BACKGROUND: WHO declared the coronavirus disease (COVID)-19 outbreaks as a worldwide pandemic in March 2020. More than 1,500,000 confirmed cases have been diagnosed in more than 130 countries and regions, estimated to cause 93,000 deaths so far recorded on April 10, 2020. There is no vaccine or antiviral treatment for coronavirus. METHODS: The literature sources from the research were obtained by searching for national and international journals. The journal is indexed in Google Scholar, PubMed, Science Direct, e-books, and others. Five journals were obtained, including a literature review, systematic review, and randomized controlled trials (RCT) discussing the use of dexamethasone in COVID-19 therapy, Middle East respiratory syndrome, and severe acute respiratory syndrome. RESULTS: A study from Oxford University compared 2100 COVID-19 patients who received low and moderate potential dexamethasone at a dose of 6 mg/day for 10 days with 4300 COVID-19 patients who only received standard treatment for coronavirus infection. The results obtained in patients using ventilator mortality decreased from 40% to 28%, and patients using oxygen, the mortality rate decreased from 40% to 20%. The dexamethasone RCT study can reduce the death rate of 1 in 3 COVID-19 patients who received mechanical ventilation therapy and 1 in 5 patients who received oxygen therapy without mechanical ventilation but did not reduce patients’ mortality rate who did not receive therapy oxygen. CONCLUSION: The use of dexamethasone with oxygen therapy and mechanical ventilation can reduce mortality patients with COVID-19.

Latar belakang :Penggunaan obat secara tradisional semakin disukai karena pada umumnya tidakmenimbulkan efek samping seperti halnya obat-obatan dari bahan kimia, dan terdapat banyak tanaman obat yang ada di Indonesia yang belum dimanfaatkan, misalnyaMentimun (Cucumis sativus L.)adalah salah satu tanaman yang berkhasiat sebagai antipiretik, kecantikan, memperlancar buang air kecil, mengobati pasien hipertensi, sariawan, tifus dan diare. Mentimun belum diteliti secara klinis. Tujuan :Mengetahui efek antipiretik jus buah mentimun ( cucumis sativus L.) pada mencit yang diinduksi demam dengan penyuntikan vaksin DPT-Hb Material dan metode : 55 ekor mencit diinduksi demam dengan menyuntikkan 0,3 mL vaksin DPT-Hb 240 menit sebelum percobaan dan diukur suhunya setiap 15 menit selama 120 menit.Secara random binatang percobaan dibagi 5 kelompok, tiap kelompok terdiri dari 11 mencit (kelompok kontrol - demam tanpa perlakuan), aquadest (demam + air) dan 3 kelompok perlakuan dengan jus buah mentimun (Cucumis Sativus L.) dosis bertingkat yaitu 0.25 ml, 0.5 ml, dan 1 ml.Selama periode tersebut dilakukan pengukuran suhu per rektal secara berkala. Hasil: Diperoleh nilai signifikansi antara kelompok kontrol dan aquadest lebih besar dari 0,05 (p>0.05) yang berarti aquadest tidak memiliki efek antipiretik. Sedangkan nilai signifikansi antara kelompok kontrol dengan pemberian jus buah mentimun dalam tiga dosis lebih kecil dari 0,05        (p < 0,05 ) yang berarti jus mentimun memiliki efek antipiretik. Kesimpulan: jus buah mentimun memiliki efek antipiretik pada mencit yang diinduksi demam dengan penyuntikan vaksin DPT-Hb. Kata kunci : antipiretik, vaksin DPT Hb, mencit, demam, jus buah mentimun    ( cucumis sativus L.)

Chronic Rhinitis is an inflammatory disease of the nose characterized by sneezing, snotty and nasal congestion, intermittently or persistently. The prevalence of rhinitis in the United Kingdom reaches 29%, in Indonesia is not known clearly. The types of work that cause rhinitis are chronic like farmers, laboratory workers, carpenters or painters, food industry workers and, health workers. Chronic Rhinitis can affect the quality of the worker’s life, and it can reduce work productivity Objective: To determine the risk factors for chronic rhinitis on the workers in wood furniture which was contacted by sawdust in the West Palu area Method: This study uses analytical research methods with a cross-sectional approach. The sampling technique is total sampling, and the total sample in this study is 27 workers. Results: The study showed a significant relationship with the incidence of rhinitis to the carpenters who work on wooden furniture in the western Palu on age (p = 0.027), duration of exposure (p = 0.041. There was no significant relationship between the use of PPE (p = 0.100) Conclusion: The factors that can influence the incidence of chronic rhinitis to furniture workers are age and duration of exposure

Latarbelakang :Kistaodontogenic adalah kista dengan struktur epitel berasal dari struktur gigi.Kistaodontogenic sering terjadi didaerah rahang,terutama diregiomaksillaanterior.Tujuan :Untuk memberikan informasi penegakkan diagnosiskista odontogenik terutama di regio maksilla anterior yang sering memberikan gambaran tumor jinak.Laporan kasus :Serial kasus kista odontogenicdiregiomaksilla anterior pada 2 pasien dewasa dengan tatalaksana berupa tindakan ekstirpasi dengan cara enukleasi menggunakan pendekatan midfacialdegloving dan Denkerrhinotomy.Kesimpulan :Kasus yang dilaporkan menunjukkan bahwa kista odontogenik regio maksilla anteriorsering tidak terdiagnosis karena penampakannya menyerupai massa jinak.  Kata kunci :Kistaodontogenik,  maksilla, diagnosis, enukleasi