MB-PDT is a cheap and efficient method of decreasing MM volume and thus disease progression. This reduction is mediated by downregulation of PCNA and heparanases.
Resumo: O carcinoma verrucoso é uma rara e indolente forma do carcinoma espinocelular descrita por Ackerman em 1948. Sua localização preferencial é a cavidade oral. Clinicamente manifesta-se como lesão verrucosa, de progressivo e lento crescimento e bom prognóstico. O tratamento de escolha é a exérese cirúrgica, devendo o paciente ser regularmente acompanhado devido ao risco de recorrências. Palavras-chave: carcinoma de células escamosas; carcinoma de células escamosas/diagnóstico; carcinoma de células escamosas/patologia. Abstract Comunicação / Communication COMMENT Squamous cell carcinoma (S C C) stems from kera t i n o c y t e s . 1 S C C p resents as several clinical and histopathologic variants, including verrucous carcinoma (V C) . Although malignant, this variant does present with characteristics of a benign tumor. 2 The "benign" characteristics of V C a re slow growth, a pro g ression pattern that is more expansive than invasive, and good cellular differe n t i a t i o n . 2 , 3 The expression verrucous carcinoma was defined by L . V. A c k e r m a n 4 in 1948 to characterize a well-differe n t i a t e d v e rrucous neoplasia, with slow growth and without a tendency to metastasize. 5 V C is a S C C with a low degree of dysplasia, and low incidence. 6 Its biological aggressiveness is COMENTÁRIOO carcinoma espinocelular (CEC) surge a partir dos q u e r a t i n ó c i t o s 1 e apresenta diversas variantes clínico-histopatológicas, incluindo o carcinoma verrucoso (CV). Apesar de maligna, essa variante cursa com algumas características de tumor benigno. 2 As características "benignas" do CV são o lento crescimento, o padrão evolutivo mais expansivo do que invasivo, e a boa diferenciação celular. 2,3 A expressão carcinoma verrucoso foi definida por L.V. Ackerman 4 em 1948, para caracterizar uma neoplasia verrucosa, bem diferenciada, de lento crescimento e sem tendência a metastatizar. 5 O CV é um CEC com baixo grau de displasia, de incidência infreqüente. 6 A agressividade
O enxerto cutâneo é um modo efetivo para restaurar feridas. O curativo compressivo é importante para a vitalidade do enxerto. Os autores observaram que o uso de esponja cirúrgica como curativo compressivo em enxertos cutâneos é factível e aconselhável.
Background Psoriasis is a chronic inflammatory disease dependent upon a complex interaction between genetic predisposition and immunological factors. It is characterized by skin lesions throughout the body, causing great morbidity and affecting life quality. The present study aimed to evaluate the protein and mRNA expression of heparanase-1 (HPSE), heparanase-2 (HPSE2), syndecan-1 (SYND1), metalloproteinases (MMP2, MMP9), and tissue inhibitor metalloproteinases 2 (TIMP2) in skin samples. Methods From each psoriasis patient, two samples were collected, one sample from a psoriasis plaque (n = 23) and the other sample from non-affected skin (n = 23), as well as tissue collected by blepharoplasty from control individuals (n = 18). Protein expression was investigated by immunohistochemistry, followed by digital quantification. Quantitative RT-PCR obtained mRNA expression. Statistical analyses were done, and p values < 0.05 were considered significant. Results A significant increase in protein and mRNA expression was observed in both heparanases (HPSE and HPSE2), and higher protein levels of MMP9 and TIMP2 were observed in the psoriasis plaque compared to the non-affected skin. The data point to a probable activation of MMP2 by TIMP2. Moreover, there was a significant increase in HPSE2, SYND1, MMP9, and TIMP2 in non-affected skin samples from patients with psoriasis than in the control sample (tissue obtained by individuals who do not have psoriasis). Conclusions These results show a possible correlation between the characteristic inflammatory process and alterations in the expression of the extracellular matrix in psoriasis. The increased expression of HPSE2, SYND1, MMP9, and TIMP2, even in the absence of psoriatic plaque, indicates that these molecules may be involved with extracellular matrix changes in the initial alterations the psoriatic process and may be candidates for the development of target treatments.
Vitiligo is a dermatosis requiring complex treatment. In clinically stable cases, melanocyte autologous grafting has shown good results, using different methodologies for obtaining the donor area: dermatomes, punches, blisters. However, these techniques are complex and require specific instruments. This study presents a simple technique for melanocyte harvest that has been performed in our service for more than ten years and includes epidermal curettage of the donor area, grafting of the obtained material, which was homogenized with saline or hyaluronic acid, on the achromic area, and the application of a semipermeable dressing that is removed 1 week later.
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