Structure, swelling, and drug release of thermoresponsive poly(amidoamine) dendrimer–poly(N-isopropylacrylamide) hydrogels

Incorporation of Fe@Au nanoparticles into multiresponsive pNIPAM-AAc colloidal gels modulates drug uptake and release

“…[10] The transition usually happens over a temperature range instead of a single temperature owing to different crystalline and amorphous domains in the polymer, branching and side-chains, molecular weight distributions among other factors. [11] However, this temperature driven transition allows for release of cargo molecule at a desired rate by fine tuning the physico-chemical properties of the NGs.…”

Triggering Mechanisms of Thermosensitive Nanoparticles Under Hyperthermia Condition

“…The insufficient mechanical stability of polymeric nanocarriers under load‐bearing conditions is another limitation that may impede their clinical application. These materials could undergo deterioration during peristaltic movements in the gastrointestinal tractus, or because of exposure to the interstitial or intramuscular shear forces . Therefore, clinical application of these nanocarriers requires long‐term cytotoxicity investigation and sufficient control of their phase transition temperature range, mechanical strength, collapse intensity, and surface properties …”

A robust method to calculate the volume phase transition temperature (VPTT) for hydrogels and hybrids

“…Systems undergoing phase change have a myriad of applications that range from drug delivery, [1][2][3][4][5][6] membrane separation, [7][8][9][10] ow control, 11,12 and bio-sensing [13][14][15] among others. In order to exploit the material properties of such systems, it is important to denitively characterize the phase transition that happens above the lower critical solution temperature (LCST) of the polymer.…”

“…18 While the LCST or VPTT is dened as a single temperature from a thermodynamic standpoint, real systems undergo phase transition over a range of temperatures owing to inherent polydispersity stemming from different chain lengths, branching, crystallinity and so on. 2 A common method to estimate this transition temperature is to measure a spectroscopic parameter like optical density, turbidity, absorbance or size or specic heat as a function of temperature and assign the transition temperature at the average of the sigmoidal plot of the curve or at the mid-point of the range. [19][20][21][22][23] There exists no study to our knowledge where VPTT of such phase changing systems have been exhaustively calculated using a well-dened method with experimental data from both heating and cooling cycles.…”