Two new metabolites from the endophytic fungus Xylaria sp. isolated from the medicinal plant Curcuma xanthorrhiza

Hammerschmidt, Lena; Ola, Antonius R. B.; Müller, Werner; Lin, Wenhan; Mándi, Attila; Kurtán, Tibor; Proksch, Peter; Aly, Amal H.

doi:10.1016/j.tetlet.2014.12.120

Cited by 23 publications

(12 citation statements)

References 24 publications

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“…isolated from the medicinal plant Curcuma xanthorrhiza , collected on the island of Timor, Indonesia afforded two new compounds, arugosin J ( 20 ) and xylarugosin ( 21 ). The two metabolites 20 and 21 were inactive (IC 50 > 50 μM) when tested for cytotoxicity against the murine cancer cell line L5178Y by the MTT assay (Hammerschmidt et al, 2015 ). The Diaporthe genus is the sexual form of Phomopsis , and these are important endophytic fungi obtained from tropical and temperate woody plants.…”

Section: Current Screening Studies For Endophytes and Their Metabolitmentioning

confidence: 99%

Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes

Abdalla

McGaw

2018

Front. Pharmacol.

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South Africa has a long history and strong belief in traditional herbal medicines. Using ethnobotanical knowledge as a lead, a large number of South African medicinal plants have been discovered to possess a wide spectrum of pharmacological properties. In this review, bioprospecting of endophytes is highlighted by following the advantages of the ethnomedicinal approach together with identifying unique medicinal plants where biological activity may be due to endophytes. This review focuses on the current status of South African medicinal plants to motivate the research community to harness the benefits of ethnobotanical knowledge to investigate the presence of endophytic microbes from the most potent South African medicinal plants. The potential chemical diversity and subsequent putative medicinal value of endophytes is deserving of further research. A timely and comprehensive review of literature on recently isolated endophytes and their metabolites was conducted. Worldwide literature from the last 2 years demonstrating the importance of ethnobotanical knowledge as a useful approach to discover endophytic microbes was documented. Information was obtained from scientific databases such as Pubmed, Scopus, Scirus, Google Scholar, Dictionary of Natural Products, Chemical Abstracts Services, official websites, and scientific databases on ethnomedicines. Primary sources such as books, reports, dissertations, and thesises were accessed where available. Recently published information on isolated endophytes with promising bioactivity and their bioactive natural products worldwide (2015-2017) was summarized. The potential value of South African medicinal plants as sources of endophytes is discussed. The insights provided through this study indicate that medicinal plants in South Africa are highly under-investigated sources of potentially useful endophytic microbes. New approaches may be used by medicinal plant scientists for further exploration of natural products from endophytic fungi and bacteria in southern Africa.

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Section: Current Screening Studies For Endophytes and Their Metabolitmentioning

confidence: 99%

Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes

Abdalla

McGaw

2018

Front. Pharmacol.

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“…There are relatively few reports on the endophytic fungi associated with medicinal plants. Among them, Hammerschmidt et al (2015) isolated Xylaria sp. from healthy leaves of plants collected on the island of Timor, Indonesia, and the fungus produced a new compound (resacetophenone).…”

Section: Introductionmentioning

confidence: 99%

Endophytic Fungi from Four Indonesian Medicinal Plants and Their Inhibitory Effect on Plant Pathogenic Fusarium oxysporum

Sukarno

Ginting²,

Widyastuti

et al. 2021

HAYATI J Biosci

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The medicinal plants Centella asiatica, Curcuma xanthorrhiza, Guazuma ulmifolia, and Hydrocotyle verticillata are widely used in Indonesian traditional medicine, but little is known about their associated endophytic fungi. This research aimed to study the diversity of endophytic fungi derived from functional parts of these plants and to evaluate their potential as antifungal agents against the plant pathogenic fungus Fusarium oxysporum. A total of 17 isolates of endophytic fungi were obtained: nine from leaves of G. ulmifolia, three each from leaves of C. asiatica and H. verticillata, and two from rhizomes of C. xanthorrhiza. The genus Colletotrichum was found in all plants studied, but each plant was associated with different species. Colletotrichum aeschynomenes was associated with C. xanthorrhiza, C. siamense was associated with C. asiatica, and C. tropicale was associated with G. ulmifolia and H. verticillata. The species Curvularia affinis, Diaporthe tectonae, Lasiodiplodia mahajangana, Parengyodontium album, Talaromyces trachyspermus, and Speiropsis pedatospora were found only in G. ulmifolia; while Didymella coffeae-arabicae and Muyocopron laterale were found only in H. verticillata. The endophytic fungi showed inhibition activity against F. oxysporum with inhibition values of 6.0-78.9%, T. trachyspermus JBd10 and C. affinis JBd14 gave the highest inhibition activity.

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“…But it is still constrained by the limited raw material in quantity and quality rhizome of temulawak. There are secondary metabolites in curcuma rhizome, [6][7][8] some have antibacterial activities, 9 and allelopathy effects on surrounding plants.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Physiological Characteristics of Curcuma (Curcuma xanthorhizha Roxb.) on Various Intercropping Patterns with Soybean [Gglycine max (L.) Merrill]

Nihayati

Armita

Rulliyah

2017

IJPB

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Purpose of this research was to get the best planting pattern on Curcuma (Curcuma xanthorrhiza Roxb. Synm. Curcuma javanica) and soybean (Glycine max (L.) Merrill) related to plants production, land equivalent ratio (LER) and R/C ratio. This research used the randomized block design involving six treatments and four replications. The growth pattern and yield of curcuma were based on the following parameters: length of plant, number of leaf, broad of leaf, fresh and dry weight of leaves, curcuma root and rhizome, LER (land equivalent ratio) and R/C ratio within six months from December 2015 to June 2016. The treatment difference was based on the LSD5%. The result showed that curcuma planted one month earlier under narrow spacing and bigger soybean population (strip relay, T-K)) suggested a longer growth than any other plating patterns. On the contrary, curcuma planted one month earlier under wide spacing and fewer number of soybean plants (row relay, T-K) suggested a better growth than others and resulting in the highest curcuma yield, lower soybean yield, LER=1.09 dan R/C=2.36.

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Two new metabolites from the endophytic fungus Xylaria sp. isolated from the medicinal plant Curcuma xanthorrhiza

Cited by 23 publications

References 24 publications

Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes

Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes

Endophytic Fungi from Four Indonesian Medicinal Plants and Their Inhibitory Effect on Plant Pathogenic Fusarium oxysporum

Evaluation of Physiological Characteristics of Curcuma (Curcuma xanthorhizha Roxb.) on Various Intercropping Patterns with Soybean [Gglycine max (L.) Merrill]

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