Sentinel Node Biopsy as Staging Tool in a Multimodality Treatment Approach to Cancer of the Oral Cavity and the Oropharynx

Abstract

Method promises reduction of elective ND and morbidity in N0 patients.

Sentinel lymph node biopsy in squamous cell carcinomas of the lips and the oral cavity—A single center experience

“…The sensitivity rate is poorer than that found in other studies with surgical staging by SNB [21,47]. In the multicenter study published by Ross et al [21] with 52 patients with T1 and T2 tumors of the oral cavity, only two false negative cases of nodal disease were found in the follow-up and a high rate of true positives resulting in a sensitivity rate of 91%.…”

The effect of intraarterial high-dose cisplatin on lymph nodes in oral and oropharyngeal cancer

“…The rate of occult metastases in 366 patients with cN0 disease presented at The Second International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer was 29% revealed by, and an additional 4% not revealed by sentinel node biopsy. [13] In our department, sentinel node biopsy has been carried out since 2000, [14,15] and the upstaging rate in patients treated with pre-surgical iaCHT with high-dose cisplatin revealed by scintigraphic lymph node mapping and sentinel node biopsy has been 12% due to sentinel nodes, and an additional 4% due to nonsentinel nodes. All patients without further neck treatment remained free of neck metastases to date (mean follow-up: 31.5 months).…”

Le ganglion sentinelle dans les carcinomes épidermoïdes de la tête et du cou

“…Le curage est ré alisé uniquement si le GS montre un envahissement tumoral. En effet, de nombreuses é tudes ont validé la fiabilité de cette technique, qui n'engendre pas plus d'é chec ganglionnaire que l'é videment de principe, aussi bien en termes de contrô le local que de survie [5,[15][16][17][18]25,27,29]. Les patients chez qui aucun traitement chirurgical n'a é té retenu, pourraient aussi bé né ficier de la recherche du GS dans une optique de dé flation thé rapeutique.…”