Simultaneous determination of amoxycillin and clavulanic acid in pharmaceutical products by HPLC with β-cyclodextrin stationary phase

Simultaneous determination of amoxicillin and ranitidine in rat plasma by high-performance liquid chromatography

“…The analytical methods reported for the quantification of amoxicillin include spectrophotometry [7,8], capillary electrophoresis [9,10] and liquid chromatography (LC); detection methods include amperometry [11], fluorometry [12], mass spectrometry [13,14] and UV [15][16][17][18][19][20].…”

Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC–ESI mass spectrometry

“…Early HPLC methods involved pretreatment of amoxicillin and clavulanic acid with imidazoale [6], precolumn [7] and postcolumn derivatization [8] or ion-pairing [9]. Later HPLC methods using reversed-phase or ␤-cyclodextrin with ultraviolet (UV) or amperometric detection [10][11][12][13][14][15][16] have been developed. Capillary electrophoresis (CE) with UV detection was also used for a simultaneous determination of amoxicillin and clavulanic acid in a pharmaceutical formulation [17].…”

A liquid chromatographic method for simultaneous determination of amoxicillin sodium and sulbactam sodium in a combination formulation

“…The methods available for the determination of amoxicillin sodium include spectrophotometry [5,6], capillary electrophoresis [7,8] and liquid chromatography (LC) with different ways of detection such as amperometry [9], fluorometry [10], mass spectrometry [11,13] and UV [12,[14][15][16][17][18]23]. The methods published for the determination of sulbactam sodium are LC [19][20][21], enzymatic method [22] and spectrophotometry [24].…”

“…The methods published for the determination of sulbactam sodium are LC [19][20][21], enzymatic method [22] and spectrophotometry [24]. Most of the LC methods with UV detection were used for the individual determination of the two drugs in biological samples and complex chromatographic conditions were involved such as chiral stationary phase [12], on-line postcolumn [13] or precolumn [21] derivatisation, column switching [14] or coupled column [15], paired-ion aqueous mobile phase [16][17][18] and gradient elution [17,18]. Two and sulbactam sodium in pharmaceutical preparations [25,26].…”