Silicon nanowires as field-effect transducers for biosensor development: A review

Noor, M. Omair; Krull, Ulrich J.

doi:10.1016/j.aca.2014.03.016

Cited by 117 publications

(73 citation statements)

References 144 publications

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“…[39][40][41] There is also significant interest in the development of carbon-based devices which do not have an oxide layer such as graphene or carbon-nanotube devices. 14,42 The advantage of these devices is stated to be potential sensitivity enhancement via (i) direct contact with analyte (ii) the size of the material being comparable to the size of the analyte. 43 It should be noted that the lack of a band-gap in graphene produces a limitation in the ability of the transistor to transduce a change in surface potential to a change in current response.…”

Section: Operation Of Field-effect Sensorsmentioning

confidence: 99%

“…Third, it is well characterised, widely commercially available and there is an abundance of literature on chemical-functionalisation of biotin to sensor surfaces. 42,72,75 Finally, the isoelectric point ( pI) of streptavidin [76][77][78][79][80] results in a near-neutral protein under physiological conditions, which reduces its propensity for nonspecific binding. Despite these advantages, it should be noted that the unusually high affinity of streptavidin for biotin makes it unrepresentative of binding characteristics of most biomolecules.…”

Section: Streptavidin Biochemistrymentioning

confidence: 99%

See 1 more Smart Citation

Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Lowe

Sun

Zeimpekis

et al. 2017

Analyst

135

107

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a Field-Effect Transistor sensors (FET-sensors) have been receiving increasing attention for biomolecular sensing over the last two decades due to their potential for ultra-high sensitivity sensing, label-free operation, cost reduction and miniaturisation. Whilst the commercial application of FET-sensors in pH sensing has been realised, their commercial application in biomolecular sensing (termed BioFETs) is hindered by poor understanding of how to optimise device design for highly reproducible operation and high sensitivity. In part, these problems stem from the highly interdisciplinary nature of the problems encountered in this field, in which knowledge of biomolecular-binding kinetics, surface chemistry, electrical double layer physics and electrical engineering is required. In this work, a quantitative analysis and critical review has been performed comparing literature FET-sensor data for pH-sensing with data for sensing of biomolecular streptavidin binding to surface-bound biotin systems. The aim is to provide the first systematic, quantitative comparison of BioFET results for a single biomolecular analyte, specifically streptavidin, which is the most commonly used model protein in biosensing experiments, and often used as an initial proofof-concept for new biosensor designs. This novel quantitative and comparative analysis of the surface potential behaviour of a range of devices demonstrated a strong contrast between the trends observed in pH-sensing and those in biomolecule-sensing. Potential explanations are discussed in detail and surfacechemistry optimisation is shown to be a vital component in sensitivity-enhancement. Factors which can influence the response, yet which have not always been fully appreciated, are explored and practical suggestions are provided on how to improve experimental design.

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Section: Operation Of Field-effect Sensorsmentioning

confidence: 99%

Section: Streptavidin Biochemistrymentioning

confidence: 99%

Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Lowe

Sun

Zeimpekis

et al. 2017

Analyst

135

107

View full text Add to dashboard Cite

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“…SiNW are attractive materials in FET-based biosensors design due to their high surface-to-volume ratio, which enables the sensors ultrasensitive detection capability [95,96]. SiNW FET-based biosensors were firstly reported in 2011 by Cui et al [97].…”

Section: Trends In Fet-based Immunosensors Using Nanomaterials As Senmentioning

confidence: 99%

Recent Trends in Field-Effect Transistors-Based Immunosensors

Moraes

Kubota

2016

Chemosensors

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Abstract:Immunosensors are analytical platforms that detect specific antigen-antibody interactions and play an important role in a wide range of applications in biomedical clinical diagnosis, food safety, and monitoring contaminants in the environment. Field-effect transistors (FET) immunosensors have been developed as promising alternatives to conventional immunoassays, which require complicated processes and long-time data acquisition. The electrical signal of FET-based immunosensors is generated as a result of the antigen-antibody conjugation. FET biosensors present real-time and rapid response, require small sample volume, and exhibit higher sensitivity and selectivity. This review brings an overview on the recent literature of FET-based immunosensors, highlighting a diversity of nanomaterials modified with specific receptors as immunosensing platforms for the ultrasensitive detection of various biomolecules.

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“…The integration of silicon nanowire (SiNW) as electrical field-based sensors has been demonstrated as ultra-sensitive devices for label-free biomolecular detection [1]. However, the mass production of SiNW devices remains an ongoing challenge due to not only expensive technology but also lack of reproducibility in electrical properties from one NW device to another.…”

Section: Introductionmentioning

confidence: 99%

On the Development of Label-Free DNA Sensor Using Silicon Nanonet Field-Effect Transistors

Nguyen

Legallais

Morisot

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Abstract:In this paper, the process and electrical characteristics of DNA sensor devices based on silicon nanonet (SiNN) field-effect transistors are reported. The SiNN, another name of randomly oriented Si nanowires network, was successfully integrated into transistor as p-type channel using standard microelectronic technology. The SiNN-based transistors exhibit a high initial ON-state current (5.10 −8 A) and homogeneous electrical characteristics. For DNA detection, a new and eco-friendly functionalization process based on glycidyloxypropyltrimethoxysilane (GOPS) was performed which enables the covalent grafting of DNA probes on SiNN. This hybridization leads to a significant decrease of ON-state current of device. Additionally, it is observed that SiNN devices reveal reproductive current response to DNA detection. We demonstrate, for the first time, the successful integration of SiNN into sensor for electrical label-free DNA detection at low cost.

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Silicon nanowires as field-effect transducers for biosensor development: A review

Cited by 117 publications

References 144 publications

Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Recent Trends in Field-Effect Transistors-Based Immunosensors

On the Development of Label-Free DNA Sensor Using Silicon Nanonet Field-Effect Transistors

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