Screening of specific aptamers against chlorpromazine and construction of novel ratiometric fluorescent aptasensor based on metal-organic framework

Song, Mingqian; Li, Changxin; Wu, Shijia; Duan, Nuo

doi:10.1016/j.talanta.2022.123850

Cited by 16 publications

(7 citation statements)

References 48 publications

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“…Only one MOF-based PL sensor of chlorpromazine was reported by Duan et al 111 In this study, they synthesized Zr(IV)-MOF under solvothermal conditions. After the MOF synthesis, the pores of the MOF were filled with Rhodamine 6G dye.…”

Section: Artemisinin (Atc)mentioning

confidence: 97%

“…Most often chlorpromazine is used to treat psychotic conditions, including schizoaffective and schizophrenia disorders. It aids in reducing the accompanying hallucinations, delusions, and disordered thinking . Overdosing of chlorpromazine can lead to persistent drug residues in edible tissues which could be dangerous to human health and animal welfare.…”

Section: Fluorescence-driven Sensing Of Various Pharmaceutical Drugs ...mentioning

confidence: 99%

“…It aids in reducing the accompanying hallucinations, delusions, and disordered thinking. 111 Overdosing of chlorpromazine can lead to persistent drug residues in edible tissues which could be dangerous to human health and animal welfare. The European Union has currently issued an order stating that "chlorpromazine shall not be detected in animal-derived food".…”

Section: Artemisinin (Atc)mentioning

confidence: 99%

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Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Ghosh,

Rana,

Biswas

2023

Chem. Mater.

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The surging growth of clinical and pharmaceutical medication as a consequence of population growth has become a threat to the environment. The inherent antagonistic effects of medications and their metabolized side products on a healthy society is an essential concern requiring immediate monitoring. To speculate on these environmental pollutants, a huge number of selective, sensitive, costeffective, and user-compatible metal−organic framework (MOF)-based fluorescent sensors have been reported by many prominent research groups. Many recent review articles cover the details of MOF-based florescence sensing of antibiotics, but an accumulation of MOF-based fluorometric detection of other pharmaceutical drugs is still not reported. Realizing this research gap, we have discussed most of the reported MOF sensors for various pharmaceutical drugs in this Review. The details of selectivity, sensitivity (limit of detection (LOD) and Stern−Volmer constant (K sv )), response time, and proposed mechanisms of drug sensing have been thoroughly discussed. Moreover, this article also covers the details of a few MOF-based antibiotic sensors, which have not been covered by any previous report. Therefore, this Review will provide valuable information and guidance to researchers to develop targeted fluorescent sensors for hazardous pharmaceutical drugs. Additionally, environmental science researchers can leverage this information to enhance their efforts to monitor and control environmental pollution.

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Section: Artemisinin (Atc)mentioning

confidence: 97%

Section: Fluorescence-driven Sensing Of Various Pharmaceutical Drugs ...mentioning

confidence: 99%

Section: Artemisinin (Atc)mentioning

confidence: 99%

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Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Ghosh,

Rana,

Biswas

2023

Chem. Mater.

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“…Thus, it is necessary to develop a sensitive, fast, and accurate detection method for monitoring CPZ levels in the human body. At present, several methods for detecting CPZ have been reported, including fluorescence, 6 chemiluminescence, 7,8 high-performance liquid chromatography, 9 surface-enhanced Raman spectroscopy (SERS), 10 and so on. Although these methods have good sensitivity and selectivity, they require sophisticated instruments and professional technology.…”

Section: Introductionmentioning

confidence: 99%

An electrochemical chlorpromazine sensor based on a gold–copper bimetallic synergetic molecularly imprinted interface on an acupuncture needle electrode

Chen

Liu

Wang

et al. 2023

Analyst

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“…Therefore, rapid and highly sensitive quantitative analysis of CPZ is of great importance. To date, numerous techniques have been developed to realize the determination of CPZ, such as high-performance liquid chromatography [ 4 ], spectrophotometry [ 5 ], capillary electrophoresis [ 6 , 7 ], fluorometry [ 8 ], gas chromatography coupled with mass spectrometry [ 9 ], and electrochemistry [ 10 , 11 ]. Electrochemical sensors have shown the advantages of rapidity, simplicity, high sensitivity, and inexpensiveness and received considerable attention [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Disposable Electrochemical Sensors for Highly Sensitive Detection of Chlorpromazine in Human Whole Blood Based on the Silica Nanochannel Array Modified Screen-Printed Carbon Electrode

et al. 2022

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Rapid and highly sensitive quantitative analysis of chlorpromazine (CPZ) in human whole blood is of great importance for human health. Herein, we utilize the screen-printed carbon electrodes (SPCE) as the electrode substrates for growth of highly electroactive and antifouling nanocomposite materials consisting of vertically ordered mesoporous silica films (VMSF) and electrochemically reduced graphene oxide (ErGO) nanosheets. The preparation of such VMSF/ErGO/SPCE could be performed by using an electrochemical method in a few seconds and the operation is controllable. Inner ErGO layer converted from graphene oxide (GO) in the growth process of VMSF provides oxygen-containing groups and two-dimensional π-conjugated planar structure for stable fabrication of outer VMSF layer. Owing to the π-π enrichment and excellent electrocatalytic abilities of ErGO, electrostatic preconcentration and antifouling capacities of VMSF, and inherent disposable and miniaturized properties of SPCE, the proposed VMSF/ErGO/SPCE sensor could be applied for quantitative determination of CPZ in human whole blood with high accuracy and sensitivity, good stability, and low sample consumption.

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Screening of specific aptamers against chlorpromazine and construction of novel ratiometric fluorescent aptasensor based on metal-organic framework

Cited by 16 publications

References 48 publications

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

An electrochemical chlorpromazine sensor based on a gold–copper bimetallic synergetic molecularly imprinted interface on an acupuncture needle electrode

Disposable Electrochemical Sensors for Highly Sensitive Detection of Chlorpromazine in Human Whole Blood Based on the Silica Nanochannel Array Modified Screen-Printed Carbon Electrode

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