Study of extended spectrum β-lactamase producing Enterobacteriaceae and antibiotic coresistance in a tertiary care teaching hospital

Shashwati, Nema; Kiran, Tripathi; Dhanvijay, Ashok Kumar

doi:10.4103/0976-9668.127280

Cited by 55 publications

(66 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be attributed to the association of multi drug resistance in ESBL producing isolates as they carry co-resistance genes for other non -β-lactam antibiotics and thus limiting the therapeutic options [10]. The ESBL detection in our study was 47.4% which was in concordance with other studies [11][12][13]. ESBL production was highest in E.coli isolates (53.08%) followed by K.pneumoniae 27 (50%) which was similar to studies done by Shiju, et al, and Linda, et al [9,14] 33.33% of the Pseudomonas spp.…”

Section: Fig-1 Phenotypic Confirmatory Disc Diffusion Test Discussionsupporting

confidence: 82%

Study on Phenotypic Detection of Esbl in Gram Negative Bacterial Isolates in a Tertiary Care Hospital in Bangalore

Sangeetha¹,

Hittinahalli²,

Lyra³

2018

BIOP

View full text Add to dashboard Cite

Section: Fig-1 Phenotypic Confirmatory Disc Diffusion Test Discussionsupporting

confidence: 82%

Study on Phenotypic Detection of Esbl in Gram Negative Bacterial Isolates in a Tertiary Care Hospital in Bangalore

Sangeetha¹,

Hittinahalli²,

Lyra³

2018

BIOP

View full text Add to dashboard Cite

“…Similar pattern of Klebsiella spp. ESBL producer also noticed accounting to 45.0%, which is somewhat similar to that found in the study from parts of India and Iran [11, 29], but were comparatively lesser than reported from Rajasthan, 67.0% [30]. Our finding of higher ESBL producers among E.coli , is in conformity with some of the previous studies [11,13].…”

Section: Discussionsupporting

confidence: 91%

“…Klebsiella spp. and E. coli were reported as the most common Enterobacteriaceae isolates, similar to earlier findings [11, 12, 13]. However, the distribution is not in concordance to those observed earlier, in our case Klebsiella spp.…”

Section: Discussionsupporting

confidence: 75%

See 1 more Smart Citation

Menace to the ultimate antimicrobials among commonEnterobacteriaceaeclinical isolates in part of North-East India

Sharma

Chetia

Puzari

et al. 2019

Preprint

View full text Add to dashboard Cite

8 Introduction 9Enterobacteriaceae, the normal dwellers in the human intestine, commonly associated with a 10 variety of community acquired and nosocomial infections. Emerging trend of antibiotic 11 resistance among these strains is a notable issue globally; more serious threat is the resistance 12 against the available last resort antibiotics-the carbapenems. Our study thus intended to 13 determine the burden of resistance towards this ultimate antimicrobial class, so as to assist in the 14 empiric therapeutic decision making process and to search for alternate options. 15 Materials and Methods 16Our study was a cross-sectional study with inclusion of clinical isolates collected from varied 17 sources, from health settings in upper Assam. The isolates were identified based on standard 18 methods of morphology study and biochemical tests. The identified isolates were then subjected 19 to antibiotic susceptibility testing following Kirby-Bauer disc diffusion method and the result 20 interpreted as per the CLSI guidelines. The resistance of the reported carbapenem resistant 2 21 isolates was confirmed by minimum inhibitory concentration (MIC) determination using 22 commercial E-strip kit. 23 Results 24Among the enterobacterial isolates Klebsiella spp. accounted the majority, followed by 25 Escherichia coli, Citrobacter spp., Shigella spp. and others. Multi-drug resistance (MDR) was 26 noted among 67.6% isolates; however, carbapenem resistance was confirmed in 18.9% of the 27 total Enterobacteriaceae isolates. 28 Conclusion 29 Higher prevalence of resistance towards the last resort antimicrobial, carbapenems, among the 30 Enterbacteriaceae isolates of upper Assam seems to be upcoming threat to the region, limiting 31 the treatment options in future. 32 33 37 Resistance towards different classes of existing antibiotics, among the members of 38 Enterobacteriaceae, is an alarming issue worldwide [3]. Carbapenems are a powerful group of 39 broad spectrum beta-lactam antibiotics which, in many cases are our last effective defense 40 against multi-drug resistant (MDR) and extended spectrum beta-lactamase (ESBL) bacterial 41 infections [4, 5]. Increased use and misuse of most of the beta-lactam antibiotics and 3 42 carbapenems, resulted in the emergence of Carbapenem-resistant Enterobacteriaceae (CRE) 43 with worldwide presence [2, 6, 7]. 44 CRE have been associated with high mortality and morbidity rates of up to 40-50% reported in 45 some studies [8]. Several studies on CRE had been conducted in India from time to time; 46 however, there are limited reports on the prevalence and distribution of CRE from the North-47 East region. A study from Manipur reported 30% of the Gram-negative isolates obtained from a 48 tertiary care hospital were resistant towards carbapenem [9]. 49 Our study thus aimed to bridge the gap of the prevalence data on carbapenem resistance among 50 the Enterobacteriaceae isolates obtained from different health settings of upper Assam. 51 Methods 52 The study was a cross-sectional laboratory based stud...

show abstract

“…Endemic transmission of ESBL-producers can be controlled by appropriate infection control measures and prudent antibiotic management interventions [4]. Reliable detection of ESBL-producers by clinical microbiology laboratory is essential to provide appropriate therapy and to control nosocomial outbreaks [9,10].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and Genotypic Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumonia isolates from Patient’s Urine specimens

Alfola¹,

Kamel²,

Nada³

et al. 2016

int. arab. j antimicrob. agents

View full text Add to dashboard Cite

Introduction: Extended-spectrum β-lactamases (ESBLs)-producing Enterobacteriaceae are a clinical threat that may cause nosocomial as well as community-acquired infections. E.coli and Klebsiella pneumoniae are among the most common Gram-negative bacilli causing urinary tract infections. This study investigated certain molecular characteristics of phenotypically proved ESBL-producing E. coli and K. pneumoniae.

show abstract

Study of extended spectrum β-lactamase producing Enterobacteriaceae and antibiotic coresistance in a tertiary care teaching hospital

Cited by 55 publications

References 24 publications

Study on Phenotypic Detection of Esbl in Gram Negative Bacterial Isolates in a Tertiary Care Hospital in Bangalore

Study on Phenotypic Detection of Esbl in Gram Negative Bacterial Isolates in a Tertiary Care Hospital in Bangalore

Menace to the ultimate antimicrobials among commonEnterobacteriaceaeclinical isolates in part of North-East India

Phenotypic and Genotypic Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumonia isolates from Patient’s Urine specimens

Contact Info

Product

Resources

About