Progress of Fabrication and Applications of Electrospun Hierarchically Porous Nanofibers

Liu, Ranran; Hou, Lanlan; Yue, Guichu; Li, Huaike; Zhang, Jiesan; Liu, Jing; Miao, Beibei; Wang, Nü; Bai, Jie; Cui, Zhimin; Liu, Tianxi; Zhao, Yong

doi:10.1007/s42765-022-00132-z

Cited by 136 publications

(67 citation statements)

References 156 publications

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“…For example, it is reported that core–shell nanofibers from coaxial electrospinning and Janus nanofibers from side-by-side electrospinning can provide these advanced drug controlled release profiles, with a fast release from the shell section or one side, and an extended release from the core section or another side [ 55 , 56 ]. However, these multiple-fluid electrospinning processes are more difficult to be scaled up and often need more skilled operation skills [ 57 , 58 , 59 , 60 , 61 ]. New facile method is highly desired for producing drug delivery systems that provide drug double-stage release.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

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Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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“…The applied voltages are often between 5 and 30 kV. Syringe pumps are exploited to drive the working fluids to the spinneret in a quantitative manner ( Liu et al, 2022c ; Liu et al, 2022a ). The spinneret is the most innovative section in an electrospinning apparatus ( Wang M. et al, 2022 ; Liu et al, 2022b ).…”

Section: Electrospun Glucose Sensorsmentioning

confidence: 99%

Electrospun nanofiber-based glucose sensors for glucose detection

Zhang

Liu

et al. 2022

Front. Chem.

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Diabetes is a chronic, systemic metabolic disease that leads to multiple complications, even death. Meanwhile, the number of people with diabetes worldwide is increasing year by year. Sensors play an important role in the development of biomedical devices. The development of efficient, stable, and inexpensive glucose sensors for the continuous monitoring of blood glucose levels has received widespread attention because they can provide reliable data for diabetes prevention and diagnosis. Electrospun nanofibers are new kinds of functional nanocomposites that show incredible capabilities for high-level biosensing. This article reviews glucose sensors based on electrospun nanofibers. The principles of the glucose sensor, the types of glucose measurement, and the glucose detection methods are briefly discussed. The principle of electrospinning and its applications and advantages in glucose sensors are then introduced. This article provides a comprehensive summary of the applications and advantages of polymers and nanomaterials in electrospun nanofiber-based glucose sensors. The relevant applications and comparisons of enzymatic and non-enzymatic nanofiber-based glucose sensors are discussed in detail. The main advantages and disadvantages of glucose sensors based on electrospun nanofibers are evaluated, and some solutions are proposed. Finally, potential commercial development and improved methods for glucose sensors based on electrospinning nanofibers are discussed.

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“…These nanofibrous membranes have an extracellular matrix-like structure that provides a template for the proliferation of skin cells, thereby stimulating tissue regeneration. Electrospun nanofiber membranes have high porosity and large specific surface area, which can absorb the wound exudate in time, promote the transfer of nutrients in the wound environment, maintain the gas exchange at the wound site, and prevent the wound from dehydration [ 45 , 46 ]. In addition, the nanofiber membrane is soft, can be tailored to the size and shape of the wound, and is highly pliable; the nanofiber membrane protects the wound on a physical level and is able to protect the wound from other injuries and invasion by foreign microorganisms [ 47 , 48 , 49 , 50 , 51 ].…”

Section: Electrospinning Technologymentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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Progress of Fabrication and Applications of Electrospun Hierarchically Porous Nanofibers

Cited by 136 publications

References 156 publications

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Electrospun nanofiber-based glucose sensors for glucose detection

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

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