PurposeThis study aimed to assess the fracture resistance of monolithic zirconia‐reinforced lithium silicate laminate veneers (LVs) fabricated on various incisal preparation designs.Materials and methodsSixty maxillary central incisors with various preparation designs were 3D‐printed, 15 each, including preparation for: (1) LV with feathered‐edge design; (2) LV with butt‐joint design; (3) LV with palatal chamfer; and (4) full‐coverage crown. Restorations were then designed and manufactured from zirconia‐reinforced lithium silicate (ZLS) following the contour of a pre‐operation scan. Restorations were bonded to the assigned preparation using resin cement and following the manufacturer's instructions. Specimens were then subjected to 10,000 thermocycles at 5 to 55°C with a dwell time of 30 s. The fracture strength of specimens was then assessed using a universal testing machine at a crosshead speed of 1.0 mm/min. One‐way ANOVA and Bonferroni correction multiple comparisons were used to assess the fracture strength differences between the test groups (α = 0.001). Descriptive fractographic analysis of specimens was carried out with scanning electron microscopy images.ResultsComplete coverage crown and LV with palatal chamfer design had the highest fracture resistance values (781.4 ± 151.4 and 618.2 ± 112.6 N, respectively). Single crown and LV with palatal chamfer had no significant difference in fracture strength (p > 05). LV with feathered‐edge and butt‐joint designs provided significantly (p < 05) lower fracture resistance than complete coverage crown and LV with palatal chamfer design.ConclusionThe fracture resistance of chairside milled ZLS veneers was significantly influenced by the incisal preparation designs tested. Within the limitation of this study, when excessive occlusal forces are expected, LV with palatal chamfer display is the most conservative method of fabricating an indirect restoration.