Protective effects of pineapple (Ananas comosus) on liver and kidney of Wistar rats intoxicated with Doliprane®

Abstract

Effect of pineapple (Ananas comosus) on liver and kidney detoxication was studied in Wistar rats. Rats were treated with paracetamol at the dose of 2 g/kg of body weight per day for 6 weeks and then by Ananas comosus' extract (0.06 -0.12 ml/kg body weight). Administration of paracetamol induced hepatomegaly with a centrolobular necrosis and an increase in kidney weight. Treatment with Ananas comosus' extract induced a reduction of hepatic lesions but no effect on kidney. These data suggest that Ananas comosus extract treatment reduces hepatotoxicity of paracetamol in Wistar rats.

Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

“…A. comosus is by far the most economically important plant in the Bromeliaceae family with an edible fruit (Coppens d'Eeckenbrugge & Leal 2003). Ananas comosus is reported to possess several medicinal properties such as antidiabetic (Weidong et al 2005), antitumour (Kalra et al 2008), antioxidant, hepatoprotective (Dougnon et al 2009), platelet aggregation (Bhattacharyya 2008), anti-helmintic (Gillian et al 2004), anti-inflammatory (Eric et al 2005) and immunomodulatory (Engwerda et al 2001) activities. Various pharmacologically active phytochemicals present in this plant are ananasate, b-sitosterol, chlorogenic acid, rutin, naringenin (Makoto et al 2007), bromelain (Eric et al 2005) glycosides, flavonoids (Chao et al 2007) and neurotransmitters, such as serotonin (Feldman & Lee 1985), dopamine, adrenaline and non-adrenaline (Odjakova & Hadjiivanova 1997).…”

Effect of Hydroalcoholic Extracts of Parkinsonia Aculeata L. And Ananus Comosus L. On Oxotremorine Induced Parkinsonism in Wistar Albino Rats

“…It contains various pharmacologically active phytoconstituents such as ananasate, beta-sitosterol, Chlorogenic acid, rutin, naringenin, bromelin, glysocides, flavonoids and neurotransmitters [17][18][19] . Annanas cosmosus L. reported to possess some medicinal properties such as anti diabetic activity, 20 antitumor property 21 anti-oxidant action 22 , antiinflammatory activity 23 , immuno-modulatory activity 24 hepatoprotective action 25 platelet aggregation activity and anthelmintic activity. 26 Current pharmaco therapeutics for Parkinson's disease are L-dopa, carbidopa, Mono-amino oxidase inhibitors and anti-cholinergic drugs.…”