Tumorigenic Hazard of Particulate α Activity in Syrian Hamster Lungs

Anderson, E. C.; Holland, L.M.; Prine, J.R.; Smith, David M.

doi:10.2307/3575009

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…If one group of animals with median survival time of 90 days is eliminated from consideration as not surviving long enough to be at risk for tumors, then the entire experiment is within the 80% confidence limit for both models. This exclusion is consistent with the exclusion of all animals dying before 100 days in the experiment involving injected microspheres (Anderson et al 1979). If the dose-rate distribution resulting from the more clumped late distribution of particles is used, the overall tumor probabilities are lowered to improve the agreement with predictions by about 25%.…”

Section: Particle Distribution In Hamsterssupporting

confidence: 59%

“…Syrian hamsters exposed to alpha irradiation from internally deposited randomly distributed stationary microspheres containing Pu (Anderson et al 1974;Anderson et al 1979) furnished an ideal model to obtain a dose-effect relationship for randomly distributed particles in lung. Since the microspheres did not move around in the lung, the dose distribution remained constant throughout the lifetime of the animals.…”

Section: Discussionmentioning

confidence: 99%

“…Dose-effect data for Syrian hamsters injected with Pu-labeled microspheres in the jugular vein (Anderson et al 1979) were used to determine the constants appropriate for these two expressions. The microspheres injected in this way lodged in the microvasculature of the lung resulting in a static random distribution of the microspheres, which for any given injection group were all of the same activity per microsphere (Anderson et al 1974).…”

Section: Particle Distribution In Hamstersmentioning

confidence: 99%

“…The dose and tissue-at-risk distributions measured were used with existing dose-effect models to compare the results of several studies in which Syrian hamsters had long-term burdens of Pu particles in lung. The best model of lung tumor induction obtained from an "ideal" experiment (Anderson et al 1974;Anderson et al 1979) was found to fit lung tumor induction results from experiments in several laboratories involving a variety of exposure aerosols.…”

Section: Introductionmentioning

confidence: 99%

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Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution

Diel

Mewhinney

1983

Radiat Environ Biophys

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Syrian hamsters inhaled a monodisperse aerosol of 238PuO2 and were serially sacrificed to study the microscopic distribution of particles, tissue at risk and dose as a function of time after exposure. The distribution of dose and tissue at risk around single particles in lung and the changes in distribution of particles with time have been reported previously. In the present paper, these measurements are applied to the computation of tissue-at-risk and radiation-dose-rate distributions within the lungs of Syrian hamsters. Based on these results, airway epithelium is irradiated at the same levels as other lung tissue and does not require separate consideration on the basis of dose to tissue. Incorporation of the measured microscopic radiation dose distribution into existing dose-effect models allowed data on lung tumor induction in Syrian hamsters from several laboratories to be adequately described by a model fit to data from a single laboratory.

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Section: Particle Distribution In Hamsterssupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Particle Distribution In Hamstersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution

Diel

Mewhinney

1983

Radiat Environ Biophys

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“…In an imaginative series of studies at Los Alamos Scientific Laboratories, Syrian golden hamsters were intravenously injected with microspheres of 10 ,um diameter containing Pu and ZrO2 ceramic (51,67,68). The microspheres lodged in the pulmonary capillaries and remained immobile for the life of the hamster.…”

Section: Hamstersmentioning

confidence: 99%

Radionuclide injury to the lung.

Dagle¹,

Sanders²

1984

Environ Health Perspect

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Radionuclide injury to the lung has been studied in rats, hamsters, dogs, mice and baboons. Exposure of the lung to high dose levels of radionuclides produces a spectrum of progressively more severe functional and morphological changes, ranging from radiation pneumonitis and fibrosis to lung tumors. These changes are somewhat similar for different species. Their severity can be related to the absorbed radiation dose (measured in rads) produced by alpha, beta or gamma radiation emanating from various deposited radionuclides. The chemicophysical forms of radionuclides and spatial-temporal factors are also important variables. As with other forms of injury to the lung, repair attempts are highlighted by fibrosis and proliferation of pulmonary epithelium. Lung tumors are the principal late effect observed in experimental animals following pulmonary deposition of radionuclides at dose levels that do not result in early deaths from radiation pneumonitis or fibrosis. The predominant lung tumors described have been of epithelial origin and have been classified, in decreasing frequency of occurrence, as adenocarcinoma, bronchioloalveolar carcinoma, epidermoid carcinomas and combined epidermoid and adenocarcinoma. Mesothelioma and fibrosarcoma have been observed in rats, but less commonly in other species. Hemangiosarcomas were frequency observed in dogs exposed to beta-gamma emitters, and occasionally in rats exposed to alpha emitters. These morphologic changes in the lungs of experimental animals were reviewed and issues relevant to the prediction of human hazards discussed.

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Lung tumors from PuO₂‐ZrO₂ aerosol particles in syrian hamsters

Thomas

Smith

1979

Intl Journal of Cancer

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Syrian golden hamsters were given PuO2/ZrO2 particles via inhalation and/or Pu-laden ZrO2 ceramic 10-micron diameter microspheres lodged in the capillary bed of the lung. The mean initial lung burdens ranged from 8 nCi to 143 nCi for the six experimental groups of animals. Significant numbers of primary lung tumors (5-50% per group) were induced in those animals that received inhalation exposures. Additional alpha radiation administered via Pu-laden intravenous microspheres had little or no effect on tumorigenesis or the production of non-neoplastic, degenerative changes in the respiratory tract.

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Tumorigenic Hazard of Particulate α Activity in Syrian Hamster Lungs

Cited by 8 publications

References 13 publications

Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution

Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution

Radionuclide injury to the lung.

Lung tumors from PuO₂‐ZrO₂ aerosol particles in syrian hamsters

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Tumorigenic Hazard of Particulate α Activity in Syrian Hamster Lungs

Cited by 8 publications

References 13 publications

Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution

Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution

Radionuclide injury to the lung.

Lung tumors from PuO2‐ZrO2 aerosol particles in syrian hamsters

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Lung tumors from PuO₂‐ZrO₂ aerosol particles in syrian hamsters