Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome

Westergaard-Nielsen, Marie; Godballe, Christian; Eriksen, Jesper Grau; Larsen, Stine Rosenkilde; Kiss, Katalin; Agander, Tina Klitmøller; Ulhøi, Benedicte Parm; Charabi, Birgitte; Klug, Tejs Ehlers; Jacobsen, Helle J.; Johansen, Jørgen; Kristensen, Claus Andrup; Andersen, Elo; Andersen, Maria; Andreasen, Simon; Bjørndal, Kristine

doi:10.1007/s00405-020-06205-2

Cited by 36 publications

(53 citation statements)

References 37 publications

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“…In our cohort, the lymph node involvement rate of the patients with ACC was 7.6% which is similar with some other publications 10,33 . In the current study, the rate of perineural invasion was found to be 33.9%, as similar with a very large patient-numbered study by Westergaard-Nielsen et al 5 . While ACC histology may show local recurrence by neural invasion, remarkably, in our study, ACC histology was not found to be a factor that reduces local control as in the study of Terhaard et al 34 .…”

Section: Discussionsupporting

confidence: 92%

“…In recent study, 10-year, DFS rate was 38.8%. Similarly, this rate ranges between 37% and 69% in various studies 5,14,16,29,30 . Thus, the DFS rate, in our study, was found to be compatible with the literature.…”

Section: Discussionmentioning

confidence: 90%

“…Also, minor salivary glands are the source of SGCs, representing for 9-23% of all salivary gland tumors. The most common location of minor salivary glands are within the mucosa of the hard palate [5][6][7] . However, parotid gland tumors are less likely to be malignant compared to other major and minor salivary gland tumors 1 .…”

Section: Introduction U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

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Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy

DUZOVA¹,

Turkan²

2021

NKTD

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Introduction: To evaluate the variables affecting prognostic factors in patients with salivary gland cancer who have received surgery followed by radiotherapy. Methods: Fifty-three patients with major and minor salivary gland cancer who treated with curative surgery and postoperative radiotherapy between 1993 to 2011. We evaluated with regard to overall survival, locoregional recurrence-free survival, disease free survival, distant metastases free survival. Results: The median follow-up period was 40 (8-174) months. The rates of local control, distant metastasis-free, disease free survival and overall survival after 10 years were 65%, 57,7%, 38,8%, and 48,2%, respectively. In univariate analysis, histological subtype, histologic grade, extraglandular extension and delivered dose of RT were found to be as prognostic factors affecting on locoregional recurrence-free survival; gender, histological subtype, extraglandular extension influenced disease-free survival; overall survival was only affected by age. In multivariate analysis, locoregional recurrence-free survival was affected by histologic grade, and dose of RT(60 Gy< better prognosis); distant metastasis-free survival was affected by histological subtype; disease-free survival was affected by histological subtype, histologic grade, lymph node status; overall survival was affected by lymph node status, extraglandular extension and dose of RT (60 Gy< better prognosis). Conclusion: Several prognostic factors affecting local control, distant metastases, and overall survival were found. Postoperative radiotherapy is an affective treatment modality that increases local control and overall survival in patients with Salivary Gland Carcinoma at doses over 60 Gy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Section: Introduction U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

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Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy

DUZOVA¹,

Turkan²

2021

NKTD

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“…The median age by the time of initial tumor diagnosis and the slight predominance of the male gender is in accordance with two large retrospective cohorts encompassing different entities of SGC, reporting overall median ages of 58 and 63 years and proportions of male patients to be 52.0% and 58.5%, respectively [6,7]. Similar to one of the largest studies on SGC by Terhaard et al on behalf of the Dutch Head and Neck Oncology Cooperative Group retrospectively including 565 patients [7], and a follow-up study by Westergaard-Nielsen et al including 1601 SGC patients [27], the tumors in our cohort were more likely to be diagnosed at T1/ T2-stage and N0-stage without signs of distant metastases. Furthermore, in this cohort, AdCC, ACA and MEC were the predominant histological subtypes, in accordance with the literature [7].…”

Section: Discussionsupporting

confidence: 86%

Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center

Grün

Winkelmann

Rödel

et al. 2021

Eur Arch Otorhinolaryngol

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Background Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence. Methods Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and outcome was assessed. Results Patients received surgery (n = 65), surgery followed by (chemo-)radiotherapy (n = 56), or primary (chemo-)radiotherapy (n = 6). Injury to the cranial nerves or their branches was the most frequent surgical complication affecting 40 patients (33.1%). Ten year overall and progression-free survival rates were 73.2% and 65.4%, respectively. Parotid tumor site, advanced tumor, and positive nodal stage remained independent negative prognostic factors for overall survival, loco-regional and distant tumor control in multivariate analysis. Conclusions Optimizing treatment strategies for SGC, depending on distinct clinicopathological factors, remains challenging due to the low incidence rates of the disease.

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“…Parotid gland carcinoma constitutes only 1–3% of all head and neck cancers, 1‐4 and clinical studies are difficult to perform because the disease is rare and heterogeneous. Parotid gland carcinomas are histologically categorized into 22 subtypes with different biological behaviors and malignancy grades 5 that affect disease outcomes and prognoses 1,5‐7 …”

Section: Introductionmentioning

confidence: 99%

Prognostic scoring models in parotid gland carcinoma

et al. 2021

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Background The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence‐free survival. The prognostic model that agreed best with actual outcomes had a C‐index of 0.76. Conclusion Prognostic scoring models may improve individualized follow‐up strategies after curatively intended treatment for patients with parotid gland carcinoma.

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Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome

Cited by 36 publications

References 37 publications

Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy

Survival Outcomes and Prognostic Factors in Salivary Gland Cancers Treated by Surgery and Adjuvant Radiotherapy

Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center

Prognostic scoring models in parotid gland carcinoma

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