The use of marine-derived bioactive compounds as potential hepatoprotective agents

Nair, Dileep G.; Weiskirchen, Ralf; Al-Musharafi, S. K.

doi:10.1038/aps.2014.114

Cited by 38 publications

(24 citation statements)

References 97 publications

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“…The use of natural products in the prevention and treatment of liver diseases has gained considerable popularity (Zhang et al, 2013; Nair et al, 2014; Jaeschke et al, 2011; 2013). Among these products, resveratrol (RSV), a natural polyphenolic compound primarily found in the skin of grapes, is particularly well-studied (Bishayee et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

McGill

Xie

et al. 2015

Food and Chemical Toxicology

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Overdose of acetaminophen (APAP) is a common cause of acute liver injury and liver failure. The mechanism involves formation of a reactive metabolite, protein binding, oxidative stress and activation of c-Jun N-terminal kinase (JNK), mitochondrial dysfunction, and nuclear DNA fragmentation caused by endonucleases released from damaged mitochondria. Previous work has shown that the natural product resveratrol (RSV) can protect against APAP hepatotoxicity in mice through prevention of lipid peroxidation and anti-inflammatory effects. However, these earlier studies did not take into consideration several fundamental aspects of the pathophysiology. To address this, we treated C57Bl/6 mice with 300 mg/kg APAP followed by 50 mg/kg RSV 1.5h later. Our results confirmed that RSV reduced liver injury after APAP overdose in mice. Importantly, RSV did not inhibit reactive metabolite formation and protein bindings, nor did it reduce activation of JNK. However, RSV decreased protein nitration after APAP treatment, possibly through direct scavenging of peroxynitrite. Interestingly, RSV also inhibited release of apoptosis-inducing factor and endonuclease G from mitochondria independent of Bax pore formation and prevented the downstream nuclear DNA fragmentation. Our data show that RSV protects against APAP hepatotoxicity both through antioxidant effects and by preventing mitochondrial release of endonucleases and nuclear DNA damage.

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Section: Introductionmentioning

confidence: 99%

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

McGill

Xie

et al. 2015

Food and Chemical Toxicology

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“…Marine environment exhibits extremely harsh physical and chemical environmental conditions that drive the researchers' towards the production of different molecules with unique structural features when compared to the terrestrial ecosystem. Invariably, the land holds up a total of only 12 phyla, whereas the marine stream comprises a total of 32 phyla [17,18]. A recent census shows that the field of marine research transcends across 80 nations, involving more than 2700 scientists, concentrating on diversity, distribution and discovering potential drugs from various marine sources [19].…”

Section: The Marine Diversitymentioning

confidence: 99%

“…Moreover, the marine system produces an inexhaustible and rich source of potential natural products with a wide array of nutraceutical, cosmeceutical and unique pharmaceutical activities. More than 30000 compounds have been identified from the marine environment with unique structures and associated pharmaceutical activity [18]. Figure 1 shows the decade-wise increase in the exploration of new bioactive compounds from marine sources from 1971 to 2010.…”

Section: The Marine Diversitymentioning

confidence: 99%

Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

Manig¹,

Ramachandran²,

Saravanan³

2015

J Neurol Neurosci

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Neurological disorders occur due to recognition of neurological repairs and resources are indirectly scarce, especially in low income and developing countries. They are disorders of the central nervous system and common cause of physiological and economic burden worldwide. Alzheimer's disease (AD) and other dementias is one of the progressive neurodegenerative disorders which causes memory loss and cognitive impairment due to aggregation of misfolded proteins and neurofibrillar tangles in brain. The failure of the conventional drugs to decline disease progression accompanied with numerous adverse effects has forced the researchers to look for efficient drug candidates from alternate natural resources. The marine reservoir with its large biodiversity and untapped resource potential holds numerous molecules of biomedical and clinical importance. In this review, we hypothesize the utilization of the sulfated polysaccharides as glycobased mimetics, leading to the prevention of aggregation of plaques and protein tangles. With further screening and validation, the carbohydrates from the marine sources, thus hold immense potentials to function as alternative therapeutic agent against neurological disorders.

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“…In general, hepatitis due to drugs does not cause permanent damage, but sometimes it can persist and has fatal effect. Hepatotoxic is a chemical causing some toxic effects on liver cells [2]. With the excessive doses (toxic doses) or long-term retreating, this compound can cause an acute or chronic liver damage [3].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sea Cucumber (Holothuria Scabra) Extract as Hepatoprotective: Histopathological Study

Abdulkadir

Tungadi

2018

Asian J Pharm Clin Res

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Objective: Sea cucumber Holothuria scabra is one of the marine animals that can be consumed as food and also efficacious as a drug. One of the benefits of sea cucumber has high cell regeneration ability. This study aims to see the profile of hepatoprotective histology of sea cucumber extract on mice that have been given paracetamol toxic dose.Methods: This experiment was conducted using experimental animal grouped of mice which were divided into six groups: Group I: sea cucumber extract 1%, Group II: 1000 mg/kg body weight (BW) or 25 mg/25 g BW, Group III: 750 mg/kg BW or 18.75 mg/25 g BW, Group IV: 500 mg/kg BW or 12.5 mg/25 g BW, Group V: positive control (curcuma tablet 2.5 mg/25 g BW), and Group VI: paracetamol group (62,5 mg/25 g BW). The histopathology test was performed to see the improvement of liver necrosis of mice.Results: The results of histopathological study showed that all groups of mice livers experienced necrosis (cell damage) and abnormalities. In the group of sea cucumber extract having dose 500 mg/kg BW, liver cells experienced degeneration of fat and hemorrhage as in the group of curcuma tablet, but in Group VI (paracetamol group), liver of mice experienced apoptosis (cell death). In the histopathology test, results can also be seen that in Group IV at doses of 500 mg/kg BW, the liver experienced slightly less severity than all other groups.Conclusion: The sea cucumber at doses of 500 mg/kg BW can improve the hepatic damage on mice induced by paracetamol.

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The use of marine-derived bioactive compounds as potential hepatoprotective agents

Cited by 38 publications

References 97 publications

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

The Effect of Sea Cucumber (Holothuria Scabra) Extract as Hepatoprotective: Histopathological Study

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