Zur Frage der Existenz von «γ‐Sitosterol» Nachweis von Cholesterol als Bestandteil des «γ‐Sitosterols» einer <i>Digitalis</i>‐Art

Linde, Horst H. A.; Ergenç, N.; Meyer, Kuno

doi:10.1002/hlca.19660490405

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…As one of the exceptions among the dicots, Digitalis contains steroidal saponins that are derived from C 27 sterols. They bear a cholesterol scaffold, and indeed this "animal sterol" was detected in Digitalis species [6,105] and was discussed as a sterol precursor of cardenolides (see below: Biosynthesis). The Digitalis saponins identified so far comprise neutral monodesmosides (spirostanol type) or bisdesmosides (furostanol-type) possessing only a weak saponin character.…”

Section: Sterols and Steroid Saponinsmentioning

confidence: 99%

The Foxgloves (Digitalis) Revisited

Kreis

2017

Planta Med

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This review provides a renewed look at the genus Digitalis. Emphasis will be put on those issues that attracted the most attention or even went through paradigmatic changes since the turn of the millennium. PubMed and Google Scholar were used (“Digitalis” and “Foxglove” were the key words) to identify research from 2000 till 2017 containing data relevant enough to be presented here. Intriguing new results emerged from studies related to the phylogeny and taxonomy of the genus as well as to the biosynthesis and potential medicinal uses of the key active compounds, the cardiac glycosides. Several Eastern and Western Foxgloves were studied with respect to their propagation in vitro. In this context, molecular biology tools were applied and phytochemical analyses were conducted. Structure elucidation and analytical methods, which have experienced less exciting progress, will not be considered here in great detail.

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Section: Sterols and Steroid Saponinsmentioning

confidence: 99%

The Foxgloves (Digitalis) Revisited

Kreis

2017

Planta Med

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Die Zusammensetzung handelsüblicher β‐Sitosterin‐Präparate

Auterhoff

Nickoleit

1972

Archiv der Pharmazie

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Es wurden handelsiibliche PSitosterin-Praparate gaschromatographisch untersucht und dabei gefunden, dal3 sie stets aus zwei Substanzen bestanden. Der Begleiter des wahren PSitosterins wurde als Campesterin identifiziert. Die Zusammensetzung der Handelspraparate schwankte zwischen 58 bis 63 % PSitosterin und 42 bis 37 % Campesterin. The Composition of Commercial Hitosterol RoductsCommercial Psitosterol products have been studied by gas-chromatography, and it was found that they consisted always of 2 substances. The accompanying substance of the real P-sitosterol was identified as campesterol. The composition of the commercial products fluctuated between 58-63 % Psitosterol and 42--37 % campesterol. GaschromatographieHewlett-Packard/Moseley Gaschromatograph, Typ 5 754 C , Flammenionisationsdetektor. Kolonne: 1,8 m lange Glassaule, hnendurchmesser 2 mm, gefiillt mit 1 % SE-30 + 1 % QF-1 auf HP Chromosorb WAW DMCS 80/100 mesh, Stickstoff a k Triigergas. EinlaStemperatur: 270°, Saulentemperatur 240 bzw. 260". 9 C. H. Brieskorn und H. Herrig, Arch. Pharmaz. 292, 485 (1959).Arch. Pharmaz. 0-Sitosterin-hiparate107 Zusammensetzung der verschiedenen ,, pfltosterin " -R a p a t e RaparatBSitosterin Qmpesterin ,,pSitosterin" Aldrich Chem. Co.,

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Die Cardenolide und Pregnan‐Glykoside der Wurzeln von Asclepias lilacina WEIMARCK. I. Isolierungen Glykoside und Aglykone, 290. Mitteilung

Sawlewicz¹,

Weiss²,

Reichstein³

1967

Helvetica Chimica Acta

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The dried roots of Asclepias lilacina contain ca. 14% glykosides, in which both cardenolides and ester glycosides of pregnane derivatives are present, the latter predominating. Uzarigenin, coroglaucigenin, and their corresponding glycosides ascleposide and frugoside, resp., were shown to be present; of these four, uzarigenin was isolated in crystalline form. The ester glycosides, some of which could be isolated in a crystalline state, are predominantly composed of the aglycones 20‐O‐acetyl‐12‐O‐benzoyl‐sarcostin and 12,20‐di‐O‐benzoyl‐sarcostin, besides which esters of desacetyl‐metaplexigenin, lineolon, and dihydrosarcostin are also present. These aglycones are mostly attached to various trisaccharides which are composed of at least two 2‐deoxy‐sugar residues. Mild acid hydrolysis gave, besides the genins, 7 sugars, namely cymarose, oleandrose, digitoxose, 3‐O‐methyl‐6‐deoxy‐D‐allose (U3), as well as 3 unknown sugars U1, U2 and U5 which are probably disaccharides. U1 and U2 were isolated in crystalline form; they are isomeric and have been named asclepobiose and lilacinobiose; they are probably composed of units similar to those in the isomeric pachybiose.

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Zur Frage der Existenz von «γ‐Sitosterol» Nachweis von Cholesterol als Bestandteil des «γ‐Sitosterols» einer Digitalis‐Art

Cited by 9 publications

References 20 publications

The Foxgloves (Digitalis) Revisited

The Foxgloves (Digitalis) Revisited

Die Zusammensetzung handelsüblicher β‐Sitosterin‐Präparate

Die Cardenolide und Pregnan‐Glykoside der Wurzeln von Asclepias lilacina WEIMARCK. I. Isolierungen Glykoside und Aglykone, 290. Mitteilung

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