Taq1B Polymorphism of Cholesteryl Ester Transfer Protein (CETP) and Its Effects on the Serum Lipid Levels in Metabolic Syndrome Patients

Maroufi, Nazila Fathi; Farzaneh, Khadijeh; Alibabrdel, Mahdi; Zarei, Leila; Cheraghi, Omid; Soltani, Sina; Montazersaheb, Soheila; Akbarzadeh, Maryam; Nouri, Mohammad

doi:10.1007/s10528-016-9766-5

Cited by 18 publications

(8 citation statements)

References 29 publications

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“…This is consistent with Anton et al [36] who hold that the risk of MS was reduced by 32% ( p = 0.005, OR = 0.68) in carriers of the B 2 variant. However, this was different from observations by Jeenduang [38] and Maroufi [39]. …”

Section: Discussioncontrasting

confidence: 99%

Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

Hou

Guo

et al. 2017

IJERPH

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Objective: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the CETP gene polymorphisms and each component of MS. Methods: A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected CETP polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method. Results: (1) Significant differences were found involving the frequency distribution of genotypes and alleles of rs1800775, rs3764261, rs12149545, rs711752, and rs708272 between the control and MS groups (all p < 0.05). (2) rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms were significantly related to the risk of MS (all p < 0.05). (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all p < 0.05). (4) Complete linkage disequilibrium (LD) was identified for two pairs of single nucleotide polymorphisms (SNPs) (rs3764261 and rs12149545 (D’ = 1.000, r2 = 0.931), rs711752 and rs708272 (D’ = 1.000, r2 = 0.996)). (5) The A-G-G-G-C (p = 0.013, odds ratio [OR] = 0.622, 95% confidence interval [95% CI] = 0.427–0.906) and A-T-A-A-T (p < 0.001, OR = 0.519, 95% CI = 0.386–0.697) haplotypes were more frequent in the control group than in the case group. Conclusions: The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of CETP were associated with MS and its components among the Uyghur ethnic group. Complete LD was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). The A-G-G-G-C and A-T-A-A-T haplotypes might be protective factors for MS.

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Section: Discussioncontrasting

confidence: 99%

Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

Hou

Guo

et al. 2017

IJERPH

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“…Multivariate analysis the relationship remained significant (OR = 2.82 [95% CI 1.07-7.41], p = 0.036), despite the relationship rs1800775 polymorphism between cases (MS obese) and non-MS obese is not significant. A study of Maroufi et al found that CETP levels were significantly higher in the adult MS group (1.64 ± 0.32 µg/mL) than healthy controls (1.53 ± 0.34 µg/mL) [23]. In this study, CETP levels in MS obese groups and non-MS obese (2.49 ± 1.03 µg/mL vs. 2.04 ± 0.92 µg/mL) were higher than the previous studies.…”

Section: Discussionmentioning

confidence: 94%

High Level of Serum Cholesteryl Ester Transfer Protein and Chemerin as a Risk Factor of Metabolic Syndrome in Adolescent Obese and the Description of Cholesteryl Ester Transfer Protein −629c/A Gene Promoter Polymorphism

Arimbawa

Suastika

Junitha

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: The prevalence of metabolic syndrome (MS) in children and adolescents has increased, along with increasing incidence of obesity. AIM: The aim of this study was to find out the polymorphism characteristic of cholesteryl ester transfer protein (CETP) -629C/A gene promoter and to prove that the CETP -629C/A polymorphism, serum CETP, and chemerin levels were risk factors of MS in obese adolescents. MATERIALS AND METHODS: A matched case–control study with obese adolescent aged 11–18 years was conducted from May to December 2017. Samples were consecutively recruited in seven junior and senior high schools in Denpasar. Case groups were obese adolescents with MS and control groups were obese adolescents without MS (non-MS obese). Both groups fulfilled eligibility criteria were matched by gender and puberty status. The study data were analyzed by Chi-square test and logistic regression with significant level p < 0.05. RESULTS: Analysis of CETP -629C/A polymorphism showed, AA and CA genotype were not a risk factors for MS when compared with CC genotype (OR = 0.81 [95% CI 0.23–2.88], p = 0.75 and OR = 0.95 [95% CI 0.38–2.37] p = 0.91, respectively). There was no significant difference between individual carriers A allele with individual carriers C allele to risk of MS (OR = 0.91 [95% CI 0.39–2.14], p = 0.83). The cutoff point of CETP levels was ≥2 μg/mL considered as CETP high levels, and <2 μg/mL considered normal; chemerin levels ≥170 ηg/mL considered as chemerin high levels, and <170 ηg/mL considered as normal. High levels of serum CETP were a risk factor in MS compared to normal levels (OR = 2.82 [95% CI 1.07–7.41], p = 0.036) and high levels of serum chemerin were a risk factor in MS compared to normal level (OR = 2.77 [95% CI 1.04–7.40], p = 0.042). CONCLUSION: This study concluded that high levels of serum CETP and chemerin were the risk factors for MS, while genotype AA CETP -629C/A gene polymorphism was not a risk factor for MS.

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“…In contrast to the present study, however, Heilbronn et al reported that BMI was higher in obese B1B2 participants, compared to obese subjects with B1B1 and B2B2 (33). Marou et al reported that Taq1B polymorphisms had no effect on related metabolic syndrome parameters, including WC (34). Also, some studies have shown that CETP polymorphism is not associated with anthropometric parameters (35,36).…”

Section: Discussionmentioning

confidence: 99%

Interaction between CETP Polymorphism and Dietary Insulin Index and Load on Cardiovascular Risk Factors: A Cross-Sectional Study of Diabetic adults

Abaj

Rafiee

Koohdani

2021

Preprint

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Background The objectives were to investigate the effect of the interaction between CETP Taq1B polymorphism, Dietary Insulin Index and Insulin Load (DII and DIL) on cardiovascular risk factors among diabetic patients. Methods In this cross-sectional study, blood samples were collected from 220 patients. DIL and DII were obtained via validated FFQ. CETP Taq1B polymorphism was genotyped by the PCR-RFLP method. Results The highest BMI (P = 0.08) and WC (P = 0.01) values were observed in B2B2 genotype with the highest adherence to DII. Patients with B1B1 genotype who were in the highest DIL tertile had lower LDL/HDL (P = 0.001), TG (P = 0.03), and higher HDL (P = 0.02). The highest SOD (P = 0.01), PGF2α (P = 0.04), CRP (P = 0.02), and IL-18 (P = 0.06) was observed in B2B2 genotype carriers with the highest DIL adherence. Individuals with B2B2 genotype in the highest tertile of DII had higher CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02). B1B1 homozygotes who were in the highest tertile of DII had lower lipid profile TG (P = 0.02), LDL (P = 0.08), and LDL/HDL < 0.001. Conclusion Based on the current study, it may be proposed that CETP Taq1B polymorphism can be associated with CVD risk factors in diabetic patients with high adherence to insulin indices, including DII and DIL

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Taq1B Polymorphism of Cholesteryl Ester Transfer Protein (CETP) and Its Effects on the Serum Lipid Levels in Metabolic Syndrome Patients

Cited by 18 publications

References 29 publications

Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

High Level of Serum Cholesteryl Ester Transfer Protein and Chemerin as a Risk Factor of Metabolic Syndrome in Adolescent Obese and the Description of Cholesteryl Ester Transfer Protein −629c/A Gene Promoter Polymorphism

Interaction between CETP Polymorphism and Dietary Insulin Index and Load on Cardiovascular Risk Factors: A Cross-Sectional Study of Diabetic adults

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