Amino acids are the basic structural units of protein molecules in the body. Currently, about 300 amino acids are known, of which 26 are studied best. Amino acids or their derivatives (for example, immune bodies) are part of enzymes, hormones, pigments, and other specific substances that play a crucial role in digestive and metabolic processes. In the process of metabolism, many amino acids are synthesized in the body from other amino acids or compounds, and therefore they are called interchangeable. Amino acids that are not synthesized in the body or are formed in insufficient quantities are called indispensable. According to the content and ratio of essential amino acids, feed proteins are subdivided into full and inferior. Deficiency, absence, or imbalance of essential amino acids in animal diets is accompanied by a deterioration in protein use, metabolic disorders, and decreased productivity. The following amino acids are indispensable; arginine, viburnum, histidine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, phenylalanine. Among the essential amino acids, especially important ones, are those called critical. These are lysine, methionine + cystia, threonine, and tryptophan. A deficiency, absence, or imbalance of essential amino acids in animal diets is accompanied by a deterioration in protein use, metabolic disorders, and decreased productivity. Research and production experiment was conducted within Olenka Poultry Factory LLC and the problematic research laboratory of feed additives of the Department of Animal Feeding and Feed Technology named after P. D. Pshenichny at the National University of Life and Environmental Sciences. The effective level of arginine in compound feed for broilers of the Cobb-500 cross was experimentally determined. The use of compound feed with arginine levels in the first rearing period (1 to 10 days) - 1.28%, in the second (11 to 22 days) - 1.15% and in the third (23 to 42 days) - 1.11% gives the opportunity to get broiler chickens at the age of 42 days, weighing 2.654 kg, at a feed expenditure of 1.78 kg per 1 kg of gain.

One of the methods for investigating complex mechanisms of pathological process development in the body is biological modeling. Absence of standardized reproducible experimental models makes comparative assessment of multiple drug efficacy studies including in case of liver diseases much more difficult. Among experimental toxic lesions of the liver, the model of liver lesion induced by tetrachloromethane in mice is widely spread, which has considerable drawbacks. So, for certain tasks it becomes necessary to work with other animal species, in particular, with rabbits. Modeling of acute and chronic lesion of liver was done by intraperitoneal administration of 50 % carbon tetrachloride olive oil solution based on 1 ml per kg of body mass twice a week. In the course of experiment, on day 5 rabbits develop toxic lesion of liver supported by hematology examination. Hepatic functional insufficiency was characterized by hypoproteinemia, dislipidemia, statistically significant increase of serum transaminase activity, total bilirubin. Ultrasound, x-ray, morphological analysis of liver tissues in experimental rabbits showed changes consistent with hepatitis signs. Thus, this investigation has demonstrated that use of rabbits as a model gives a number of advantages: the possibility of studying biochemical markers in dynamics, ultrasound and x-ray monitoring of lesion.

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