Three new oleanane-type triterpene saponins from Atractylis flava

Chabani, Sonia; Lavaud, Catherine; Benkhaled, Mohammed; Harakat, Dominique; Long, Christophe; Haba, Hamada

doi:10.1016/j.phytol.2015.11.017

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…6,7 Phytochemical investigations of the whole plant revealed the presence of triterpenes, steroids, saponins and flavonoids. 8 Furthermore, the presence of a tiliroside, narcissin, vicenin3, ladaneine and schaftoside was confirmed in the n-butanol extract of this plant. 8,9 However, no data were found regarding the pharmacological evaluation of the plant.…”

Section: Introductionmentioning

confidence: 75%

“…8 Furthermore, the presence of a tiliroside, narcissin, vicenin3, ladaneine and schaftoside was confirmed in the n-butanol extract of this plant. 8,9 However, no data were found regarding the pharmacological evaluation of the plant. The aim of the present study is to evaluate the antiinflammatory and antipyretic properties of the n-butanol extract of the whole plant Atractylis flava Desf (BEAF).…”

Section: Introductionmentioning

confidence: 75%

“…Furthermore, the presence of a tiliroside, narcissin, vicenin 3, ladaneine and schaftoside were detected in the n-butanol extract. 8,9 Flavonoids have been demonstrated that they are able to inhibit a series of enzymes, which are activated in the course of the inflammatory process. 26 Also, flavonoid such as vicenin-2, Tiliroside, Schaftoside, have been recognized as potent inhibitors of pro-inflammatory mediators in different studies.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Akram¹,

Benkiki²,

Eddine³

et al. 2018

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Objectives:This study was aimed to explore the antipyretic and anti-inflammatory effects of n-butanol etract of Atractylis flava Desf (A. flava) using experimentally induced inflammation and pyrexia models in rats. Methods: In the acute toxicity study, a single oral dose of 2000 mg/kg of n-butanol extract was given to rats. The antipyretic activity was evaluated using brewer's yeast induced pyrexia in rats. In addition, albumin induced rat paw edema was performed by the injection of 100 µL undiluted fresh egg albumin to assess the anti-inflammatory effects of the plant. Results: The results of the present study revealed that n-butanol extract of A. flava significantly (P<0.001) reduced fresh egg albumin-induced rat paw edema and also inhibited fever significantly in brewer's yeast induced pyrexia. Conclusion: The results of the present study indicated that A. flava possesses antipyretic and anti-inflammatory activity in the models studied.

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Section: Introductionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Akram¹,

Benkiki²,

Eddine³

et al. 2018

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“…The Atractylis species are used in folk medicine against urinary retention, intestinal parasites and snakebite poisoning, and for their anti-inflammatory and antipyretic activities (Larrey and Pageaux, 1995, El Rhaffari and Zaid 2002, Daniele et al 2005, Melakhessou et al 2018). In addition, many studies have been reported for Atractylis plants, which allowed the identification of diterpenes, triterpenes, saponins and flavonoids (Sadek et al 1998, Chabani et al 2013, Chabani et al 2016a, Chabani et al 2016b. Atractylis cancellata L., used in folk medicine for the treatment of skin disorders (Bammou et al 2015), is an herbaceous endemic plant; it grows in semi-arid zone of Mediterranean area (Quezel and Santa 1963).…”

Section: Introductionmentioning

confidence: 99%

Pyrroloquinolone A, a new alkaloid and other phytochemicals from Atractylis cancellata L. with antioxidant and anticholinesterase activities

Badaoui

Magid

Benkhaled

et al. 2019

Natural Product Research

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A new alkaloid pyrroloquinolone A (1), along with fifteen known compounds 2-16 were isolated from the petroleum ether, EtOAc and n-BuOH extracts of the whole plant Atractylis cancellata L. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D-and 2D-NMR and HR-ESI-MS techniques. This is the first report of alkaloids in the genus Atractylis. Some of the isolated compounds and extracts were evaluated for their antioxidant potential (scavenging activity of DPPH and ABTS radicals, and reducing Fe +3 and Cu +2 power assays) and acetylcholinesterase and butyrylcholinesterase inhibitory activities.Compounds 8 and 11 showed good antioxidant capacity compared to ascorbic acid, BHA, and BHT used as standards, whereas compounds 1 and 2 exhibited good anticholinesterase activities compared to galantamine used as standard.

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“…Therefore, the knowledge about phytochemical investigations of Atractylis plants is very scanty, amongst these plants; A. flava, A. macroceohala and A. gummifera from which flavonoids, polysaccharide, triterpenes and diterpenes were identified. 6,7 Moreover, Atractylis species are used as general remedies in traditional medicine for treatment of various diseases such as inflammation, ulcer, tumor and circulatory disorders, hepatitis, when Atractylis flava Desf is particularly known in traditional North African medicine for its diuretic effects. [8][9][10] The objective of this study was to examine the cytotoxic effects of Atractylis flava Desf.…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Levels of Selected Factors in Monocytic Leukemia Cell Line THP-1 Upon Treatment with n-butanol Extract of Atractylis flava Desf against Cancer

Akram¹,

Naima²,

Eddine³

et al. 2018

JYP

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Objective: The aim of the present study was to screen the anticancer activity of Atractylis flava Desf in butanolic extract (AFBE). In addition, we attempted to investigate the gene expression levels of seven relevant genes involved in the pathways leading to toxicity: oxidative stress (NCF1, OPA1, SDHA), inflammation (TNFα), apoptotic balance (PDCD4, BCL2, CASP8) and the measurement of caspase-3 activity on the acute monocytic leukemia cell line THP-1. Material and Methods: The cell viability was assessed using Trypan blue exclusion, alamarBlue® and WST-1 assays. The gene expression levels were tested by RT-qPCR. Activity of caspase-3 activity was performed using the EnzChek® Caspase-3 Assay kit to confirm the induction of apoptosis on tumor cells. Results: We observed significant growth inhibitory activity of the AFBE extract on the acute monocytic leukemia cell line THP-1. Moreover, the gene expression analysis showed that the plant extract caused statistically significant downregulation of selected genes compared to the untreated cells. Caspase-3 activity in the treated cells was significantly elevated. Conclusion: The presents study states that the butanolic extract of Atractylis flava Desf showed a significant cytotoxic effect against THP-1 cells. Our results suggest that the AFBE may be beneficial for the treatment and prevention of cancer.

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Three new oleanane-type triterpene saponins from Atractylis flava

Cited by 15 publications

References 11 publications

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Pyrroloquinolone A, a new alkaloid and other phytochemicals from Atractylis cancellata L. with antioxidant and anticholinesterase activities

Gene Expression Levels of Selected Factors in Monocytic Leukemia Cell Line THP-1 Upon Treatment with n-butanol Extract of Atractylis flava Desf against Cancer

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