Rumex japonicus Houtt. alleviates dextran sulfate sodium-induced colitis by protecting tight junctions in mice

Kim, Hee-Young; Jeon, Hyongjun; Bae, Chang Hoon; Lee, Yukyoung; Kim, Hyungwoo; Kim, Seungtae

doi:10.1016/j.imr.2020.02.006

Cited by 18 publications

(21 citation statements)

References 42 publications

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“…A possible explanation for the oral bioavailability of both LMWoversulfated heparin and PPS could be their ability to induce increased intestinal epithelial permeability. Such an interpretation agrees with the finding that oral administration of dextran sulfate, a highly negatively charged polysaccharides such as LMWoversulfated heparin and PPS, is associated with loss of occluded ZO-1 in the tight junction complex (TJ) [ (Kim et al, 2020).…”

Section: Methodssupporting

confidence: 88%

“…Thus, the use of oral PPS to suppress hepcidin seems feasible, offering a promising strategy to complement subcutaneous injection of PPS, especially in chronic treatment, but requires further study. For interstitial cystitis, the recommended oral treatment is 400 mg of PPS daily for a long period (186 months) which is well tolerated (Kim et al, 2020), so it may be interesting, in the future, to try chronic treatment in mice with lower concentrations than those used in acute care. At present, subcutaneous PPS injection appears to be very effective in reducing hepcidin expression in terms of drug absorption, dose (much lower than oral administration), and negligible side effects.…”

Section: Methodsmentioning

confidence: 99%

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Non-Pharmacological Interventions for Anemia Treatment: Systematic Review

Putri

Budu

Gemini

et al. 2021

MIPHMP

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The global prevalence of anemia in non-pregnant women, of childbearing age, is estimated at 29.0% and is more common in low- and middle-income countries, women belonging to low socioeconomic strata. iron deficiency can cause direct or risky disability. To determine the effectiveness of Non-Pharmacological Interventions for the treatment of anemia. The method used is with the help of electronic databases from journals that have been published through PubMed, Proquest, EBSCOhost, and Science Direct as many as 6 articles were reviewed from 1186 articles. The 6 articles reviewed in this study with varied respondents using patients, male rats, nurses, Sprague-Dawley (SD) Rattus norvegicus Domestica, bovine serum, premature neonates. Non-pharmacological interventions developed in the treatment of anemia in both human and animal samples as well as the development of treatment and laboratory examinations in the treatment of anemia are Nursing Delirium Screening scale, Hepcidin expression, pain identification, HM10760A, Divalent metal transporter DMT1/SLC11A2, conservative management.

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Section: Methodssupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Non-Pharmacological Interventions for Anemia Treatment: Systematic Review

Putri

Budu

Gemini

et al. 2021

MIPHMP

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“…In fact, roots of the genus Rumex were often reported to be effective against gastrointestinal diseases [28] . In addition, according to RRR phytochemical screening results, its profile, with condensed tannins, p‐ coumaric acid, chlorogenic acids and ECGC, may explain the excellence of this organ for this activity.…”

Section: Resultsmentioning

confidence: 99%

“…However, tight junctions (TJ) are crucial for intestinal epithelium integrity, and some flavonoids such as EGCG, [31] as well as R. japonicus extract, [28] have been reported to exhibit anti‐inflammatory activity and protective effects on intestinal TJ barrier functions, ensuring the improvement of disorganized intestinal architecture by regulating the expressions of Zonula Occludens‐1, occludin and claudin‐2, which may be related to inhibition of pro‐inflammatory cytokines, such as TNF‐α [28] …”

Section: Resultsmentioning

confidence: 99%

Comparison of Phytochemical Profile and Bioproperties of Methanolic Extracts from Different Parts of Tunisian Rumex roseus

Chelly

Occhiuto

et al. 2021

Chemistry & Biodiversity

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The genus Rumex (Polygonaceae) is distributed worldwide and the different species belonging to it are used in traditional medicine. The present study aimed at the evaluation of the phytochemical profile and the biochemical properties of methanolic extracts from different parts (roots, stems, and leaves) of Rumex roseus, a wild local Tunisian plant traditionally used as food. The phytochemical analysis on the extracts was performed using standard colorimetric procedures, HPLC‐DAD, and HPLC‐DAD‐ESI‐MS; then, several in vitro cell‐free assays have been used to estimate their antioxidant/free radical scavenging capability (TAC‐PM, DPPH, TEAC, FRAP, ORAC, SOD‐like activity, and HOCl‐induced albumin degradation). Additionally, anti‐inflammatory effect of these extracts was evaluated in an in vitro model of acute intestinal inflammation in differentiated Caco‐2 cells. The results showed that the methanolic extracts from stems and, especially, leaves contain substantial amounts of flavones (apigenin and luteolin, together with their derivatives), while the extract from roots is characterized by the presence of tannins and quinic acid derivatives. All the extracts appeared endowed with excellent antioxidant/free radical scavenging properties. In particular, the extract from roots was characterized by a remarkable activity, probably due to its different and peculiar polyphenolic composition. Furthermore, both Rumex roseus roots and stems extracts demonstrated an anti‐inflammatory effect in intestinal epithelial cells, reducing TNF‐α‐induced gene expression of IL‐6 and IL‐8. In conclusion, R. roseus methanolic extracts have shown to be potential sources of bioactive compounds to be used in the prevention and treatment of pathologies related to oxidative stress and inflammation.

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“…For example, under inflammatory conditions, a damaged tight-junction barrier can increase paracellular permeability and cause cell damage, such as erosion, ulcers, and apoptosis. It can also stimulate the release of pro-inflammatory cytokines, such as TNF-α and IFN-γ, ultimately worsening the inflammation [ 42 , 43 ]. It has been reported that cell-cycle arrest can also cause cell apoptosis in response to DNA damage [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Analysis of LncRNA in Bovine Mammary Epithelial Cell Injuries Induced by Escherichia Coli and Staphylococcus Aureus

Lin

Zhu

Hao

et al. 2021

IJMS

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Escherichia coli and Staphylococcus aureus are two common pathogenic microorganisms that cause mastitis in dairy cows. They can cause clinical mastitis and subclinical mastitis. In recent studies, lncRNAs have been found to play an important role in the immune responses triggered by microbial inducers. However, the actions of lncRNAs in bovine mastitis remain unclear. The purpose of this study was to investigate the effects of bovine mammary epithelial cell injuries induced by treatment with E. coli and S. aureus, and to explore the lncRNA profile on cell injuries. The lncRNA transcriptome analysis showed a total of 2597 lncRNAs. There were 2234 lncRNAs differentially expressed in the E. coli group and 2334 in the S. aureus group. Moreover, we found that the E. coli and S. aureus groups of maternal genes targeted signaling pathways with similar functions according to KEGG and GO analyses. Two lncRNA–miRNA–mRNA interaction networks were constructed in order to predict the potential molecular mechanisms of regulation in the cell injuries. We believe that this is the first report demonstrating the dysregulation of lncRNAs in cells upon E. coli and S. aureus infections, suggesting that they have the potential to become important diagnostic markers and to provide novel insights into controlling and preventing mastitis.

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Rumex japonicus Houtt. alleviates dextran sulfate sodium-induced colitis by protecting tight junctions in mice

Cited by 18 publications

References 42 publications

Non-Pharmacological Interventions for Anemia Treatment: Systematic Review

Non-Pharmacological Interventions for Anemia Treatment: Systematic Review

Comparison of Phytochemical Profile and Bioproperties of Methanolic Extracts from Different Parts of Tunisian Rumex roseus

Genome-Wide Analysis of LncRNA in Bovine Mammary Epithelial Cell Injuries Induced by Escherichia Coli and Staphylococcus Aureus

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