The Feasibility of a Handheld Electrospinning Device for the Application of Nanofibrous Wound Dressings

Abstract

{These authors contributed equally to this work. Objectives:The aim of this study was to determine the feasibility of a portable electrospinning device for the application of wound dressings. Approach: Four polymer nanofibers dressings were applied on superficial partial thickness wounds to a porcine model and compared with a traditional paraffin tulle gras dressing. The polymer nanofibrous dressings were applied using a handheld portable electrospinning device activated at a short distance from the wound. The partial thickness donor sites were evaluated on day 2, 7, and 14 when dressings were removed and tissue samples were taken for histological examination. Results: No significant difference was detected between the different electrospun nanofibrous dressings and traditional paraffin tulle gras. Desirable characteristics of the electrospun nanofiber dressing group included nontouch technique, ease of application, adherence and reduction in wound edema and inflammation. There was no delayed wound healing or signs of infection reported in both the electrospun nanofiber and traditional tulle gras dressings. Innovation: Used on partial thickness wounds, polymer electrospun nanofiber dressings provide excellent surface topography and are a nontouch, feasible, and safe method to promote wound healing with the potential to reduce wound infections. Such custom-made nanofibrous dressings have implications for the reduction of pain and trauma, number of dressing changes, scarring, and an added cost benefit. Conclusion: We have demonstrated that this portable handheld electrospinning device can be utilized for different formulations and materials and customized according to the characteristics of the target wound at the various stages of wound healing.

Nanomaterials for Wound Healing and Infection Control

“…Regarding safety (risk of infection, delayed healing) the results were similar to the traditional paraffin tulle gras dressing. The non-touch technique and the ease of application represent advantages of this therapeutic option [57].…”

Azobenzene-Containing Liquid Crystalline Composites for Robust Ultraviolet Detectors Based on Conversion of Illuminance-Mechanical Stress-Electric Signals

“…A handheld electrospinning device is used to prepare conformal UV shielding fabrics facilely ( Figure S9). 36 Moreover, the LCP-TPU fabrics can redissolve in DMF/THF solutions for the recycling fabrication. To evaluate the UV shielding property, the ultraviolet protection factor (UPF) was calculated based on the GB/T 18830-2009 evaluation method, detailed in Section S3 (Supplementary Information).…”

In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments

“…The incorporation of electrospinning in in situ biomedical applications creates important challenges for how to re-design conventional electrospinning devices, which use high voltages and have limited portability, to become portable user-friendly equipment that can be used in the "patient's bed." Therefore, great efforts have been made to develop new portable electrospinning devices for the purposes of wound dressing and regeneration (Xu et al, 2015;Haik et al, 2017). An example is the SkinCare (Figure 2), a portable wound care system developed by Nanomedic Technologies Ltd (2019) in Israel.…”