuitry and high throughput screening.…”

Section: Two-dimensional Nanofibrous Scaffolds For Guiding Cns Neuritmentioning

confidence: 99%

Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review

Kamudzandu¹,

Roach²,

Fricker³

et al. 2015

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Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limited axonal outgrowth toward target tissue. Strategies for promoting CNS functional regeneration include the use of nanotechnology. Due to their structural similarity, synthetic nanofibers could play an important role in regeneration of CNS neural tissue toward restoration of function following injury. Two-dimensional nanofibrous scaffolds have been used to provide contact guidance for developing brain and spinal cord neurites, particularly from neurons cultured in vitro. Three-dimensional nanofibrous scaffolds have been used, both in vitro and in vivo, for creating cell adhesion permissive milieu, in addition to contact guidance or structural bridges for axons, to control reconnection in brain and spinal cord injury models. It is postulated that nanofibrous scaffolds made from biodegradable and biocompatible materials can become powerful structural bridges for both guiding the outgrowth of neurites and rebuilding glial circuitry over the "lesion gaps" resulting from injury in the CNS.

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Preparation of electrospun silk fibroin nanofibers from solutions containing native silk fibrils

Cited by 46 publications

References 37 publications

Management of knee osteoarthritis. Current status and future trends

Management of knee osteoarthritis. Current status and future trends

On the Routines of Wild-Type Silk Fibroin Processing Toward Silk-Inspired Materials: A Review

Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review

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