The role of HSP90 in Quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells

Altundağ, Ergül Mutlu; Yılmaz, Ayşe Mine; Kasaci, Tolga; Corek, Ceyda; Taga, Yavuz; Yalçın, A. Süha

doi:10.1016/j.freeradbiomed.2014.10.797

Cited by 11 publications

(4 citation statements)

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“…On the other hand, a combination of quercetin and SNS‐314 results in a synergistic cytotoxic effect on medullary TT and papillary BCPAP cell lines with a significant decrease of the IC 50 value (Quagliariello et al, ). Similarly, treatment of thyroid papillary cancer cell lines with different concentrations of quercetin (between 10 and 75 μM) for 24 hr induces apoptosis by inhibiting HSP production on various cancer cell lines (Mutlu Altundag et al, ).…”

Section: Anticancer Perspectives Of Quercetinmentioning

confidence: 99%

Anticancer potential of quercetin: A comprehensive review

Rauf

Imran

Khan

et al. 2018

Phytotherapy Research

503

276

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Diet plays a key role to maintaining healthy life. Many natural products present in our diet, such as flavonoids, can prevent the progression of cancer. Quercetin, a distinctive bioactive flavonoid, is a dietary component that has attracted the attention of dietitians and medicinal chemists due to its numerous health-promoting effects. It is an outstanding antioxidant that has a well-documented role in reducing different human cancers. Quercetin exhibits direct proapoptotic effects on tumor cells and thus can inhibit the progress of numerous human cancers. The anticancer effect of quercetin has been documented in numerous in vitro and in vivo studies that involved several cell lines and animal models. On the other hand, the high toxic effect of quercetin against cancer cells is accompanied with little or no side effects or harm to normal cells. Accordingly, this review presents an overview of recent developments on the use of quercetin against different types of cancer along with mechanisms of action. In addition, the present review summarizes the literature pertaining to quercetin as an anticancer agent and provides an assessment of the potential utilization of this natural compound as a complimentary or alternative medicine for preventing and treating cancer.

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Section: Anticancer Perspectives Of Quercetinmentioning

confidence: 99%

Anticancer potential of quercetin: A comprehensive review

Rauf

Imran

Khan

et al. 2018

Phytotherapy Research

503

276

View full text Add to dashboard Cite

show abstract

“…Moreover, quercetin decreases the expression of thyroid-stimulating-hormone-modulated thyroid-restricted gene sodium/iodide symporter (NIS) [96,97]. By contrast, treatment with 50∼75 μM quercetin shows an excellent anticancer activity by inducing S phase arrest and apoptosis via Hsp90 and Caspase-3/PARP pathways in BCPAP cells [41,42]. Similarly, myricetin, of which the B ring presents one more hydroxyl group at the 5′ position compared with quercetin, dependently induces apoptosis and DNA condensation of SNU-790 PTC cells, which also involves caspase-dependent mitochondrial dysfunction [43].…”

Section: Flavonoidsmentioning

confidence: 99%

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

Yang

Chen

et al. 2020

BioMed Research International

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Papillary thyroid carcinoma (PTC) is the most common subtype of differentiated thyroid cancers in Asian coastal cities, where the patients have increased risk of potentially high or excessive iodine intake. Given the high metastasis and recurrence of patients with BRAFV600E mutation, the mortality rate of thyroid cancer has recently shown an upward trend. A variety of therapies, including surgery, radiotherapy, and chemotherapy, have been used to treat thyroid cancer, but these therapies still have limitations, including postoperative complications, drug resistance, poor efficacy, or serious side effects. Recent studies have shown the potential of active ingredients derived from herbal medicine in inhibiting PTC via various cell signaling pathways. Some plant-derived compounds, such as apigenin, genistein, and curcumin, are also known to prevent and treat PTC. This article summarizes the recent advances in the structure-functional impact of anti-PTC active ingredients and their effects on PTC cells and tumor microenvironments with an emphasis on their challenges from basic research to clinical practice.

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“…Quercetin is known as an inhibitor of heat shock protein (Hsp), which can be used in cancer therapy. Treatment with quercetin can induce apoptosis by down-regulating Hsp90, which inhibits the activation of chymotrypsin-like proteasome in PTC B-CPAP cell line [76,77]. In heat therapy, hyperthermia is known to damage cancer cells due to high temperature [78].…”

Section: Anticancer Effects Of Phytochemicals On Thyroid Cancersmentioning

confidence: 99%

Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

2019

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Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side effects. Phytochemicals are plant-derived chemicals having various physiological activities that are expected to be effective in cancer treatment. In this review, anticancer efficacy of phytochemicals, such as resveratrol, genistein, curcumin, and other substances in each type of thyroid cancer was introduced with their chemopreventive mechanisms. English articles related with thyroid cancer and anti-thyroid cancer of phytochemicals were searched from PubMed and Google Scholar. This article mainly focused on in vitro or animal studies on phytochemicals with anti-thyroid cancer activity. These various phytochemicals have been shown to induce apoptosis in all types of thyroid cancer cells, inhibit cell proliferation and invasion, and to be helpful in enhancing the effect of radioiodine therapy that is a typical therapy to thyroid cancer. These results suggest that thyroid cancer can be more effectively treated by the combinations of phytochemicals and the existing therapies or substances.

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The role of HSP90 in Quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells

Cited by 11 publications

References 0 publications

Anticancer potential of quercetin: A comprehensive review

Anticancer potential of quercetin: A comprehensive review

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

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