Preparation of zinc layered hydroxide-ferulate and coated zinc layered hydroxide-ferulate nanocomposites for controlled release of ferulic acid

Hashim, Norhayati; Sharif, Sharifah Norain Mohd; Muda, Zuhailimuna; Isa, Illyas Md; Ali, Noorshida Mohd; Bakar, Suriani Abu; Sidik, Siti Munirah; Hussein, Mohd Zobir

doi:10.1080/14328917.2018.1444696

Cited by 12 publications

(12 citation statements)

References 47 publications

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“…TGA results also demonstrated a subtle increase in the thermal resistance of the microparticles by raising the amount of CMC. Although Span 80 presents a maximum degradation temperature ( T max ~416°C) slightly higher in comparison to Tween 80 ( T max ~413°C), the microparticles produced with Tween 80 presented a better thermal resistance (higher T onset and T max ) than those obtained with Span 80 36–38 . According to Koocheki et al (2011), the polyether moieties of Tween 80 might have interacted with the ester and carboxylic acid groups present in PLLA macromolecules, resulting in a product with a slightly higher thermal resistance 39 .…”

Section: Resultsmentioning

confidence: 99%

Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Silva

Nogueira

2021

J of Applied Polymer Sci

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Metformin hydrochloride (MetHCl) is a drug extensively used to treat diabetes mellitus Type 2. However, its high hydrophilicity drastically reduces its metabolic absorption. Consequently, high drug concentrations should be taken by patients to achieve the desired therapeutical efficiency, causing several side effects. The present study proposes the development of a MetHCl sustained release biopolymeric system composed of poly(L-lactic acid) (PLLA) and carboxymethyl cellulose (CMC) as a strategy to minimize the problems aforementioned. The PLLA-CMC microparticles were produced by the double emulsion-solvent evaporation technique using two distinct emulsifiers in the first emulsion (Span 80 and Tween 80). The microparticles were characterized by ultraviolet-visible spectrophotometry, scanning electron microscopy with field emission gun, thermogravimetric analyses, and differential scanning calorimetry (DSC). Additionally, in vitro drug release assays were performed. The results demonstrated that the emulsion stability and encapsulation efficiency increased in a dependent fashion way with the CMC concentration. DSC findings showed that the choice of the emulsifier of the first emulsion influences the polymer particle's crystallinity and, consequently, the releasing behavior of the drug. The in vitro studies revealed that the encapsulation of MetHCl in PLLA-CMC microparticles is a promising sustained release system compatible with a zero-order kinetic mechanism.

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Section: Resultsmentioning

confidence: 99%

Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Silva

Nogueira

2021

J of Applied Polymer Sci

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“… 12 , 16 , 67 The other variation of the materials includes divalent layered structures such as zinc layered hydroxides which is the most common example and for this type of material, no trivalent ion is added. 68 , 69 In this study, we report for the first time, the synthesis of magnesium layered hydroxide nanomaterials, MgLH, using the co-precipitation method from magnesium nitrate and magnesium oxide as the starting material. The anti-tuberculosis drug, para-aminosalicylic acid (PAS), was successfully intercalated into the interlayers.…”

Section: Discussionmentioning

confidence: 99%

A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties

Saifullah¹,

Arulselvan²,

Zowalaty³

et al. 2021

IJN

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Introduction:Mycobacterium tuberculosis infections are associated with severe local inflammatory reactions, which may be life-threatening and lead to tuberculosis pathogenesis and associated complications. Inorganic nanolayers have been vastly exploited for biomedical applications (especially in drug delivery) because of their biocompatible and biodegradable nature with the ability to release a drug in a sustained manner. Herein, we report a new nanodelivery system of inorganic nanolayers based on magnesium layered hydroxides (MgLH) and a successfully intercalated anti-tuberculosis drug para-aminosalicylic acid (PAS). Methods: The designed anti-tuberculosis nanodelivery composite, MgLH-PAS, was prepared by a novel co-precipitation method using MgNO 3 as well MgO as starting materials. Results:The designed nano-formulation, PAS-MgLH, showed good antimycobacterial and antimicrobial activities with significant synergistic anti-inflammatory effects on the suppression of lipopolysaccharide (LPS) stimulated inflammatory mediators in RAW 264.7 macrophages. The designed nano-formulation was also found to be biocompatible with human normal lung cells (MRC-5) and 3T3 fibroblast cells. Furthermore, the in vitro release of PAS from PAS-MgLH was found to be sustained in human body simulated phosphate buffer saline (PBS) solutions of pH 7.4 and pH 4.8. Discussion: The results of the present study are highly encouraging for further in vivo studies. This new nanodelivery system, MgLH, can be exploited in the delivery of other drugs and in numerous other biomedical applications as well.

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“…In addition, there are no impurities peaks of MCPA detected, thus firmly support ZMCPA layered structure was well ordered and had very good crystallinity at this optimum concentration. The four harmonic peaks exhibit the successful intercalation of MCPA into interlayer region of ZLH (Hashim et al, 2019).…”

Section: = 100%mentioning

confidence: 97%

“…The intercalation of ZLH with its counter anion were known to follow dissociation-deposition mechanisms that consists of three steps (Hashim et. al., 2019;Megat et al, 2013 This process will continuously occur and will stop once ZnO and Zn(OH)2 was perfectly converted to layered organicinorganic hybrid compound.…”

Section: A X-ray Diffraction Analysismentioning

confidence: 99%

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Synthesis and Characterisation of Zinc Layered Hydroxide Intercalated with 2-Methyl-4- Chlorophenoxyacetic Acid and its Controlled Release Application

Ghazali¹

2021

ASMScJ

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2-methyl-4-chlorophenoxyacetic acid (MCPA) is herbicide in group of phenoxyherbicides. It has been widely used in agriculture industry to control the weeds population especially thistle and dock. The toxicity of MCPA may impact the environment and harmful for living organisms especially human and aquatic life. This research aimed to intercalate MCPA herbicide with zinc layered hydroxide (ZLH) to form a composites (ZMCPA) and its controlled release properties. In this study, ZMCPA was prepared as an advanced delivery system by ion exchange method and further by hydrothermal treatment. The intercalations of zinc oxide were done with various MCPA concentration of 0.1 M, 0.3 M, 0.5 M, 0.7 M and 0.9 M. Intercalation performances were detected using powder X- ray diffraction (PXRD) and supported by Fourier Transform infrared spectroscopy (FTIR). The study for porosity of the composite was performed by BET analyzer. Among all of these concentrations, 0.5M represented the successful intercalation due to the presence of four sharp and intense harmonic peaks at 2θ with basal spacing of 24.6 Å, 12 Å, 8 Å and 6 Å, respectively. Herbicides release study was conducted in three salt solution, sodium chloride, sodium carbonate and sodium phosphate. Sustain release of MCPA was faster in sodium phosphate solution by 85%. This controlled release study was determined by UV-Vis spectrometry.

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Preparation of zinc layered hydroxide-ferulate and coated zinc layered hydroxide-ferulate nanocomposites for controlled release of ferulic acid

Cited by 12 publications

References 47 publications

Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties

Synthesis and Characterisation of Zinc Layered Hydroxide Intercalated with 2-Methyl-4- Chlorophenoxyacetic Acid and its Controlled Release Application

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