Synthesis of 2-(Substituted Anilino) 4-(Substituted Phenyl)thiazoles

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

“…SKI-II (13) was prepared by condensing 2-bromoketone (11) with thiourea 12 following a literature method [36]. In contrast to SKI-I, SKI-II reacted efficiently with 2-acetoxybenzoyl chloride in the presence of triethylamine to yield the desired product SKI-II-Asp (14).…”