Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract

Taha, Hairin; Arya, Aditya; Paydar, Mohammadjavad; Looi, Chung Yeng; Wong, Won Fen; Murthy, C.R. Vasudeva; Noordin, Mohamed Ibrahim; Ali, Hapipah Mohd; Mohd, Mustafa Ali; Hadi, A. Hamid A.

doi:10.1016/j.fct.2014.01.054

Cited by 35 publications

(24 citation statements)

References 46 publications

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“…The analysis of the results of the studies revealed that most authors reported decreased blood glucose in treated diabetic animals ( n = 33) and normalized plasma insulin levels ( n = 21). Postprandial hyperglycemia is a common pathogenesis of type II diabetes induced by insulin resistance, as well as the partial destruction of pancreas β cells [72–75]. The effective control of blood glucose and insulin level is a key step in preventing or reversing diabetic complications and improving the life quality of patients [76].…”

Section: Discussionmentioning

confidence: 99%

Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

Coelho

Martins

Amaral

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE/PubMed and Scopus databases. Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions.

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Section: Discussionmentioning

confidence: 99%

Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

Coelho

Martins

Amaral

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…The glucose transporter Glut 4 can transport glucose from intra cellular pool to the plasma membrane in muscles and adipose tissues [41]. The glucose uptake can be measured by a fluorescent analogue of D-glucose, 2-[N-(7-Nitrobenz-2-oxa-1,3- diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) [42,43]. Another vital mechanism which assures glucose hemostasis is insulin secretion from pancreatic β-cells [44].…”

Section: Anti-diabetic Activitiesmentioning

confidence: 99%

Pharmacological Properties and Chemical Constituents of Murraya paniculata (L.) Jack

Sayar¹

2014

Medicinal Aromatic Plants

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Chemical Constituents of Murraya paniculata (L.) Jack M. paniculata has been investigated for its bioactive compounds by many research groups. To date, various compounds were identified, ranging from indole alkaloids, coumarins, phenols, terpenoids to flavonoids. Besides, 60 compounds have been identified from volatile and essential oil extracted from M. paniculata leaves. The chemical components from different parts of M. paniculata were identified using chromatographic techniques and the structures were elucidated using spectroscopic techniques. A number of these compounds exhibited significant biological activities, which serve as the scientific evidence for the traditional usage of M. paniculata. In 1986, an anti-implantation alkaloid, called Yuehcukene, 1β-(3,indolyl-7,9α,9β-trimethyl-5β,8,9,10β-tetrahydroindano-[2,3-b] indole was also isolated from M. paniculata leaves [14]. Moreover, the two indole alkaloids, murrayacarine [15] and murrayaculatine [16] were isolated from root bark and flowers of M. paniculata respectively. In early 1980s, different research groups isolated 3' ,4' ,5,5' ,7,8-hexamethoxyflavone (Figure 2a) and 3,3' , 4' ,5,5' ,7,8-heptamethoxyflavone (Figure 2b) from the methanolic extract of M. paniculata leaves [17,18]. Later, a flavone named 3,5,7,3' ,4' ,5'-hexamethoxyflavone, was isolated from M. paniculata flower [16]. Other research groups isolated eight flavonoids from M. paniculata leaves [12,19] and ten flavonoids from the peel and pulp of the fruits of the plant [20].

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“…7 Potent antioxidant properties may be exhibited by flavonoids. 8 Kaempferol, a flavonoid, naturally occurs in a variety of fruits, vegetables, wine, and tea. It can be isolated from tea, broccoli, witch-hazel, propslis, grapefruit, and other plant sources.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats

et al. 2014

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Objective: The aim of the present study was to evaluate the protective effect of kaempferol against oxidative stress in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced in male, adult albino rats of the Wistar strain, by intraperitoneal administration of STZ (40 mg/kg body weight (BW)). Kaempferol (100 mg/kg BW) or glibenclamide (600 μg/kg BW) was administered orally once daily for 45 days to normal and STZ-induced diabetic rats. Results: The STZ-induced diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes in plasma, liver, kidney, and heart whereas they showed significantly decreased level of plasma insulin. The levels of nonenzymic antioxidants (vitamin C, vitamin E, reduced glutathione) in plasma, liver, kidney, and heart and the activities of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase) in liver, kidney, and heart were significantly decreased in diabetic rats. Administration of kaempferol to diabetic rats was showed brought back in plasma glucose, insulin, lipid peroxidation products, enzymatic, and non-enzymatic antioxidants to near normal. Conclusion: The present study indicates that kaempferol has a good antioxidant property, as evidenced by its increase of antioxidant status and decrease of lipid peroxidation markers, thus providing protection from the risks of diabetic complications.

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Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract

Cited by 35 publications

References 46 publications

Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

Pharmacological Properties and Chemical Constituents of Murraya paniculata (L.) Jack

Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats

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