The effect of carbon dioxide pneumoperitoneum on free radicals

Şare, Mustafa; Yılmaz, İsmet; Hamamci, D.; Birincioğlu, Mustafa; Özmen, Murat; Yeşilada, Özfer

doi:10.1007/s004640000168

Cited by 24 publications

(19 citation statements)

References 23 publications

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“…In addition, it is easily eliminated from the bloodstream through increased ventilation [3]. However, in recent years, many studies have shown that laparoscopic surgery may cause transient or persistent side effects in intra-abdominal or extra-abdominal organs that are closely related to the type, temperature, and pressure level of the gas used and the duration of the application [2][3][4][5]. Although some of these studies are extreme research models, it is known that stimulated immune response, cytokine releases in response to free radicals production, and ischemia/reperfusion model occur in almost all cases [6,7].…”

Section: Introductionmentioning

confidence: 98%

p53 expression and apoptosis in liver and spleen during CO2 pneumoperitoneum

Arıkan

Tosun

Şaykol

et al. 2007

Langenbecks Arch Surg

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Section: Introductionmentioning

confidence: 98%

p53 expression and apoptosis in liver and spleen during CO2 pneumoperitoneum

Arıkan

Tosun

Şaykol

et al. 2007

Langenbecks Arch Surg

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“…The immediate consequences of this relative ischemia were an elevation of various hepatic enzymes, including GOT (glutamic oxaloacetic transaminase) and GPT (glutamic pyruvic transaminase), reflecting hepatocytic damage [90], an impaired function of the Kupffer cells [91], a drop in gastric intramucosal pH [92], an increase in bacterial translocation from the gut, and an increased production of oxygen-derived free radicals [93]. These experimental results were obtained using intra-abdominal pressures ranging from 7 to 30 mm Hg.…”

Section: Splanchnic Ischemiamentioning

confidence: 99%

Circulatory and Respiratory Complications of Carbon Dioxide Insufflation

Gutt¹,

Oniu

Mehrabi³

et al. 2004

Dig Surg

308

272

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Background: Although providing excellent outcome results, laparoscopy also induces particular pathophysiological changes in response to pneumoperitoneum. Knowledge of the pathophysiology of a CO₂ pneumoperitoneum can help minimize complications while profiting from the benefits of laparoscopic surgery without concerns about its safety. Methods: A review of articles on the pathophysiological changes and complications of carbon dioxide pneumoperitoneum as well as prevention and treatment of these complications was performed using the Medline database. Results: The main pathophysiological changes during CO₂ pneumoperitoneum refer to the cardiovascular system and are mainly correlated with the amount of intra-abdominal pressure in combination with the patient’s position on the operating table. These changes are well tolerated even in older and more debilitated patients, and except for a slight increase in the incidence of cardiac arrhythmias, no other significant cardiovascular complications occur. Although there are important pulmonary pathophysiological changes, hypercarbia, hypoxemia and barotraumas, they would develop rarely since effective ventilation monitoring and techniques are applied. The alteration in splanchnic perfusion is proportional with the increase in intra-abdominal pressure and duration of pneumoperitoneum. Conclusion: A moderate-to-low intra-abdominal pressure (<12 mm Hg) can help limit the extent of the pathophysiological changes since consecutive organ dysfunctions are minimal, transient and do not influence the outcome.

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“…The dismutation of free oxygen radicals with SOD leads to the creation of H 2 O 2 . H 2 O 2 plays an important role as a free radical with different intra-abdominal pressures during CO 2 PP [56]. The activity of SOD would decrease after oxygen radicals are cleaned in liver tissues, indicating that the number of oxygen radicals is increased after CO 2 PP [57].…”

Section: Discussionmentioning

confidence: 98%

Effects of carbon dioxide pneumoperitoneum on hepatic function in obstructive jaundice: an experimental study in a rat model

Bostancı

Yol²,

Teke³

et al. 2009

Langenbecks Arch Surg

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Alterations in hepatic function occur in pneumoperitoneum applied jaundiced subjects. However, there were no statistically significant differences between the groups 2 and 4 with regard to white blood cell and platelet counts, serum liver enzymes including AST, ALT, and total bilirubin values, MDA and GSH levels and SOD activity of liver homogenate, and histologic damage. These results indicate that there is no additional risk on liver function associated with pneumoperitoneum performed in obstructive jaundice.

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The effect of carbon dioxide pneumoperitoneum on free radicals

Cited by 24 publications

References 23 publications

p53 expression and apoptosis in liver and spleen during CO2 pneumoperitoneum

p53 expression and apoptosis in liver and spleen during CO2 pneumoperitoneum

Circulatory and Respiratory Complications of Carbon Dioxide Insufflation

Effects of carbon dioxide pneumoperitoneum on hepatic function in obstructive jaundice: an experimental study in a rat model

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