Protective effect of Myrcia pubipetala Miq. against the alterations in oxidative stress parameters in an animal model of depression induced by corticosterone

Shuster, Anna Lydia; Rocha, Fernanda Emilia; Wayszceyk, Sheila; Lima, Daniela Delwing de; Barauna, Sara Cristiane; Lopes, Bruna Gonçalves; Alberton, Michele Debiasi; Magro, Débora Delwing Dal

doi:10.1016/j.brainres.2021.147725

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…The CORT-induced depression model has a shorter test schedule, with a higher repeatability and success rate, for rapid assessment of antidepressant efficacy, enabling an expedient evaluation, and has been utilized in many studies (5,33,35,36). In depressive mood disorders, continuous changes in the HPA axis are observed, usually associated with stress (32). Therefore, this study induced dysregulation of the HPA axis in male SAMP8 mice by repeated injections of CORT (40 mg/kg/day), which led to depression and anxiety.…”

Section: Resultsmentioning

confidence: 94%

“…Stress hormones such as CORT play a vital role in the development of depression (32,33), and this relationship has been used to develop animal models of the condition (25,34,35). The CORT-induced depression model has a shorter test schedule, with a higher repeatability and success rate, for rapid assessment of antidepressant efficacy, enabling an expedient evaluation, and has been utilized in many studies (5,33,35,36).…”

Section: Resultsmentioning

confidence: 99%

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Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Chou

Huang

et al. 2022

Front. Nutr.

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Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural materials is an urgent need. Therefore, this study used a complex extract of chlorella and lion's mane mushroom and evaluated its antidepressant effects. Six-month-old male senescence-accelerated mice prone-8 (SAMP8) were divided into positive control; negative control; and low, medium, and high-dose groups. All groups were treated with corticosterone (CORT) at 40 mg/Kg/day for 21- days to induce depression in the animals, and the effects of different test substances on animal behavior was observed. The positive control group was intraperitoneally injected with a tricyclic antidepressant (Fluoxetine, as tricyclic antidepressant), the control group was given ddH2O, and the test substance groups were administered test samples once daily for 21 days. The open field test (OFT) and forced swimming test (FST) were applied for behavior analyses of depression animal models. The OFT results showed that the mice in the positive control and the medium-, and high-dose groups demonstrated a significantly prolonged duration in the central area and a significantly increased travel distance. In the FST, the positive control and the medium, and high-dose groups displayed significantly reduced immobility times relative to the control group. The blood analysis results showed significant decreases in triglyceride and blood urea nitrogen levels relative to the positive control and the medium- and high-dose groups. Notably, in the positive control and the medium- and high-dose groups, brain-derived neurotrophic factor (BDNF) increase by more than in the control group. In summary, medium and high dose of extract of chlorella and lion's mane mushroom could improve depression behavior in animals and have the potential to be antidepressant health care products.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Chou

Huang

et al. 2022

Front. Nutr.

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“…Excessive production of ROS leads to oxidative stress which has been implicated in the pathogenesis of depressive disorder. ROS can cause enzyme inhibition, lipid peroxidation and mitochondrial alterations, and these are found in depression pathology ( 61 ). The current finding shows that rats exposed to AFB1 are experiencing anhedonia-like behavior.…”

Section: Resultsmentioning

confidence: 99%

Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats

et al. 2022

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While it is well documented that aflatoxin B1 (AFB1); one of the most toxic food contaminants is linked to the development of depression. However, the mechanism on how it affects the gut and brain health leading to depressive-like behavior remains unclear. This study was conducted to determine the effect of AFB1 on the progression of depressive-like behavior. Thirty-two (n = 32) male Sprague Dawley rats were randomly allocated into four groups: control, low-dose (5 μg AFB1/kg), high-dose (25 μg AFB1/kg) and positive control group; exposed on chronic unpredictable mild stress (CUMS). After 4 weeks of exposure, sucrose preference test (SPT) and force swim test (FST) were used to measure behavioral despair. Fecal samples were selectively cultured to profile the bacteria. Body weight and relative organs weights were compared among groups. AFB1 and CUMS caused reduction in body weight and food intake as well as increased relative weight of adrenal glands, liver, and brain. Rats in AFB1 and CUMS groups had suppressed sucrose preference and prolonged immobility time in FST, wherein this could indicate anhedonia. Besides, fecal count of Lactobacillus spp. was significantly low following AFB1 exposure, with increasing count of Bifidobacterium spp, in comparison to the control. Indeed, further biochemical analysis and metagenomic approach are warranted to explore the underlying mechanisms on the role of gut microbiota dysbiosis and dysregulation of gut-brain axis due to AFB1 neurotoxicity on the progression of depressive-like behavior.

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“…As a result, in the present study, the increased ER stress markers could be the cause of oxidative stress induction. Furthermore, the elevated plasma corticosterone concentration might be another cause of oxidative stress induction 47 – 49 , in the HFD group. The animal and human researches have suggested a connection between X-box binding protein 1 (XBP-1) gene expression and increased glucocorticoid levels 50 , 51 .…”

Section: Discussionmentioning

confidence: 97%

Endoplasmic reticulum stress inhibition ameliorated WFS1 expression alterations and reduced pancreatic islets’ insulin secretion induced by high-fat diet in rats

Binayi

Fahanik-Babaei

Salimi

et al. 2023

Sci Rep

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Endoplasmic reticulum (ER) stress is involved in the development of glucose homeostasis impairment. When ER stress occurs, the unfolded protein response (UPR) is activated to cope with it. One of the UPR components is WFS1 (Wolfram syndrome 1), which plays important roles in ER homeostasis and pancreatic islets glucose-stimulated insulin secretion (GSIS). Accordingly and considering that feeding high-fat food has a major contribution in metabolic disorders, this study aimed to investigate the possible involvement of pancreatic ER stress in glucose metabolism impairment induced by feeding high-fat diet (HFD) in male rats. After weaning, the rats were divided into six groups, and fed on normal diet and HFD for 20 weeks, then 4-phenyl butyric acid (4-PBA, an ER stress inhibitor) was administered. Subsequently, in all groups, after performing glucose tolerance test, the animals were dissected and their pancreases were removed to extract ER, islets isolation and assessment of GSIS. Moreover, the pancreatic ER stress [binding of immunoglobulin protein (BIP) and enhancer-binding protein homologous protein (CHOP)] and oxidative stress [malondialdehyde (MDA), glutathione (GSH) and catalase] biomarkers as well as WFS1 expression level were evaluated. HFD decreased pancreatic WFS1 protein and GSH levels, and enhanced pancreatic catalase activity, MDA content, BIP and CHOP protein and mRNA levels as well as Wfs1 mRNA amount. Accordingly, it increased BIP, CHOP and WFS1 protein levels in the extracted ER of pancreas. In addition, the HFD caused glucose intolerance, and decreased the islets’ GSIS and insulin content. However, 4-PBA administration restored the alterations. It seems that, HFD consumption through inducing pancreatic ER stress, altered WFS1 expression levels, reduced the islets’ GSIS and insulin content and finally impaired glucose homeostasis.

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Protective effect of Myrcia pubipetala Miq. against the alterations in oxidative stress parameters in an animal model of depression induced by corticosterone

Cited by 9 publications

References 26 publications

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats

Endoplasmic reticulum stress inhibition ameliorated WFS1 expression alterations and reduced pancreatic islets’ insulin secretion induced by high-fat diet in rats

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