Prophylactic effect of green tea and Nigella sativa extracts against fenitrothion-induced toxicity in rat parotid gland

Korany, Nahed Sedky; Ezzat, Bassant A.

doi:10.1016/j.archoralbio.2011.05.006

Cited by 17 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They suggested that this effect may be due to the antioxidant, antitoxin, and chemoprotective properties of different components of green tea. Korany and Ezzat [40] compared between green tea and black seed, Nigella sativa , extracts in the prevention of fenitrothion-induced toxicity on rat parotid salivary gland. They concluded that the administration of natural antioxidants could be of beneficial effect on the prevention of cytotoxicity induced by organophosphorous compounds and green tea showed more promising results than that of black seed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tea (Camellia sinensis) and Olive (Olea europaeaL.) Leaves Extracts on Male Mice Exposed to Diazinon

Al-Attar

Zeid

2013

BioMed Research International

View full text Add to dashboard Cite

The present study was aimed to evaluate the effects of tea and olive leaves extracts and their combination in male mice intoxicated with a sublethal concentration of diazinon. Exposure of mice to 6.5 mg/kg body weight of diazinon for seven weeks resulted in statistical increases of serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase, creatine kinase, creatinine, glucose, triglycerides, and cholesterol, while the value of serum total protein was declined. Treating diazinon-intoxicated mice with tea and olive leaves extracts or their combination significantly attenuated the severe alterations in these hematobiochemical parameters. Moreover, the results indicated that the supplementation with combination of tea and olive leaves extracts led to more attenuation effect against diazinon toxicity. Additionally, these new findings suggest that the effect of tea and olive leaves extracts and their combination against toxicity of diazinon may be due to antioxidant properties of their chemical constituents. Finally, the present study indicated that the extracts of tea and olive leaves and their combination can be considered as promising therapeutic agents against hepatotoxicity, cardiotoxicity, nephrotoxicity, and metabolic disorders induced by diazinon and maybe by other toxicants and pathogenic factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Tea (Camellia sinensis) and Olive (Olea europaeaL.) Leaves Extracts on Male Mice Exposed to Diazinon

Al-Attar

Zeid

2013

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…post-treatment Exp. 3: received NSO (1 ml/kg orally) [16] All administrations were scheduled and carried out during the light phase between 7:00 and 9:00 am. All groups contained six rats each and treatments continued for fourteen consecutive days.…”

Section: Treatments Schedulementioning

confidence: 99%

Protective Effect of Nigella Sativa (Black Caraway (Oil on Oral Dichlorvos Induced Hematological, Renal and Nonspecific Immune System Toxicity in Wistar Rats

Ajao

Sansa

Imam

et al. 2017

IJT

View full text Add to dashboard Cite

show abstract

“…In a similar study, Sai et al found that green tea acted as an anti-promoter against PCP-induced mouse hepatocarcinogenesis via its ability to prevent down-regulation of gap junction protein 1c (GJIC) [48]. Korany et al [44] also showed that green tea pretreatment significantly reduced histopathological alterations induced by the pesticide fenitrothion. These studies, though limited in number, further elucidate the possible role of green tea in the inhibition of pesticide-induced carcinogenesis.…”

Section: Green Tea Modulates Pesticide-related Damage or Diseasementioning

confidence: 99%

Therapeutic properties of green tea against environmental insults

Chen¹,

Zhao

et al. 2017

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Pesticides, smoke, mycotoxins, polychlorinated biphenyls, and arsenic are the most common environmental toxins and toxicants to humans. These toxins and toxicants may impact on human health at the molecular (DNA, RNA, or protein), organelle (mitochondria, lysosome, or membranes), cellular (growth inhibition or cell death), tissue, organ, and systemic levels. Formation of reactive radicals, lipid peroxidation, inflammation, genotoxicity, hepatotoxicity, embryotoxicity, neurological alterations, apoptosis, and carcinogenic events are some of the mechanisms mediating the toxic effects of the environmental toxins and toxicants. Green tea, the non-oxidized and non-fermented form of tea that contains several polyphenols, including green tea catechins, exhibits protective effects against these environmental toxins and toxicants in preclinical studies and to a much-limited extent, in clinical trials. The protective effects are collectively mediated by antioxidant, anti-inflammatory, anti-mutagenic, hepato- and neuroprotective, and anti-carcinogenic activities. In addition, green tea modulates signaling pathway including NFκB and ERK pathways, preserves mitochondrial membrane potential, inhibits caspase-3 activity, down-regulates pro-apoptotic proteins, and induces the phase II detoxifying pathway. The bioavailability and metabolism of green tea and its protective effects against environmental insults induced by pesticides, smoke, mycotoxins, polychlorinated biphenyls, and arsenic are reviewed in this paper. Future studies with emphasis on clinical trials should identify biomarkers of green tea intake, examine the mechanisms of action of green tea polyphenols, and investigate potential interactions of green tea with other toxicant-modulating dietary factors.

show abstract

Prophylactic effect of green tea and Nigella sativa extracts against fenitrothion-induced toxicity in rat parotid gland

Cited by 17 publications

References 33 publications

Effect of Tea (Camellia sinensis) and Olive (Olea europaeaL.) Leaves Extracts on Male Mice Exposed to Diazinon

Effect of Tea (Camellia sinensis) and Olive (Olea europaeaL.) Leaves Extracts on Male Mice Exposed to Diazinon

Protective Effect of Nigella Sativa (Black Caraway (Oil on Oral Dichlorvos Induced Hematological, Renal and Nonspecific Immune System Toxicity in Wistar Rats

Therapeutic properties of green tea against environmental insults

Contact Info

Product

Resources

About