Self-aligned and bundled electrospun fibers prepared from blends of polystyrene (PS) and poly(methyl methacrylate) (PMMA) with a hairy-rod polyphenylene copolymer

Uyar, Tamer; Cianga, Ioan; Cianga, Luminita; Besenbacher, Flemming; Yaǧcı, Yusuf

doi:10.1016/j.matlet.2009.04.039

Cited by 16 publications

(13 citation statements)

References 15 publications

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“…The alignment of the electrospun fibers was observed in both cases, but the alignment of the electrospun fibers including PS was better than that of the electrospun fibers including PMMA. They confirmed that the phenomenon was closely related to the electric properties of the polymers [20]. Figure 6i shows the full width at half maximum (FWHM) values for the various concentrations of SF; increasing the concentration of SF contributes to the alignment of the electrospun biocomposites.…”

Section: Resultssupporting

confidence: 57%

Biocomposites Electrospun with Poly(ε-caprolactone) and Silk Fibroin Powder for Biomedical Applications

Lee

Kim²

2010

Journal of Biomaterials Science, Polymer Edition

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Biomedical synthetic polymers have been used in soft and hard tissue regeneration because of their good processability and biodegradability. However, biomaterials such as poly(ε-caprolactone) (PCL) have various shortcomings, including intrinsic hydrophobicity and lack of bioactive functional groups. The material must be reinforced with natural biomaterials to achieve good cellular and mechanical performance as biomedical material. We fabricated a biocomposite using PCL and silk fibroin (SF) powder, which has good biocompatibility and mechanical properties. The hydrophilicity, mechanical properties and cellular behavior of the PCL/SF fibers were analyzed. In addition, we obtained a highly oriented conduit of electrospun biocomposite fibers by modifying the rolling collector of the electrospinning system. As the alignment of micro/nanofibers increased, the orthotropic mechanical properties were improved. The biocompatibility of the biocomposite was evaluated in a culture of bone-marrow-derived rat mesenchymal stem cells. The cellular result demonstrated the potential usefulness of electrospun biocomposites for various biomedical conduit systems.

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Section: Resultssupporting

confidence: 57%

Biocomposites Electrospun with Poly(ε-caprolactone) and Silk Fibroin Powder for Biomedical Applications

Lee

Kim²

2010

Journal of Biomaterials Science, Polymer Edition

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“…26 The degree of fiber alignment increased with the electrical conductivity of the polymer solution. 27 A quantitative orientation factor, f ¼ (90 À / 0 )/90 was calcu-lated from FWHM (/ 0 ) of the orientation distribution of the PCL/SIS fibers made with various concentrations of SIS. This orientation factors were 0.3, 0.47, 0.54, and 0.56 for PCL, PCL/SIS-I, PCL/SIS-II, and PCL/SIS-IIII, respectively.…”

Section: Resultsmentioning

confidence: 99%

Electrospun micro/nanofibrous conduits composed of poly(ε‐caprolactone) and small intestine submucosa powder for nerve tissue regeneration

Hong

Kim

2010

J Biomed Mater Res

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Three-dimensional biocompatible and biodegradable scaffolds play important roles in tissue engineering. In this study, fibrous mats composed of electrospun poly(epsilon-caprolactone) (PCL)/small intestine submucosa (SIS) tubes were fabricated with a high degree of longitudinal alignment as a conduit for peripheral nerves. Fourier transform infrared analyses of electrospun PCL/SIS mats with various amounts of SIS showed that the SIS was well embedded within the PCL matrix. The diameter of the PCL/SIS fibers with the 3 wt % of SIS in the PCL solution decreased 40% relative to that of pure PCL fibers due to increased electrical conductivity and decreased surface tension. PCL/SIS (3 wt %) electrospun mats exhibited various synergistic effects, including stronger mechanical properties (Young's modulus = more than 80%) and enhanced hydrophilicity (water contact angle at 30 min = 54 degrees ) relative to pure PCL (water contact angle at 30 min = 142 degrees ). Cell attachment and proliferation experiments demonstrated that the interactions between nerve cells (PC-12) and the PCL/SIS conduits were more favorable than those between PC-12 cells and a pure PCL conduit. This study contributes to the understanding of the effects of including SIS in electrospun composite mats. The ability to fabricate highly aligned tubes of PCL/SIS with appropriate mechanical properties and cellular interactions shows great potential for the design of nerve regeneration conduits.

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“…The amphipolar character was previously confirmed by electrospining investigations of the blends of this copolymer with PSt and poly(methyl methacrylate) (PMMA). 81 The selfalignment and bundling characteristics observed for the obtained fibers were ascribed to the unique molecular architecture of this PPP and its peculiar interactions with the solvents and polymer matrix used for electrospinning.…”

Section: ■ Results and Discussionmentioning

confidence: 94%

From Invisible Structures of SWCNTs toward Fluorescent and Targeting Architectures for Cell Imaging

Şeleci

Bongartz

et al. 2013

Biomacromolecules

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Single-walled carbon nanotubes (SWNTs) are unique nanostructures used as cargo systems for variety of diagnostic and therapeutic agents. For taking advantage of these structures in biological processes, they should be visible. Therefore, fluorescence labeling of SWCNTs with various probes is a significant issue. Herein, we demonstrate a simple approach for cell specific imaging and diagnosis by combining SWCNTs with a copolymer poly(para-phenylene) (PPP) containing polystyrene (PSt) and poly(ε-caprolactone) (PCL) side chains (PPP-g-PSt-PCL). In this approach PPP-g-PSt-PCL is noncovalently attached on carboxyl functional SWCNTs. The obtained fluorescent probe is bound to folic acid (FA) for targeted imaging of folate receptor (FR) positive HeLa cells. In vitro studies demonstrate that this conjugate can specifically bind to HeLa cells and indicate great potential for targeting and imaging studies.

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Self-aligned and bundled electrospun fibers prepared from blends of polystyrene (PS) and poly(methyl methacrylate) (PMMA) with a hairy-rod polyphenylene copolymer

Cited by 16 publications

References 15 publications

Biocomposites Electrospun with Poly(ε-caprolactone) and Silk Fibroin Powder for Biomedical Applications

Biocomposites Electrospun with Poly(ε-caprolactone) and Silk Fibroin Powder for Biomedical Applications

Electrospun micro/nanofibrous conduits composed of poly(ε‐caprolactone) and small intestine submucosa powder for nerve tissue regeneration

From Invisible Structures of SWCNTs toward Fluorescent and Targeting Architectures for Cell Imaging

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