Wildebeest-associated malignant catarrhal fever in Africa: A neoplastic disease of cattle caused by an oncogenic herpesvirus?

Hunt, Ronald D.; Billups, Leonard H.

doi:10.1016/0147-9571(79)90015-8

Cited by 17 publications

(9 citation statements)

References 9 publications

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“…Other important pathogenic herpesviruses belonging to this subfamily include Epstein-Barr virus, H. saimiri, H. ateles, H. sylvilagus, and Marek's disease virus. The unique pathogenesis of MCF involves the proliferation of T lymphocytes [5]. Since available serological methods have not been able to detect the virus and its viral antigens in proliferating lymphocytes and tissue sites of lesion formation [2,8,9,15], phenomena such as the autoimmune response and lymphocyte transformation were proposed in the pathogenesis of MCF [1,3,[5][6][7]19].…”

mentioning

confidence: 99%

A diagnostic method to detect alcelaphine herpesvirus-1 of malignant catarrhal fever using the polymerase chain reaction

Hsu

Shih

Castro

et al. 1990

Archives of Virology

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A sensitive diagnostic method specific for alcelaphine herpesvirus-1, causative agent of malignant catarrhal fever, has been developed. Based on the nucleotide sequence of the alcelaphine herpesvirus-1 genomic DNA, a pair of 30 nucleotide primers was selected and synthesized for detecting the virus genome using the polymerase chain reaction (PCR). The virus genome was detected in crude cell lysate using the amplification reaction.

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mentioning

confidence: 99%

A diagnostic method to detect alcelaphine herpesvirus-1 of malignant catarrhal fever using the polymerase chain reaction

Hsu

Shih

Castro

et al. 1990

Archives of Virology

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“…The sheep-associated virus has not been successfully isolated, but it is reported to be immunologically related to MCFV [4,13,16,17]. The same techniques also can be used to detect if the virus DNA is integrated into the host chromosome as suggested by Hunt and Billup [5].…”

Section: Discussionmentioning

confidence: 93%

“…The disease is sporadic but frequently fatal [3,5,[10][11][12]. MCFV is classified in the subfamily Gammaherpesvirinae along with Epstein-Barr virus, saimiri, ateles, sylvilagus, and Marek's disease virus [14], and little is known of its genetic compositions.…”

Section: Introductionmentioning

confidence: 99%

Nucleotide sequence of a 3.5 kilobase fragment of malignant catarrhal fever virus strain WC11

Hsu

Shih

Zee

1990

Archives of Virology

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A 3.5 kilobase DNA fragment of the malignant catarrhal fever virus (MCFV), strain WC11, was mapped with a number of restriction enzymes, subcloned and sequenced. The fragment was subcloned into plasmid vector, pUC19, for direct sequencing. A complete open reading frame of 2,058 base pairs and a partial open reading frame of 630 base pairs were identified. The sequence of 3,389 nucleotides was compared to other herpesviruses. A 310 base pairs sequence in gene A was 57% homologous to a sequence in reading frame BXLF1 of Epstein-Barr virus strain B95-8.

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“…It has been suggested that dysfunction of this cell type following infection is responsible for the pathological changes observed in MCF . Numerous authors have commented upon the similarity of the pathology of AHV-I to that of the T-lymphotropic gammaherpesviruses (Hunt & Billups, 1979;Patel & Edington, 1980, 1981Plowright, 1982). The major difference lies in the essentially neoplastic response of animals reacting with HVS or HVA, as compared with the response in MCFaffected animals which is both lymphoproliferative and degenerative.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Characterization of the Alcelaphine Herpesvirus 1 Genome

Bridgen

Herring²,

Inglis³

et al. 1989

Journal of General Virology

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SUMMARYAlcelaphine herpesvirus type 1 (AHV-1) is a causative agent of the fatal lymphoproliferative disease malignant catarrhal fever in deer and cattle. The genomes of the attenuated WCI 1 isolate and the virulent C500 isolate have been studied. The genome of WC 11 comprises a region of unique DNA of approximately 130 kbp, which has a G + C content of 509/o, and approximately 30 kbp of additional tandem direct repeat sequences with a G+C content of 72~o. WCll possesses a major repeat sequence of 950 bp interspersed with a small number of related sequences of different length; these sequences are probably terminal in location. DNA from the C500 isolate has a similar restriction profile to that of WCll in the unique region, but only one repeat sequence of 1050 bp is present. We propose, on the basis of biological and stnactural properties, that AHV-1 be included within the 72 group of herpesviruses of which herpesvirus ateles is the prototype.

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Wildebeest-associated malignant catarrhal fever in Africa: A neoplastic disease of cattle caused by an oncogenic herpesvirus?

Cited by 17 publications

References 9 publications

A diagnostic method to detect alcelaphine herpesvirus-1 of malignant catarrhal fever using the polymerase chain reaction

A diagnostic method to detect alcelaphine herpesvirus-1 of malignant catarrhal fever using the polymerase chain reaction

Nucleotide sequence of a 3.5 kilobase fragment of malignant catarrhal fever virus strain WC11

Preliminary Characterization of the Alcelaphine Herpesvirus 1 Genome

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