Vitamin D for Menstrual and Pain-Related Disorders in Women

Bertone‐Johnson, Elizabeth R.

doi:10.1001/archinte.172.4.367

Cited by 11 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, 1,25(OH) 2 D down-regulates prostaglandin receptor expression. 1,25(OH) 2 D may also exert anti-inflammatory effects through other pathways [ 16 ]. The liver converts all available cholecalciferol into 25(OH)D. The major source of vitamin D in the body is this metabolite, which has a half-life of at least three months [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the endometrium, 1,25-dihydroxyvitamin D (1,25[OH] 2 D), the bioactive form of vitamin D, decreases prostaglandin synthesis by suppressing expression of cyclooxygenase-2, and increases prostaglandin inactivation by up-regulating 15-hydroxyprostaglandin dehydrogenase. In addition, [16]. The liver converts all available cholecalciferol into 25(OH)D. The major source of vitamin D in the body is this metabolite, which has a half-life of at least three months [26].…”

Section: Discussionmentioning

confidence: 99%

“…The active form of vitamin D can reduce prostaglandin production in the endometrium and limit its biological activity by affecting prostaglandin receptors [ 15 ]. It may also exert anti-inflammatory effects through various pathways [ 16 ]. It remains unclear whether vitamin D is therapeutic for reducing menstrual flow.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

et al. 2023

View full text Add to dashboard Cite

Background Primary dysmenorrhea is considered as one of the women’s main problems during reproductive age. The present study aimed to investigate the effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss. Methods This double-blind, randomized, placebo-controlled trial, was performed on 84 single female college students between 18 and 25 years old who living in dormitories. Students with primary dysmenorrhea and vitamin D deficiency were divided into experimental (n = 42) and control (n = 42) groups. Five days before the putative beginning of their next menstrual cycle, the experimental group received 300,000 IU vitamin D (50,000 IU, two tablets every 8 h), and the control group received a placebo (oral paraffin). The effects of the supplement on the severity of dysmenorrhea and menstrual blood loss were evaluated one cycle before and during two successive cycles. Using the visual analog scale (VAS), verbal multidimensional scoring system (VMS), and pictorial blood assessment chart (PBLAC) questionnaires. Fisher’s exact, Chi-square, independent sample t-test and repeated measurements were used. Results In total, 78 of the 84 students completed the study (39 students per group). The intervention resulted in a significant reduction in the mean scores of both the VAS and VMS in the experimental group, in the first and second menstrual cycles (p < 0.001, p < 0.001, respectively), but not in the means score of PBLAC. Mefenamic acid consumption at the first and second menstruation period, in the experimental group was lower than the control group (p = 0.009, p < 0.001, respectively). Conclusions The results indicate that vitamin D supplementation could decrease the severity of primary dysmenorrhea and the need to consume pain-relief medications. Contrariwise vitamin D supplementation had no significant effect on menstrual blood loss. Trial registration This trial was registered in the Iranian Registry of Clinical Trials with code IRCT201305212324N on 18/1/2014. URL of registry: https://en.irct.ir/trial/1964.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Several studies have investigated the effects of vitamins D and E and ginger on primary dysmenorrhea [2478911121415171819202122232425262728]. However, this study is the first clinical trial that aimed to compare their cumulative effects on the severity of dysmenorrhea.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial

et al. 2019

View full text Add to dashboard Cite

ObjectiveDysmenorrhea is one of the most common problems for women, especially during their reproductive age. Various studies have examined the effects of vitamins D and E and ginger supplements. This study aimed to investigate the individual effects of each of these supplements on dysmenorrhea.MethodsThis single-blind clinical trial was conducted in 2016 on students aged 18 to 25 years who complained of mild to severe dysmenorrhea. The participants were randomly assigned into 4 groups: vitamin D, vitamin E, ginger, and placebo. The effects of the supplements on the severity of dysmenorrhea were evaluated in 2 successive cycles using the visual analog scale (VAS) and a questionnaire.ResultsInitially, 240 female students were enrolled in the study; thereafter, 40 students were excluded from the study owing to follow-up loss. The average VAS score for dysmenorrhea in the entire study population was 7.13±0.80 before the intervention; the mean VAS score after the first and second months of supplement use was 5.37±1.51 and 4.93±1.48, respectively. The highest reduction in pain severity was observed in the ginger group (F=74.54, P<0.001).ConclusionVitamin D, vitamin E, and ginger significantly reduced the severity of dysmenorrhea, with ginger having the most significant effect followed by vitamin D and vitamin E. Given the low risk of these supplements, more studies must be conducted on their use as opposed to analgesics.

show abstract

Nutritional practices to manage menstrual cycle related symptoms: a systematic review

Brown,

Martin,

Waldron

et al. 2023

Nutr. Res. Rev.

View full text Add to dashboard Cite

Certain nutritional practices may reduce menstrual-related symptoms, but there is no current consensus on what foods/supplements are sufficiently evidenced to warrant promotion to reduce menstrual symptoms of naturally menstruating individuals. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two online databases were searched for published experimental studies that investigated the effects of foods/supplements on menstrual-related symptoms in eumenorrheic women. Extracted data and study characteristics were tabulated and grouped based on food/supplement intervention and dosage compared to UK dietary reference values (DRVs) and safe upper limits. In total, 28 studies and 21 different foods/supplement interventions were included in the review. None of the studies reported a negative effect on symptoms, 23 reported a positive effect and 5 had no effect. Eighteen different ways of measuring menstrual-related symptoms were described across the studies. The results indicate a lack of consistency in studies to confidently provide information to eumenorrheic, naturally menstruating women regarding the use of foods/supplements to reduce menstrual symptoms. Determination of menstrual-related symptoms varied along with dose and duration of food or supplements provided. These data provide some evidence for the use of vitamin D, calcium, zinc and curcumin to reduce menstrual related symptoms of non-hormonal contraceptive users, on an individual basis, however further investigation is required prior to implementation with a focus on robust protocols to determine and measure changes in menstrual symptoms, with interventions adhering to DRVs and safe upper limits.

show abstract

Vitamin D for Menstrual and Pain-Related Disorders in Women

Cited by 11 publications

References 9 publications

The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial

Nutritional practices to manage menstrual cycle related symptoms: a systematic review

Contact Info

Product

Resources

About