Vegetables, fruits, and legumes: Effect on urinary isoflavonoid phytoestrogen and lignan excretion

Hutchins, Andrea M.; Lampe, Johanna W.; Martini, Margaret C.; Campbell, Deborah R.; Potter, John D.; Slavin, Joanne

doi:10.1016/0002-8223(94)91705-1

Cited by 24 publications

(28 citation statements)

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“…Although the subjects continued consuming their regular diets during the experimental period, which most likely varied in lignan content, the differences in serum enterolactone persisted even after significant addition of dietary precursors. The same was the case in another study in which the range of urinary enterolactone concentration widened further following the vegetable and fruit supplementation (Hutchins et al, 1995). In agreement with these observations our study clearly demonstrates the interindividual differences in serum enterolactone level which do not seem to disappear with supplementation of plant lignans.…”

Section: Discussionsupporting

confidence: 91%

Phloem fortification in rye bread elevates serum enterolactone level

et al. 2002

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Objective: To analyse the lignan content of phloem powder enriched rye bread and to study the dose -response relationship of the effect of dietary plant lignans derived from phloem on intestinal production of enterolactone by measuring enterolactone concentration in serum. Design: A randomized double-blind supplementation trial. Subjects: Seventy-five non-smoking men recruited by newspaper advertisements. Intervention: Subjects were randomized to three study groups receiving either rye bread high in phloem (HP, 14% of rye flour substituted with phloem powder), rye bread low in phloem (LP, 7% of rye flour substituted with phloem powder) or placebo rye bread. Participants consumed 70 g of study bread daily for 4 weeks and provided serum samples for enterolactone analysis at baseline and at the end of the intervention. Results: There was a significant increase in serum enterolactone concentration in the LP and HP groups compared with the placebo group (P ¼ 0.009 and P ¼ 0.003, respectively). Considerable interindividual differences were observed in the response to dietary lignans within the study groups. Conclusions: Our results indicate that plant lignans attached to insoluble fibre layer in phloem can be further metabolized and converted to enterolactone presumably by the bacteria present in the colon. Phloem powder is useful source of lignans for functional foods aimed to elevate serum enterolactone levels. Sponsorship: Phloem powder and the study breads were provided by Finnpettu Oy and Linkosuo Oy, respectively. The clinical study work was sponsored in part by Oy Jurilab Ltd.

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Section: Discussionsupporting

confidence: 91%

Phloem fortification in rye bread elevates serum enterolactone level

et al. 2002

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“…postmenopausal Finnish women who were omnivores and vegetarians (Uehara et al, 2000a,b). Vegetarian women in Boston and Helsinki (Adlercreutz et al, 1986), men and women consuming an experimental cruciferous diet (Kirkman et al, 1995), and Boston women consuming a macrobiotic diet excreted significantly higher urinary levels of these lignans (Hutchins, 1995a). Urinary enterolactone and enterodiol levels have been reported to vary by age, gender, race/ethnicity, and income (Valentin-Blasini et al, 2003).…”

Section: Urinary O-desmethylangolensinmentioning

confidence: 99%

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

Huber

Blount

Mage

et al. 2010

J Expo Sci Environ Epidemiol

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“…Gooderham et al, 1996;Uehar et al, 2000;Arai et al, 2000;L'homme et al, 2002); breast milk (Franke et al, 1999); breast tissue (Maubach et al, 2003); and amniotic fluid Foster et al, 2002); however, urinary measurements are typically the most common. Urinary phytoestrogen levels have been reported in several populations in the United States and abroad (Adlercreutz et al, 1991;Hutchins et al, 1995a;Horn-Ross et al, 1997;Roach et al, 1998;Lampe et al, 1999;Arai et al, 2000;Dai et al, 2002;Valentı´n-Blasini et al, 2003). Men who consumed soy-or tempeh-enhanced diets had isoflavone concentrations about 10-fold higher than those on selfselected diets (Hutchins et al, 1995b).…”

Section: Introductionmentioning

confidence: 99%

Urinary phytoestrogen concentrations in the U.S. population (1999–2000)

Valentín-Blasini

Sadowski

Walden

et al. 2005

J Expo Sci Environ Epidemiol

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We report population-based urinary concentrations of phytoestrogens stratified by age, sex, and composite racial/ethnic variables. We measured the isoflavones F genistein, daidzein, equol, and O-desmethylangolensin (O-DMA) F and the lignans F enterolactone and enterodiol F in approximately 2500 urine samples from individuals aged 6 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) in 1999 and 2000. We detected all phytoestrogens in over 70% of the samples analyzed; enterolactone was detected in the highest concentrations, and daidzein was detected with the highest frequency. The geometric means for each phytoestrogen were as follows: genistein, 22.3 mg/g; daidzein, 68.6 mg/g; equol, 7.65 mg/g; O-DMA, 3.95 mg/g; enterolactone, 217 mg/g; and enterodiol, 24.3 mg/g creatinine. The 95th percentiles for each phytoestrogen were as follows: genistein, 380 mg/g; daidzein, 944 mg/g; equol, 50.3 mg/g; O-DMA, 217 mg/g; enterolactone, 2240 mg/g; and enterodiol, 240 mg/g creatinine. Multivariate analyses showed statistically significant differences among many of the demographic subgroups. Adolescents had higher concentrations of genistein and equol than adults. Non-Hispanic whites had higher concentrations of enterodiol and equol than Mexican Americans or non-Hispanic blacks. Non-Hispanic whites also had higher concentrations of enterolactone and O-DMA than Mexican Americans. Mexican Americans had higher concentrations of genistein than non-Hispanic blacks; however, the opposite was found for O-DMA. Determination of phytoestrogen exposure in the US population will help us to better understand phytoestrogen consumption in the US and will assist us in elucidating the potential role of phytoestrogens in protecting against cancer and heart disease.

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Vegetables, fruits, and legumes: Effect on urinary isoflavonoid phytoestrogen and lignan excretion

Cited by 24 publications

References 0 publications

Phloem fortification in rye bread elevates serum enterolactone level

Phloem fortification in rye bread elevates serum enterolactone level

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

Urinary phytoestrogen concentrations in the U.S. population (1999–2000)

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