TGF-&lt;i&gt;β&lt;/i&gt;1 Induces Orthodontic Root Resorption through RANKL and IL-6 Production in hPDL Cells

Tsukada, Michiko; Kikuta, Jun; Shimizu, Mariko; Hikida, Takuji; Nakayama, Erika; Iwane, Takehiro; Kasai, Kazuhiko

doi:10.5466/ijoms.19.278

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Previous studies have reported that excessive compressive force enhanced PGE2, IL-1, IL-6, and TNF-α expression in PDL cells [23][24][25][26]. These factors stimulate RANKL expression in hPDL cells.…”

Section: Rankl Produced By Pdl Cells and Cementoblasts In Orrmentioning

confidence: 77%

The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption

Yamaguchi¹,

Mishima

2021

Applied Sciences

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Orthodontic root resorption (ORR) is an unintended side effect of orthodontic treatment, and severe ORR can affect treatment outcome. Receptor activator of nuclear factor kappa-B ligand (RANKL) has been detected in the resorbed cementum and periodontal (PDL) tissues exposed to excessive orthodontic forces. Recent studies have demonstrated that PDL cells and cementoblasts express RANKL that may play a role in ORR during orthodontic tooth movement. It is known that the hardness of cementum in human maxillary premolars differs among individuals. Furthermore, this difference has been reported to be attributed to differences in the calcium (Ca)/phosphorus (P) ratio. A correlation was observed between the Vickers hardness and Ca/P ratio of the cementum in the apical region. These findings suggest that cementum hardness and the Ca/P ratio may be indirectly involved in ORR caused by orthodontic forces. In this review, it aims to identify the role of RANKL and involvement of cementum in ORR.

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Section: Rankl Produced By Pdl Cells and Cementoblasts In Orrmentioning

confidence: 77%

The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption

Yamaguchi¹,

Mishima

2021

Applied Sciences

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“…11 Once the initial formation phase has been completed, the TGF-β1 osteoclast amount must be diminished to avoid alteration in osteoclastogenesis. Tsukada et al's 24 research reported that a high level of TGF-β1 on the seventh day after a large magnitude of orthodontics force was applied could trigger root resorption through increasing RANKL and interleukin-6 production by the periodontal tissue cells. In contrast to their study, this study applied minimal orthodontics strength, which caused a decline in TGF-β1 levels from day 7 to day 14 as a root resorption prevention mechanism.…”

Section: Discussionmentioning

confidence: 99%

Increased TGF-β1 level after cocoa administration during orthodontics tooth movement in Cavia cobaya

Fikri,

Farmasyanti,

Pudyani

2024

Dent. J.

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Background: Orthodontic tooth movement (OTM) is a process of tooth movement in the alveolar socket through a bone remodeling process. Cocoa contains caffeine as a bioactive component. The number of studies on the effects of caffeine on orthodontic tooth movement is rising. Purpose: This study aimed to determine the effect of caffeine in cocoa administration on TGF-β1 levels in the pressure side during orthodontic tooth movement. Methods: Twelve Cavia cobaya were divided into 4 groups: control group (ONC), treatment group with 2.3 mg caffeine in cocoa (OWC1), 3.45 mg dose (OWC2) and 4.6 mg dose (OWC3) (n=3). A NiTi open coil spring with light force was applied to two lower incisors tooth of Cavia cobaya. TGF-β1 level in GCF of the pressure side was analyzed using ELISA on days 0, 1, 7, and 14. Data were analyzed using the Two-way ANOVA test (p<0.05) and the LSD Post-Hoc test. Results: Research indicated improvement of TGF-β1 level from the control group with the least average followed group caffeine in cocoa 2.3 mg (OWC1), 3.45 mg (OWC2), and 4.6 mg (OWC3) (p<0.05). Conclusion: This study confirmed that caffeine in cocoa administration increase TGF-β1 level during orthodontics tooth movement on Cavia cobaya in the pressure side.

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Is Inflammation a Friend or Foe for Orthodontic Treatment?: Inflammation in Orthodontically Induced Inflammatory Root Resorption and Accelerating Tooth Movement

Yamaguchi¹,

Fukasawa²

2021

IJMS

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The aim of this paper is to provide a review on the role of inflammation in orthodontically induced inflammatory root resorption (OIIRR) and accelerating orthodontic tooth movement (AOTM) in orthodontic treatment. Orthodontic tooth movement (OTM) is stimulated by remodeling of the periodontal ligament (PDL) and alveolar bone. These remodeling activities and tooth displacement are involved in the occurrence of an inflammatory process in the periodontium, in response to orthodontic forces. Inflammatory mediators such as prostaglandins (PGs), interleukins (Ils; IL-1, -6, -17), the tumor necrosis factor (TNF)-α superfamily, and receptor activator of nuclear factor (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) are increased in the PDL during OTM. OIIRR is one of the accidental symptoms, and inflammatory mediators have been detected in resorbed roots, PDL, and alveolar bone exposed to heavy orthodontic force. Therefore, these inflammatory mediators are involved with the occurrence of OIIRR during orthodontic tooth movement. On the contrary, regional accelerating phenomenon (RAP) occurs after fractures and surgery such as osteotomies or bone grafting, and bone healing is accelerated by increasing osteoclasts and osteoblasts. Recently, tooth movement after surgical procedures such as corticotomy, corticision, piezocision, and micro-osteoperforation might be accelerated by RAP, which increases the bone metabolism. Therefore, inflammation may be involved in accelerated OTM (AOTM). The knowledge of inflammation during orthodontic treatment could be used in preventing OIIRR and AOTM.

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TGF-<i>β</i>1 Induces Orthodontic Root Resorption through RANKL and IL-6 Production in hPDL Cells

Cited by 3 publications

References 40 publications

The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption

The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption

Increased TGF-β1 level after cocoa administration during orthodontics tooth movement in Cavia cobaya

Is Inflammation a Friend or Foe for Orthodontic Treatment?: Inflammation in Orthodontically Induced Inflammatory Root Resorption and Accelerating Tooth Movement

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