Synthesis of Click‐Chelator via Cu(I)‐Catalyzed Alkyne‐Azide Cycloaddition

Abstract

The click-ligands based on 1,2,3-triazole and pyridine unit has been synthesized via Cu(I)-catalyzed alkyneazide cycloaddition from corresponding organic azides and terminal alkynes. The ligand structure was characterized by NMR, IR and elemental analysis as well as single crystal diffractions. The single crystal structure of the complexes from two different ligands coordinating to Cu(II) and Co(II) ions indicated that the N(2) atom in 1,2,3-triazole unit can act as an efficient donor to metals through the rational molecular design.

Efficient and straightforward click synthesis of structurally related dendritic triazoles

“…9 In organometallics chemistry, N(2) and N(3) of the triazole can coordinate with different metals when the macromolecules contain some spatially closed triazole rings. 10 Many new materials have been successfully obtained by CuAAC, but the most intriguingly aspect is the nature and the function of the 1,2,3-triazole structure within the resulting material properties. This aromatic ring oen affects the properties of the molecules to which it belongs.…”

A linear Cu (II) coordination polymer based on a simple click chelator

“…Since then click chelators have been employed in many fields such as sensors, bio-conjugates, anticancer complexes, catalysts or fluorescent materials [12]. However, most of the research is only focused on the construction of small complexes based on click chelators [12], and few coordination polymers from it have been found until now.Most recently, a simple "click chelator", 2-[(4-Phenyl-5 H-1, 2, 3-triazole) methyl] pyridine) (L, shown in Scheme 1) has been independently synthesized by our group and some other groups [13][14][15][16]. And its coordination chemistry with a series of transition metals has been detailed studied.…”

“…Most recently, a simple "click chelator", 2-[(4-Phenyl-5 H-1, 2, 3-triazole) methyl] pyridine) (L, shown in Scheme 1) has been independently synthesized by our group and some other groups [13][14][15][16]. And its coordination chemistry with a series of transition metals has been detailed studied.…”

“…Thus, utilizing L to compose polymeric structure is still worthy to try. Based on our previous works [13,14], and considering that azido group can adopt the end-on (μ-1, 1-N 3 ) or end-to-end (μ-1, 3-N 3 ) bridging mode to create the polymeric complexes with interesting structures and exotic magnetic properties [5,[17][18][19], we select L as a chelator and azide anion as co-ligand to coordinate with Cu(II) cation, and wish to obtain the coordination polymer with interesting magnetic property. In this work we present a successful example, a linear Cu(II) coordination polymer through the coordination of the simple click chelator L and azido anions with Cu(II) chloride.…”

“…And its coordination chemistry with a series of transition metals has been detailed studied. Different types of complexes have been obtained, but all of them are small molecules [13][14][15][16]. Thus, utilizing L to compose polymeric structure is still worthy to try.…”