Sample preparationThe bioactive components found in purslane are apigenin, isorhamnetin, and luteolin. Meanwhile, star anise has shikimic acid, illicinole, and illicinone A. Data were provided by PubChem. Furthermore, non-structural target protein databases TMPRSS2 and PLpro were obtained from RSCB PDB.

Abstract

At this time, leadership and social media are two things that cannot be separated. Social media becomes an information technology media for leaders to be able to communicate about their vision and purpose. Therefore, leaders must be able to use social media effectively in order to influence the community with what they think. There are three problems caused by leaders in social media which are classified into three types such as narcissistic, compulsive and paranoid. These three things become big problems in leadership on social media and therefore, we need the formula to solve the problems. The Johari Window method is a method that has four perspectives in developing four leadership classifications such as open leaders, blind leaders, hidden leadership, and unknown leaders. If these three types and four classifications are put together, a framework will be produced called "Leadership Intelligence (CI2) Framework", the next one will produce a formula S = W.L2, where this formula will produce wise leaders on social media. This journal is the development of the journal Developing "Framework Intelligence (CI3)" Inside Social Media Using Johari Window Methods and The Development and Implementation of Wise Netizen (E-Comment) In Indonesia. As a result, this journal will give an answer and solve the problem of an ethical leader on social media and how to decrease a hoax that can affect the leader on social media. This research will continue until it produces a CI1 formula that will combine culture and leadership into a social media formula in generating positive communication, creating a positive culture and making a big impact on society.

No abstract

Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy's side effects. Fucoidan is an anticancer bioactive compound derived from Sargassum sp. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from Sargassum sp. against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and in silico study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from Sargassum sp. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.