Protein interaction with a Pluronic-modified poly(lactic acid) Langmuir monolayer

Amphiphilic multiblock copolymers of PLLA, PEO and PPO blocks: Synthesis, properties and cell affinity

“…PEO-b-PPO copolymers are commonly referred to as modifiers of thermal and mechanical PLLA properties, as a plasticizer [14], or as modifiers of the PLLA surface character, as a hydrophilic additive [15]. Lee 2 ] at 160°C to manufacture drawn filaments for sutures.…”

Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses

“…Poly(ethylene glycol) (PEG) is a widely used modifier agent with sufficient biocompatibility, rendering the surface protein resistant [4][5][6]. The chemical modification of PLGA is usually based on controlled hydrolysis of the polymer since there are no reactive functional groups present.…”

“…This simple and appropriate method could address the stability issues of physically adsorbed layers. The surface modifying effect of Pluronics with different compositions blended with PLGA was studied in previous works [5,22].…”

Poly(Lactic Acid) Blends

“…This segregation appeared in the blend in all blend compositions, and its degree increased with increase in Pluronic content [223]. Kiss et al [225,226] reported that a decrease in contact angle with an increase in Pluronic contact indicated more wettability for the blends than for neat PLA. They also reported that the concentration of Pluronic on the surface was higher than in the bulk and that the amount of Pluronic on the surface varied with the type and content of Pluronic in the blend [225].…”

“…The absorption of BSA in the blend decreased compared to that in neat PLA [225]. With the presence of longer PEO chains in Pluronic, a considerable decrease in BSA absorption was obtained [226]. For controlled release study, incorporation of more hydrophobic (PPO) than hydrophilic (PEO) portions in the blend enabled reduction in the initial burst of BSA, a model drug, due to lower water absorption.…”