The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome

Bachiller, Daniel; Klingensmith, John; Shneyder, Natalya; Tran, Uyen; Anderson, Ryan M.; Rossant, Janet; Robertis, E. M. De

doi:10.1242/dev.00581

Cited by 161 publications

(138 citation statements)

References 63 publications

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“…In common with mouse (Chapman et al, 1996;Garg et al, 2001;Lindsay et al, 2001), chick (Garg et al, 2001), lamprey (SaukaSpengler et al, 2002), and zebrafish (Kochilas et al, 2003;Piotrowski et al, 2003) embryos, the pharyngeal mesoderm and endoderm are among the most prominent sites of expression, along with the otic vesicle. We also detected low levels of Tbx1 in the presumptive mesoderm of gastrulating embryos and in the lateral mesoderm at neurula stages, sites of expression that have been noted in the mouse (Chapman et al, 1996;Bachiller et al, 2003) and zebrafish (SaukaSpengler et al, 2002;Kochilas et al, 2003). In the absence of a known direct transcriptional target of Tbx1, we used a CAT reporter vector containing a single iteration of the consensus Brachyury binding site.…”

Section: Discussionmentioning

confidence: 79%

XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis

Ataliotis¹,

Ivins²,

Mohun

et al. 2005

Developmental Dynamics

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The development of pharyngeal arch derivatives in mouse and zebrafish embryos depends on the activity of the transcription factor Tbx1. We cloned the Xenopus laevis orthologue of Tbx1 (XTbx1) and show that the pattern of expression is similar to that in other vertebrate species. Zygotic transcripts are first detected shortly after the mid-blastula transition and are localized to the presumptive mesoderm at mid-gastrula stages. XTbx1 expression persists in the lateral plate mesoderm at neurula stages and is found in the pharyngeal arches and otic vesicles from early tail bud stages onward. We demonstrate that XTbx1 is a transcriptional activator and that this trans-activation requires the C-terminal region of the protein.

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Section: Discussionmentioning

confidence: 79%

XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis

Ataliotis¹,

Ivins²,

Mohun

et al. 2005

Developmental Dynamics

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“…Cells exiting at the posterior end of the primitive streak move into the extra-embryonic region where they give rise to a mesodermal lineage (allantoids, amnion and blood islands of the yolk sac). By contrast, cells located in more anterior regions of the streak remain inside the embryo proper and produce the paraxial, intermediate and lateral plate mesoderm of the future trunk (Bachiller et al 2003).…”

Section: Development Of the Embryonic Heartmentioning

confidence: 98%

Isolation, Characterization and Differentiation Potential of Cardiac Progenitor Cells in Adult Pigs

Vanelli

Pennarossa

Maffei

et al. 2012

Stem Cell Rev and Rep

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“…As the small thyroid in this mutant has a largely normal shape this suggests that NCC might be required for growth rather than bilobation. Thyroid hypoplasia accompanied by diminished NCC infiltration of the pharyngeal arches is also observed in mice deficient of Pax3 (radiation induced in the splotch mutant) (Franz, 1989), fibulin-1 (Cooley et al, 2008) and the natural BMP antagonist chordin (Bachiller et al, 2003). Whether the NC influences thyroid growth directly by local action of NCC infiltrating the embryonic thyroid stroma or Page 43 of 68 A c c e p t e d M a n u s c r i p t 43 indirectly through gross changes of pharyngeal patterning characterising the NCC ablated embryo need further studies to be elucidated.…”

Section: Role Of Neural Crest In Thyroid Morphogenesismentioning

confidence: 94%

Morphogenesis of the thyroid gland

Fagman

Nilsson

2010

Molecular and Cellular Endocrinology

130

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Congenital hypothyroidism is mainly due to structural defects of the thyroid gland, collectively known as thyroid dysgenesis. The two most prevalent forms of this condition are abnormal localization of differentiated thyroid tissue (thyroid ectopia) and total absence of the gland (athyreosis). The clinical picture of thyroid dysgenesis suggests that impaired specification, proliferation and survival of thyroid precursor cells and loss of concerted movement of these cells in a distinct spatiotemporal pattern are major causes of malformation. In normal development the thyroid primordium is first distinguished as a thickening of the anterior foregut endoderm at the base of the prospective tongue. Subsequently, this group of progenitors detaches from the endoderm, moves caudally and ultimately differentiates into hormone-producing units, the thyroid follicles, at a distant location from the site of specification. In higher vertebrates later stages of thyroid morphogenesis are characterized by shape remodelling into a bilobed organ and the integration of a second type of progenitors derived from the caudal-most pharyngeal pouches that will differentiate into C-cells. The present knowledge of thyroid developmental dynamics has emerged from embryonic studies mainly in chicken, mouse and more recently also in zebrafish. This review will highlight the key morphogenetic steps of thyroid organogenesis and pinpoint which crucial regulatory mechanisms are yet to be uncovered. Considering the coincidence of thyroid dysgenesis and congenital heart malformations the possible interactions between thyroid and cardiovascular development will also be discussed.

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The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome

Cited by 161 publications

References 63 publications

XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis

XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis

Isolation, Characterization and Differentiation Potential of Cardiac Progenitor Cells in Adult Pigs

Morphogenesis of the thyroid gland

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