The Effect of Orthodontic Retention on the Mechanical Properties of the Periodontal Ligament in the Rat Maxillary First Molar

Hong, Ryoon-Ki; Yamane, Akira; Kuwahara, Yosuke; Chiba, M.

doi:10.1177/00220345920710070101

Cited by 18 publications

(14 citation statements)

References 27 publications

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“…It has been shown that restoration of the mechanical strength of the PDL occurs in accordance with the closure of the interdental space after removal of the orthodontic force. 33 …”

Section: Discussionmentioning

confidence: 99%

Age-related effects on osteoclastic activities after orthodontic tooth movement

et al. 2016

Bone & Joint Research

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ObjectivesTo elucidate the effects of age on the expression levels of the receptor activator of the nuclear factor-κB ligand (RANKL) and osteoclasts in the periodontal ligament during orthodontic mechanical loading and post-orthodontic retention.Materials and MethodsThe study included 20 male Sprague-Dawley rats, ten in the young group (aged four to five weeks) and ten in the adult group (aged 18 to 20 weeks). In each rat, the upper-left first molar was subjected to a seven-day orthodontic force loading followed by a seven-day retention period. The upper-right first molar served as a control. The amount of orthodontic tooth movement was measured after seven-day force application and seven-day post-orthodontic retention. The expression levels of RANKL and the tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts were evaluated on day 7 (end of mechanical force loading) and day 14 (after seven days of post-orthodontic retention). Statistical analysis was performed using the t-test, and significance was set at p < 0.05.ResultsThere was no significant difference between the amount of tooth movement in the young group (0.96, standard deviation (sd) 0.30mm) and that in the adult group (0.80mm, sd 0.28) (p > 0.05) after the seven-day force application. On the compression side, the expression of RANKL and TRAP-positive osteoclasts in both the young and the adult groups increased after the application of force for seven days, and then decreased at the end of the seven-day retention period. However, by the end of the period, the expression of RANKL on the compression side dropped to the control level in the young group (p > 0.05), while it was still higher than that on the control side in the adult group (p < 0.05). The expression of RANKL on the compression side did not show significant difference between the young and the adult groups after seven-day force application (p > 0.05), but it was significantly higher in the adult group than that in the young group after seven-day post-orthodontic retention (p < 0.05). Similarly, the decreasing trend of TRAP-positive osteoclasts during the retention period in the adult group was less obvious than that in the young group.ConclusionsThe bone-resorptive activity in the young rats was more dynamic than that in the adult rats. The expression of RANKL and the number of osteoclasts in adult rats did not drop to the control level during the post-orthodontic retention period while RANKL expression and the number of osteoclasts in young rats had returned to the baseline.Cite this article: X. Li, M. Li, J. Lu, Y. Hu, L. Cui, D. Zhang, Y. Yang. Age-related effects on osteoclastic activities after orthodontic tooth movement. Bone Joint Res 2016;5:492–499. DOI: 10.1302/2046-3758.510.BJR-2016-0004.R2.

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“…It has been shown that restoration of the mechanical strength of the PDL occurs in accordance with the closure of the interdental space after removal of the orthodontic force. 33 …”

Section: Discussionmentioning

confidence: 99%

Age-related effects on osteoclastic activities after orthodontic tooth movement

et al. 2016

Bone & Joint Research

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“…Many studies have been conducted in an attempt to determine the optimal duration of periodontal stabilization. [13][14][15] An histological approach cannot be applied to patients directly, and a radiological approach can be considered strongly subjective in nature; neither is helpful in assessing the stabilization of the periodontal ligament. Tooth mobility, however, can be used on a longitudinal basis as an indicator of biological changes within the periodontal ligament.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal measurements of tooth mobility following orthodontic treatment

Hwang

Kim

Kim³

et al. 2010

Korean J Orthod

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Objective:The aim of the present study was to evaluate the changes in tooth mobility following orthodontic treatment and to obtain information regarding the guideline of retainer wear duration during the post-treatment period. Methods: The sample consisted of twenty patients who had been treated with edgewise appliances. The mobility of the maxillary teeth from the central incisor to the first molar was measured bilaterally by way of the Periotest Ⓡ , a non-invasive, electronic device that provides an objective measurement of the reaction of the periodontium to a defined impact load. Tooth mobility was monitored at the time of the removal of the orthodontic appliances and subsequently at three-month intervals during the two years following appliance removal. Results: Tooth mobility decreased rapidly for the first six months and then decreased at a slower rate during the next six months; no statistically significant decrease in mobility was observed during the second year following appliance removal. Conclusions: The results of the present study suggest that adequate tooth stabilization is critical during the first six months following appliance removal and that continued wearing of retainers is recommended at least until twelve months after the completion of orthodontic treatment. (Korean J Orthod 2010;40(1):34-39)

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“…Tooth movement was estimated by subtracting the mean of the repeated measured values from the untreated and treated sides (Figure 1b) as described by Hong et al 28 The error of the method based on double measurements performed on 20 randomly selected animals was estimated by using Dahlberg's equation (S ϭ , where n ϭ num-2 ͙⌺ d /2n ber of paired measurements and d ϭ deviations between the two measurements 29 ). The error in measurement was 0.02 mm and was thus considered to be of no further importance.…”

Section: Methodsmentioning

confidence: 99%

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

Gameiro

Noüer

Neto

et al. 2008

The Angle Orthodontist

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Objective: To test the hypothesis that short-and long-term celecoxib administration has no effect on orthodontic tooth movement. Materials and Methods: Male Wistar rats were submitted to short-(3 days) and long-term (14 days) celecoxib administration, while the respective control groups received equivolumetric saline intraperitoneal injections. The upper left first molars of all rats were moved mesially for 14 days by a fixed orthodontic appliance exerting 50 g force upon insertion. After the experimental period, tooth movement was quantified and tissues around the first molar were processed for tartrateresistant acid phosphatase (TRAP) histochemistry. The amount of tooth movement and the number of TRAP-positive cells on the alveolar bone surface were evaluated. Results: The amount of tooth movement was significantly reduced in rats submitted to short-and long-term celecoxib administration, while the number of osteoclasts on the alveolar bone did not differ between the four groups studied. Conclusions: The hypothesis is rejected. Although celecoxib administration did not affect the number of osteoclasts, the osteoclast activity might be reduced, which could explain the inhibition of tooth movement observed in the celecoxib-treated animals. These results indicate that orthodontists should be aware of patients under short-and long-term therapy with celecoxib.

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The Effect of Orthodontic Retention on the Mechanical Properties of the Periodontal Ligament in the Rat Maxillary First Molar

Cited by 18 publications

References 27 publications

Age-related effects on osteoclastic activities after orthodontic tooth movement

Age-related effects on osteoclastic activities after orthodontic tooth movement

Longitudinal measurements of tooth mobility following orthodontic treatment

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

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