Real-time multi-functional optical coherence tomography

Park, B. Hyle; Pierce, Mark C.; Cense, Barry; Boer, Johannes F. de

doi:10.1364/oe.11.000782

Cited by 160 publications

(129 citation statements)

References 26 publications

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“…This changed with the introduction of FD modalities, 18,114 which paved the way for the exciting developments in optical angiography that we see today. Methods based on FD OCT soon adapted the phase approaches from TD OCT. 115,116 However, the differences of the data acquisition process and optical setup in FD versus TD OCT opened a large playfield for many new approaches to optical angiography. For example, spectrometer-based FD OCT suffers from fringe washout and sensitivity loss when imaging moving structures.…”

Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

433

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

433

264

View full text Add to dashboard Cite

show abstract

“…Data acquisition and processing software based on thread architecture similar to the one described in Ref. [12] is used to handle functionalities such as triggering, acquisition, processing, displaying and saving simultaneously. The computer used is a dualcore processor (Intel Pentium IV Xeon) that controls the system through three National An SLO fundus imaging and lateral tracking system (~10μm RMS) developed by Physical Sciences Inc. [7,8,13,14] is integrated into the SD-OCT system and is currently controlled by a separate computer.…”

Section: Methodsmentioning

confidence: 99%

Three dimensional tracking for volumetric spectral-domain optical coherence tomography

Maguluri¹,

Mujat²,

Park³

et al. 2007

Opt. Express

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Abstract:We present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking system is implemented through a real-time dynamic feedback mechanism to compensate for motion artifact in the axial direction. Active monitoring of the retina and adapting the reference arm of the interferometer allowed the whole thickness of the retina to be stabilized to within ±100 µm. We achieve a relatively constant SNR from image to image by stabilizing the image of the retina with respect to the depth dependent sensitivity of SD-OCT. The depth tracking range of our system is 5.2 mm in air and the depth is adjusted every frame. Enhancement in the stability of the images with the depth-tracking algorithm is demonstrated on a healthy volunteer.

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“…The OCT system used in the eye study has been described previously [20,21]. In order to compare data obtained with and without AR, we examined retinal images without AR and retinal images with AR obtained from the same location.…”

Section: An Example Of the Imaging Depth Afforded By This Technology mentioning

confidence: 99%

Adaptive ranging for optical coherence tomography

Iftimia¹,

Bouma²,

Boer³

et al. 2004

Opt. Express

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At present, optical coherence tomography systems have a limited imaging depth or axial scan range, making diagnosis of large diameter arterial vessels and hollow organs difficult. Adaptive ranging is a feedback technique where image data is utilized to adjust the coherence gate offset and range. In this paper, we demonstrate an adaptive optical coherence tomography system with a 7.0 mm range. By matching the imaging depth to the approximately 1.5 mm penetration depth in tissue, a 3 dB sensitivity improvement over conventional imaging systems with a 3.0 mm imaging depth was realized.

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Real-time multi-functional optical coherence tomography

Cited by 160 publications

References 26 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Three dimensional tracking for volumetric spectral-domain optical coherence tomography

Adaptive ranging for optical coherence tomography

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