Prostaglandins in Clinical Treatment of Gastroduodenal Mucosal Lesions: A Review

A, Aly

doi:10.3109/00365528709089761

Cited by 25 publications

(12 citation statements)

References 45 publications

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“…In the present study, increase in pH, decrease in free and total acidity, decrease in volume of gastric juice and pepsin concentration were evidenced in ulcerated animals treated with leaves extract of the plant Dalbergia sissoo, which is highly desirable for gastro protection and antiulcer effect. Ulcerated rats showed an alteration in the peptic activity which is in accordance with the previous report 29 . The modification in pepsin concentration on leaves extract of the plant treatment depicts the efficacy of the extract on gastric secretions and it can be assumed due to the direct action on the acid producing cells.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Anti Ulcer Activity of Ethanolic Extract of Dalbergia Sissoo Leaves in Experimental Animals

Baral¹,

Swamy²,

Bhattarai³

et al. 2014

Int. Res. J. Pharm.

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Gastric ulcer is one of the major health problems in developing countries. Furthermore, high cost and of adverse effects are seen with the long term use of allopathic drugs in treatment of ulcer which are diminished by the use of herbal drugs. The aim of this study is to evaluate antiulcer activity of crude extract of Dalbergia sissoo leaves on experimentally induced gastric ulcer in wistar albino rats. Methodology involves screening for antiulcer activity of the plant using pylorus ligation and Indomethacin induced ulcer models in albino rats using 4 groups as; control (Tween 80 1 % v/v solution, 5 ml/kg), standard (Ranitidine 80 mg/kg), 250 mg/kg leaves extract and 500 mg/kg leaves extract given respective doses orally (p.o.). The parameters viz. mean ulcer index, percentage protection, gastric pH, protein, carbohydrate, pepsin, free and total acidity and ratio of total carbohydrates and proteins (TC:TP) were determined. The result showed the significant decrease in mean ulcer index of the leaves extract treated group in both the models compared to control. Furthermore, as obvious from pylorus ligation model the offensive factors like free and total acidity, pepsin content and protein content were decreased to significant levels whereas the defensive factors like total carbohydrate content and TC:TP ratio were increased significantly compared to control in dose dependent manner. The study concluded that leaves extract of Dalbergia sissoo had significant antiulcer activity and was not only effective in reducing the development of gastric ulcer but also increasing the healing of the gastric ulcer in dose dependent manner.

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Section: Discussionsupporting

confidence: 92%

Evaluation of Anti Ulcer Activity of Ethanolic Extract of Dalbergia Sissoo Leaves in Experimental Animals

Baral¹,

Swamy²,

Bhattarai³

et al. 2014

Int. Res. J. Pharm.

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“…It is generally accepted that gastric ulcers result from an imbalance between aggressive factors and the maintenance of the mucosal integrity through endogenous defense mechanisms [18]. The excess gastric formation of prostaglandin (PG) includes both increases in mucosal resistance as well as a decrease in aggressive factors, mainly acid, and pepsin [19]. Acute gastric ulcers were induced in rats by the oral administration of acetylsalicylic acid.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Rameshwari¹,

Ayshwarya²

2017

Asian J Pharm Clin Res

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Objective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats. Methods:To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously. The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index. Results:The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The control animals had ulcers and hemorrhagic streaks, whereas in animals administered with extracts of B. oleracea there was a significant reduction in ulcer index (p˂0.05). Conclusion:This study concluded that methanol extract of B. oleracea var. capitata has healing property of gastric ulcers in albino rats.

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“…Moreover, the inhibition of the COX 1 blocks platelet production of thromboxane, which increases bleeding when an active gastrointestinal bleeding site is present (Sostres et al, 2010). The COX 1 expression in stomach produces prostaglandins (PG) that play a protective role by stimulating the synthesis and secretion of mucus and bicarbonate, by increasing mucosal blood flow and by regulating mucosal cell turnover and repair (Aly, 1987). So, the COX-1-mediated PG synthesis is mainly responsible for maintaining gastric mucosal integrity at baseline.…”

Section: Discussionmentioning

confidence: 99%

Gastro-protective effects of the phenolic acids of Macrotyloma uniflorum (horse gram) on experimental gastric ulcer models in rats

Panda¹,

Suresh²

2015

Food Bioscience

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Prostaglandins in Clinical Treatment of Gastroduodenal Mucosal Lesions: A Review

Cited by 25 publications

References 45 publications

Evaluation of Anti Ulcer Activity of Ethanolic Extract of Dalbergia Sissoo Leaves in Experimental Animals

Evaluation of Anti Ulcer Activity of Ethanolic Extract of Dalbergia Sissoo Leaves in Experimental Animals

Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Gastro-protective effects of the phenolic acids of Macrotyloma uniflorum (horse gram) on experimental gastric ulcer models in rats

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