Recent advancements in fabrication of nanomaterial based biosensors for diagnosis of ovarian cancer: a comprehensive review

Sha, Rinky; Badhulika, Sushmee

doi:10.1007/s00604-020-4152-8

Cited by 40 publications

(15 citation statements)

References 98 publications

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“…In this group, TP53 mutation and MUC16 mutation were the two most common types of gene mutation. MUC16 is a member of the mucin family glycoprotein, which has been used as a tumor marker in the early diagnosis of ovarian cancer and other tumors [ 28 , 29 ]. MUC16 can promote tumorigenesis in ovarian cancer and play a role in tumor proliferation [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of genomic and immunological profiles in Chinese and Western hepatocellular carcinoma populations

et al. 2021

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In this study, we explored the genomic and immune cell infiltration profiles among four distinct Hepatocellular carcinoma (HCC) types. This study included 100 patients (all tumors and adjacent liver tissues received WES sequencing) with HCC from the West China Hospital (WCH) and patients were divided into WCH-HBV-HCC group and WCH-NonHBV-HCC group. Additionally, this study included 106 HBV-related HCC (TCGA-HBV-HCC) and 69 alcoholic HCC (TCGA-Alcol-HCC) patients from the TCGA. We analyzed the high-frequency gene mutation, copy number variation (CNV), mutation spectrum, signatures and immune cell infiltration of these four groups. This study showed significant differences in gene mutation and CNV level among four HCC groups. Compared to genomic level, there is no significant difference between TCGA-HBV-HCC and TCGA-Alcol-HCC groups in fractions of tumor-infiltrating immune cells. According to the status of immune cell infiltration, patients were classified into immune-HIGH, immune-MIX and immune-LOW group, respectively. In the WCH-HBV-HCC and TCGA-HBV-HCC groups, more patients in the Immune-LOW group had TP53 mutation. Except for TP53, neither the other gene mutation nor tumor mutation burden was found to be associated with immune cell infiltration in the WCH-HBV-HCC, TCGA-HBV-HCC and TCGA-Alcol-HCC groups. In the CNV level, we found that samples with low immune infiltrate had higher number of deleted or amplified genes in the TCGA-HBV-HCC and TCGA-Alcol-HCC groups. We found comprehensive genomic heterogeneity among four HCC groups. The total gene CNV level, not the mutational burden of HCC, is associated with immune cell infiltration in HCC. TP53 mutation may injury the immune response of the HBV-related HCC.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of genomic and immunological profiles in Chinese and Western hepatocellular carcinoma populations

et al. 2021

Aging

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“…It works by making a chemical reaction in which electrons jump from their ground state to an excited state, and then return to the ground state to emit light [ 68 ]. Many chemiluminescence-based microfluidic detection devices have been reported [ 69 , 70 ]. The combination of chemiluminescence and low-cost μPADs has been reported [ 71 , 72 ].…”

Section: μPads Based On Different Detection Methodsmentioning

confidence: 99%

Research Progress and Future Trends of Microfluidic Paper-Based Analytical Devices in In-Vitro Diagnosis

et al. 2022

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In vitro diagnosis (IVD) has become a hot topic in laboratory research and achievement transformation. However, due to the high cost, and time-consuming and complex operation of traditional technologies, some new technologies are being introduced into IVD, to solve the existing problems. As a result, IVD has begun to develop toward point-of-care testing (POCT), a subdivision field of IVD. The pandemic has made governments and health institutions realize the urgency of accelerating the development of POCT. Microfluidic paper-based analytical devices (μPADs), a low-cost, high-efficiency, and easy-to-operate detection platform, have played a significant role in advancing the development of IVD. μPADs are composed of paper as the core material, certain unique substances as reagents for processing the paper, and sensing devices, as auxiliary equipment. The published reviews on the same topic lack a comprehensive and systematic introduction to μPAD classification and research progress in IVD segmentation. In this paper, we first briefly introduce the origin of μPADs and their role in promoting IVD, in the introduction section. Then, processing and detection methods for μPADs are summarized, and the innovative achievements of μPADs in IVD are reviewed. Finally, we discuss and prospect the upgrade and improvement directions of μPADs, in terms of portability, sensitivity, and automation, to help researchers clarify the progress and overcome the difficulties in subsequent μPAD research.

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“…Especially in this specific field, such errors must be minimized and procedures must reach high levels of accuracy. One of the most lethal types of cancer is ovary cancer, which is commonly diagnosed by biomarkers such as CA125, Mucin 1, HE4, and others, which may be present in the bloodstream [156]. However, there is a latent need for less expensive, more straightforward, and portable diagnostic tools for the timely diagnosis of ovarian as well as other types of cancer [157,158].…”

Section: Nanomaterial-based Biosensorsmentioning

confidence: 99%

Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

et al. 2021

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Among the many biological entities employed in the development of biosensors, enzymes have attracted the most attention. Nanotechnology has been fostering excellent prospects in the development of enzymatic biosensors, since enzyme immobilization onto conductive nanostructures can improve characteristics that are crucial in biosensor transduction, such as surface-to-volume ratio, signal response, selectivity, sensitivity, conductivity, and biocatalytic activity, among others. These and other advantages of nanomaterial-based enzymatic biosensors are discussed in this work via the compilation of several reports on their applications in different industrial segments. To provide detailed insights into the state of the art of this technology, all the relevant concepts around the topic are discussed, including the properties of enzymes, the mechanisms involved in their immobilization, and the application of different enzyme-derived biosensors and nanomaterials. Finally, there is a discussion around the pressing challenges in this technology, which will be useful for guiding the development of future research in the area.

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Recent advancements in fabrication of nanomaterial based biosensors for diagnosis of ovarian cancer: a comprehensive review

Cited by 40 publications

References 98 publications

Comprehensive analysis of genomic and immunological profiles in Chinese and Western hepatocellular carcinoma populations

Comprehensive analysis of genomic and immunological profiles in Chinese and Western hepatocellular carcinoma populations

Research Progress and Future Trends of Microfluidic Paper-Based Analytical Devices in In-Vitro Diagnosis

Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

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