Ultraviolet‐crosslinked hydrogel sustained‐release hydrophobic antibiotics with long‐term antibacterial activity and limited cytotoxicity

Abstract

To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F-127 diacrylate macromer (PF127) was synthesized and then self-assembled into micelles with their hydrophobic cores loaded with EM. The EM-loaded micelles were mixed with a photoinitiator to form the EM/PF127 hydrogels rapidly under a low-intensity UV light. Afterward, the hydrogel properties, antibacterial performance, and cytotoxicity of this novel hybrid hydrogel were investigated. The results show that the EM/PF127 hydrogel had a rapid gelation time. The sustained release of EM reduced its side effects. With controlled antibacterial activity, the use of EM would be safer and more efficient. What is more, the EM/PF127 hydrogel showed a slight cytotoxicity, and this suggests great potential application as antibacterial hydrogels in the prevention of postoperative infection. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40438.

A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

“…Several examples can be found in the literature of combination therapy using micelle systems included in hydrogels [ 26 , 27 , 28 ]. Only a few examples in the literature report on the formation of hydrogels from modified micelles for drug delivery [ 29 , 30 , 31 ]. Undoubtedly, it is a great advantage to have a system formed from a hydrophilic matrix showing drug-accessible hydrophobic clusters that can allocate a wide variety of drugs.…”

“…It represents the characteristic trend of the micelle system plus the effect of partitioning of the hydrophobic drug along the hydrophilic layer composed by the INU portion. In the literature, similar drug delivery systems show similar release behaviors [ 30 , 31 ].…”

Photosensitive antibacterial and cytotoxicity performances of a TiO2/carboxymethyl chitosan/poly(vinyl alcohol) nanocomposite hydrogel by in situ radiation construction

“…Although hydrogels contain a large amount of water, they can display a certain shape as a solid and have very important research and application value as antibacterial dressings . These studies show that hydrogel composite materials have good antibacterial properties against Gram‐positive bacteria (e.g., Staphylococcus aureus ) and Gram‐negative bacteria ( Escherichia coli ) . Furthermore, antimicrobial agents can be combined within hydrogels without impairments in their bioactivity; this may result in advantages of sustainable release of antibacterial …”

Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery

“…The obtained hydrogel possesses high mechanical stability, syringe-injectability, and low erosion rate, and the release of the drug is remotely controlled by NIR irradiation.heat. Recently, Strong et al48 reported the incorpora-Liu et al52 encapsulated erythromycin (EM) in micelles formed by Pluronic F-127 and then obtained an EM/PF127 hydrogel under a low-intensity UV light, in order to extend EM release and prevent side effects of the drug. One of the main drawbacks of some chemotherapeutic agents is their high hydrophobicity which can be related with dangerous side effects.…”