The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants

Kanner, Joseph; Lapidot, Tair

doi:10.1016/s0891-5849(01)00718-3

Cited by 310 publications

(320 citation statements)

References 43 publications

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“…They can scavenge free radicals locally in the stomach, preventing lipid peroxidation and, at the same time, spare other antioxidants from oxidation. By this way, although acting locally, the polyphenols (Kanner & Lapidot, 2001).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Kuate¹,

Kengne²,

Dakam³

et al. 2013

JFR

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This work evaluated the effect of Dichrostachys glomerata on the improvement of antioxidant biomarkers in obesity and type 2 diabetes participants, in an eight-week randomized, double-blind, placebo-controlled design study. The active (400 mg) or placebo formulation were administered twice daily throughout the study period to two normoglycemic and two diabetic obese random groups. Plasma levels of a total of 8 biochemical parameters were taken at the baseline and after 4 and 8 weeks of treatment. No differences in urate variation were observed while the plasma phenolic content as well as the reduced glutathione level, ascorbate concentration, FRAP value and enzymatic antioxidant activities significantly increased with a concomitant reduction of MDA after 8 weeks compared to placebo (P < 0.01). On the contrary to urate and ascorbate, plasma polyphenol content correlated well with FRAP level in both treated groups indicating that phenolics from the spice greatly contributed to the antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Kuate¹,

Kengne²,

Dakam³

et al. 2013

JFR

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“…Clinical research has confirmed the efficacy of several plants for the treatment of gastroduodenal disease, while basic scientific research has uncovered the mechanisms by which some plants exert their therapeutic effects (8,9).…”

Section: Oxidative Stress In Gastric Mucosamentioning

confidence: 99%

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Repetto

Llesuy

2002

Braz J Med Biol Res

432

277

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There is evidence concerning the participation of reactive oxygen species in the etiology and physiopathology of human diseases, such as neurodegenerative disorders, inflammation, viral infections, autoimmune pathologies, and digestive system disorders such as gastrointestinal inflammation and gastric ulcer. The role of these reactive oxygen species in several diseases and the potential antioxidant protective effect of natural compounds on affected tissues are topics of high current interest. To consider a natural compound or a drug as an antioxidant substance it is necessary to investigate its antioxidant properties in vitro and then to evaluate its antioxidant functions in biological systems. In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol.

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“…Clinical research has confirmed the efficiency of several plants for the treatment of gastroduodenal diseases 13,14 . The medicinal properties of many plants are mainly assigned to the flavonoids present, but they may be influenced also by other compounds such as coumarins, alkaloids, terpenoids, tannins, phenolic acids and antioxidant micronutrients, e.g.…”

Section: Introductionmentioning

confidence: 96%

Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and α-chymotrypsin

Păun

Liţescu

Neagu

et al. 2013

Journal of Enzyme Inhibition and Medicinal Chemistry

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This study was meant to determine the inhibitory activity of tannins and flavonoid compounds from Geranium robertianum, Helleborus purpurascens and Hyssopus officinale plant polyphenol rich extracts against urease and a-chymotrypsin. The G. robertianum, H. purpurascens and H. officinale extracts were purified and concentrated by microfiltration and ultrafiltration. Phenolic compounds including flavonoids and tannins have been linked to many pharmacological activities. Thus, the polyphenolic content of the extracts was assessed by UV-Vis spectroscopy and HPLC. The concentrated extracts enriched in polyphenolic compounds (flavonoids, tannins and phenolic acids) showed a significant inhibition against urease from jack bean (over 90%), whereas in case of the a-chymotrypsin, they proved to have an inhibition below 54%. The results of this support the use of G. robertianum, H. purpurascens and H. officinale polyphenolic extracts as potential sources of urease inhibitors. Among the three plant extracts tested, H. officinale polyphenolic extracts exhibited a high inhibitory activity (92.67%) against urease and low inhibition (19.6%) against a-chymotrypsin and could be considered as possible remedy in ulcer treatment.

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The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants

Cited by 310 publications

References 43 publications

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and α-chymotrypsin

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