Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P‐AbPS)

Abstract

Ihe synthesis of phosphorylated AchynmUres bidentota pdysaccbaride (P-AbPS) wss reported based on Merent strategies.obtained when phosphorus oxycbloride (PO(&) was used as a phosphorylating agent and trimethyl phosphate-pyridine or dimethyl formamide wss used as solvent. The hhences of different solvents and d o n conditions were discussed . The pharmmlogv assay shorn that P-AhPS postses antitumor activity against sarcoma 180 and Lewis lung cancer in mice. The P-AbFS With l&h d m of s u b s t i w o n (D.S. > 0.5) WBS

Preparation, chain conformation and anti-tumor activities of water-soluble phosphated (1→3)-α-d-glucan from Poria cocos mycelia

“…It has been reported that phosphated polysaccharides exhibited anti-inflammatory, anti-tumor or anti-viral activities, especially immunomodulatory (Chen, Zhang, & Tian, 2002;Lyuksutova et al, 2005;Williams et al, 2004). Specifically, the phosphorylated Achyranthes bidentata polysaccharide with high degree of substitution was obtained when phosphorus oxychloride was used as phosphorylating agent, and it possessed anti-tumor activities against Sarcoma 180 and Lewis lung cancer in mice (Chen et al, 2002).…”

“…Specifically, the phosphorylated Achyranthes bidentata polysaccharide with high degree of substitution was obtained when phosphorus oxychloride was used as phosphorylating agent, and it possessed anti-tumor activities against Sarcoma 180 and Lewis lung cancer in mice (Chen et al, 2002). Williams et al have successfully prepared water-soluble glucan phosphate which was derived from water-insoluble (1 → 3)-␤-d-glucan in Saccharomyces cerevisiae (Williams et al, 1991).…”

Preparation of Water Soluble Yeast Glucan by Four Kinds of Solubilizing Processes

“…Numerous studies have therefore focused on converting these glucans into a water-soluble form through chemical modification such as amination [13], sulfation [14] and phosphorylation [15]. It has also been demonstrated that such modified polysaccharides exhibit anti-inflammatory, anti-tumor, anti-viral and immunomodulatory activities [16][17][18].…”

Preparation and application of phosphorylated Lotus root polysaccharide

“…Polysaccharide derivatives have antitumor activity. Phosphorylated Achyranthes bidentata polysaccharide (P-ABPS) showed antisarcoma activity in a mouse model of Lewis lung cancer (Chen et al, 2002;Huang & Huang., 2017). activity (Qi et al, 2005;Shao et al, 2013;Suzuki & Terasawa, 2020;Wei et al, 2012).…”