Stability-Indicating Assay for Hydrochlorothiazide

Daniels, Stephanie L.; Vanderwielenx, A.J.

doi:10.1002/jps.2600700225

Cited by 20 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several high-performance liquid chromatography methods have been developed for measuring hydrochlorothiazide concentration in pharmaceutical preparations (European Pharmacopoeia, 2002;Daniels and Vanderwielen, 1981;Stewart and Clark, 1986;Kartal and Erk, 1999;Zecevic et al, 2000;Hertzog et al, 2002;Jonczyk and Nowakowska, 2001).…”

Section: Introductionmentioning

confidence: 99%

Development of solid‐phase extraction method and its application for determination of hydrochlorothiazide in human plasma using HPLC

Zendelovska

Stafilov

Milosevski

2004

Biomedical Chromatography

View full text Add to dashboard Cite

A high-performance liquid chromatographic method was developed, validated and applied for the determination of hydrochlorothiazide in human plasma. The effects of mobile phase composition, buffer concentration, mobile phase pH and concentration of organic modifiers on retention of hydrochlorothiazide and internal standard were investigated. The method involves solid-phase extraction on RP-select B cartridges followed by isocratic reversed-phase chromatography on a Hibar Lichrospher 100 RP-8 column with UV detection at 230 nm. The recovery, selectivity, linearity, precision and accuracy of the method were evaluated from spiked human plasma samples. Limit of quantification was 10 ng mL(-1). The method has been implemented to monitor hydrochlorothiazide levels in patient samples.

show abstract

Section: Introductionmentioning

confidence: 99%

Development of solid‐phase extraction method and its application for determination of hydrochlorothiazide in human plasma using HPLC

Zendelovska

Stafilov

Milosevski

2004

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…Various analytical methods such as HPLC [9][10][11][12], differential pulse voltameter [13], stability indicating determination [14], photometric determination of HCTZ [15] were reported. BF is official in USP [16], whereas HCTZ is official in USP, IP [17] and BP [18].…”

Section: Bisoprolol Fumarate (Bf) (+/-) -1-(4-((2-(-methyl Ethoxy) Ementioning

confidence: 99%

Development and Validation of TLC-Densitometry Method for Simultaneous Estimation of Bisoprolol Fumarate and Hydrochlorothiazide in Bulk and Tablets

Bhoya¹

2012

J Chromat Separation Techniq

View full text Add to dashboard Cite

A new simple, precise, accurate and selective TLC-densitometry method has been developed for simultaneous determination of bisoprolol fumarate and hydrochlorothiazide in tablet dosage form. Chromatographic separation was performed on aluminum plate precoated with silica gel 60F254, using chloroform: ethanol: glacial acetic acid fumarate and hydrochlorothiazide were 0.62 and 0.40, respectively. The reliability of the method was assessed by evaluation of linearity which was found to be 200-1200 ng/spot for bisoprolol fumarate and 100-800 ng/spot for hydrochlorothiazide. Accuracy of the method was accessed by % recovery and found to be 100.02 ± 1.14% for bisoprolol fumarate and 99.91 ± 0.96% for hydrochlorothiazide. The method can be used for routine analysis of bisoprolol fumarate and hydrochlorothiazide in tablet dosage form.

show abstract

“…However, an additional unknown degradate was detected after 16 h in either 0.1 N HCl or 0.1 N NaOH solution. 5 Thomas et al 6 reported analysis of bulk HCTZ by micellar electrokinetic capillary chromatography, and found three unknown peaks, which were not identi®ed in their work.…”

Section: Introductionmentioning

confidence: 97%

“…Deppeler 4 found that solid forms of HCTZ could be stored at ambient temperature for 5 years without evidence of degradation. Stress testing of HCTZ, 5 either 3 months at room temperature (10 mg HCTZ/mL methanol) or 4 days at 1008C (dry powder HCTZ), yielded only the degradate DSA. However, an additional unknown degradate was detected after 16 h in either 0.1 N HCl or 0.1 N NaOH solution.…”

Section: Introductionmentioning

confidence: 99%