Synthesis, Characterisation and Electrochemical studies of Transition Metal complexes with bis-(macro-cyclic) Ligands

Vardhan, Vipul; Sharma, T.R.

doi:10.13005/ojc/280263

Cited by 3 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results clearly indicate a better hypoglycemic activity of Nd-glimepiride complex over its parent drug. [43][44][45][46]…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Synthesis, Characterization and Antidiabetic Study of Nd (III) Complex of 1-(p-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)Ethyl) Phenyl)Sulfonyl)-3-(trans-4-methyl Cyclohexyl) Urea Amaryl or Glimepiride, An Oral Antidiabetic Drug

Jose¹,

Iqbal²

2013

Biomed. Pharmacol. J.

View full text Add to dashboard Cite

This paper deals with the synthesis and characterization of a glimepiride-neodymium complex, rare earth's metal. Glimepiride is an oral hypoglycemic agent. The conductometric titrations were conducted using monovariation method which shows the ligand metal ratio as 2:1. Molar conductance value indicate that complex is non-ionic in nature. Analytical results agree to the molecular formula (C 24 H 34 N 4 O 5 S) 2 Nd.4H 2 O. rare earth's element Nd shows the high coordination sites. The structure of the complex was assigned as hexagonal in which ligand moleculas joining the central Nd(III) atom with nH 2 O molecules. Infrared spectral studies have supported coordination of sulphonyl oxygen on one side and enolic oxygen attached from other side and four water molecule attached by four coordination sides with the neodymium ion. Mass spectral, thermal and magnetic studies supports structure of the complex proposed on the basis of analytical data X-ray diffraction studies.

show abstract

“…These results clearly indicate a better hypoglycemic activity of Nd-glimepiride complex over its parent drug. [43][44][45][46]…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Synthesis, Characterization and Antidiabetic Study of Nd (III) Complex of 1-(p-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)Ethyl) Phenyl)Sulfonyl)-3-(trans-4-methyl Cyclohexyl) Urea Amaryl or Glimepiride, An Oral Antidiabetic Drug

Jose¹,

Iqbal²

2013

Biomed. Pharmacol. J.

View full text Add to dashboard Cite

show abstract

“…Pmdpt was prepared as previously described 13 . The reaction of crude N-(4-methyl phenyl) pyridine-2-carboxyimidothioate (5.13 g/cm 3…”

Section: Preparation Of 4-(4-methylphenyl)-35-di(2pyridyl)-4h-124-mentioning

confidence: 99%

“…A solution of [Ru (bipy) 2 Cl 2 ]2H 2 O (0.2 g/ cm 3 , 1mmol/L) in ethanol (20 mL) was boiled for 10 min. and filtered into a solution of adpt (3.0 mg/cm 3 ) or pydpt (0.5 g/cm 3 , 1 mmol/L) or pmdpt (0.35 g/ cm 3 , 1 mmol/L) in ethanol (20 mL), the mixture was reflux for 5 h., and allowed to cool slowly to room temperature.…”

Section: Preparation Of Mono-nuclear Ru (Ii) Complexesmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, Specrtoscopic, Electrochemical and Antibacterial Activities of Mono- and Homobi-nuclear of Ru(II) Complexes with a Triazolate Bridging Ligand

El-Gahami¹,

Albishri²

2013

Orientjchem.

View full text Add to dashboard Cite

Substituted 1,2,4-triazoles has been actively studied as bridging ligands between metal (II) ions coordinating through their N1 and N2 atoms, since their complexes have interesting structures and specific magnetic properties 1-3. Interesting to note that some complexes containing substituted 1,2,4triazole ligands have the spin-crossover properties, which could be used as molecular-based memory devices, displays and optical switches 4-5 .

show abstract

“…The observed electronic spectral bands of the glimepiride ligand and metal complex (copperglimepiride) are given in table 7as follows :- The electronic spectra of the Cu(II) complex of glimepiride shows an absorption bands at 25490 cm -1 and 20533 cm -1 attributed to the LMCT (ligand to metal charge transfer) and 2 Big g 2 A 1 g transition which is compatible with this complex having an square planar structure around the Cu(II) metal ion. [27][28][29][30]…”

Section: Electronic Spectral Studies Of the Complexmentioning

confidence: 99%

Physico-Chemical and Various Spectral Investigations of Copper (II) Complex of Glimepiride, An Oral Active and Highly Potent Antidiabetic Agent

Jose¹,

Mitu²

2013

Biosci., Biotechnol. Res. Asia

View full text Add to dashboard Cite

The synthesis and characterization of a copper complex with glimepiride (an oral antidiabetic drug) has been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of ML 2 type.Analytical data agrees with the molecular formula (C 24 H 34 N 4 O 5 S) 2 Cu. Structure of the complex was assigned as square planar in which ligand molecules lies horizontally joining the central copper atom. Infrared, Mass spectral and particle size analysis had confirm the coordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. The structure for complex was proposed on the basis of analytical data and elemental analysis.

show abstract

Synthesis, Characterisation and Electrochemical studies of Transition Metal complexes with bis-(macro-cyclic) Ligands

Cited by 3 publications

References 4 publications

Synthesis, Characterization and Antidiabetic Study of Nd (III) Complex of 1-(p-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)Ethyl) Phenyl)Sulfonyl)-3-(trans-4-methyl Cyclohexyl) Urea Amaryl or Glimepiride, An Oral Antidiabetic Drug

Synthesis, Characterization and Antidiabetic Study of Nd (III) Complex of 1-(p-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)Ethyl) Phenyl)Sulfonyl)-3-(trans-4-methyl Cyclohexyl) Urea Amaryl or Glimepiride, An Oral Antidiabetic Drug

Synthesis, Specrtoscopic, Electrochemical and Antibacterial Activities of Mono- and Homobi-nuclear of Ru(II) Complexes with a Triazolate Bridging Ligand

Physico-Chemical and Various Spectral Investigations of Copper (II) Complex of Glimepiride, An Oral Active and Highly Potent Antidiabetic Agent

Contact Info

Product

Resources

About