In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.

The semi-synthesis of 11 isatin derivatives was achieved through bimolecular nucleophilic substitution and click chemistry. Seven new compounds were obtained. All chemical structures were determined by infrared spectroscopy (IR), nuclear magnetic resonance spectrometry (NMR) and high-resolution mass spectrometry (HRMS) data. These derivatives were evaluated for their anti-GSK-3β activity and all isatin derivatives (N-alkyl and 1,2,3-triazolic) exhibited strong inhibitory activity, with 2b and 4h exhibiting remarkable potency. In addition, docking studies were performed with 2b and 2e models to unravel the molecular mechanism underlying the polar interactions on the GSK-3β ATP-binding site. Scheme 1. (i) Potassium carbonate, dimethylformamide or acetone; (ii) commercial bromide, r.t.

One of the priorities to address food security is to increase the access of farmers to biotechnology, through the application of scientific advances, such as genetically modified organisms and food (GMF). However, the spread of (mis)information about their safety strengthens the clamor for mandatory GMF labeling. This paper provides an overview of food labeling policies, considering the principles suggested by the Codex Alimentarius Commission, and analyzes the consequences for the world food security of the Brazilian labeling policies compared to developed countries. We discuss the discriminatory application of GMF mandatory labeling in the absence of any scientific evidence as it has the potential of causing social harm and jeopardizes research, production, and distribution of food and consumers' right to information.

This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), and scanning electronic microscopy (SEM) can be useful tools for evaluating the quality of active pharmaceutical ingredients (APIs) and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simultaneous determination of lidocaine (LID), ciprofloxacin (CFX) and enrofloxacin (EFX) in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini C18 (250 mm × 4.6 mm, 5 µm) Phenomenex® column, at a temperature of 25 °C, with a mobile phase containing 10 mM of phosphoric acid (pH 3.29): acetonitrile (85.7:14.3, v/v) and a flow rate of 1.5 mL/min. Physicochemical characterization by TG, FTIR, and SEM of raw materials of LID, CFX, and EFX provided information useful for the evaluation, differentiation, and qualification of raw materials. Finally, the HPLC method was proved to be useful for evaluation of raw material and finished products, besides satisfying the need for an analytical method that allows simultaneous determination of EFX, CFX, and LID, which can also be extended to other matrices and applications.

Objetivo. Descrever a percepção de mulheres venezuelanas sobre o acesso aos serviços de saúde, ao diagnóstico e ao tratamento de HIV/aids e sífilis no Brasil. Métodos. Trata-se de um estudo descritivo e exploratório, com abordagem qualitativa, realizado no período de fevereiro a maio de 2021 nos municípios de Manaus, estado do Amazonas, e Boa Vista, estado de Roraima. As entrevistas com as participantes foram transcritas na íntegra, com levantamento de temas a partir de análise de conteúdo. Resultados. Foram entrevistadas 40 mulheres (20 em Manaus e 20 em Boa Vista). A partir da transcrição e tradução das falas, foram identificadas duas categorias de análise de conteúdo: barreiras de acesso aos serviços de saúde, com quatro subcategorias — idioma, custos com saúde, reações adversas ao medicamento e pandemia de covid-19; e facilitadores do acesso, com quatro subcategorias — Sistema Único de Saúde, Política Nacional de Atenção Integral à Saúde da Mulher, Política Nacional de Assistência Social e relação entre profissional de saúde e usuária do Sistema Único de Saúde. Conclusão. Os resultados mostraram a necessidade de elaborar estratégias para mitigar as dificuldades enfrentadas pelas mulheres migrantes da Venezuela residentes no Brasil quanto ao diagnóstico e tratamento de HIV/aids e sífilis, indo além do amparo à saúde garantido pela lei.