Production and Properties of Radioactive Microspheres for Localized Irradiation of Lung Tissue

Ec, Anderson; Jd, Perrings

doi:10.1097/00004032-197803000-00003

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Materi4l a N D Methods1

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1979

1980

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Cited by 4 publications

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“…The starting material in the nebulizer (Mercar et a/., 1968) was zirconium dioxide sol identical to that used in the process of manufacturing microspheres for i.v. injection (Anderson and Perrings, 1978). The desired amount of 2 3 8 or 2 3 Y P~( N~3 ) 4 was added to the sol plus a small amount of "CO gamma-emitting tracer.…”

Section: Materi4l a N D Methodsmentioning

confidence: 99%

Lung tumors from PuO₂‐ZrO₂ aerosol particles in syrian hamsters

Thomas

Smith

1979

Intl Journal of Cancer

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Syrian golden hamsters were given PuO2/ZrO2 particles via inhalation and/or Pu-laden ZrO2 ceramic 10-micron diameter microspheres lodged in the capillary bed of the lung. The mean initial lung burdens ranged from 8 nCi to 143 nCi for the six experimental groups of animals. Significant numbers of primary lung tumors (5-50% per group) were induced in those animals that received inhalation exposures. Additional alpha radiation administered via Pu-laden intravenous microspheres had little or no effect on tumorigenesis or the production of non-neoplastic, degenerative changes in the respiratory tract.

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Section: Materi4l a N D Methodsmentioning

confidence: 99%